betaine has been researched along with Choline Deficiency in 27 studies
glycine betaine : The amino acid betaine derived from glycine.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the effects of betaine, an endogenous and dietary methyl donor essential for the methionine-homocysteine cycle, on oxidative stress, inflammation, apoptosis, and autophagy in methionine-choline deficient diet (MCD)-induced non-alcoholic fatty liver disease (NAFLD)." | 7.91 | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. ( Borozan, S; Dragutinovic, V; Gopcevic, K; Isakovic, A; Jorgacevic, B; Labudovic-Borovic, M; Milenkovic, M; Mladenovic, D; Radosavljevic, T; Tosic, J; Trajkovic, V; Veskovic, M; Vucevic, D, 2019) |
| "The results indicated that betaine or beet could completely suppress the hyperhomocysteinemia induced by choline deficiency resulting from stimulating the homocysteine removal by both remethylation and cystathionine formation." | 7.81 | [Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats]. ( Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q, 2015) |
| "The effect of betaine status on folate deficiency-induced hyperhomocysteinemia was investigated to determine whether folate deficiency impairs homocysteine removal not only by the methionine synthase (MS) pathway but also by the betaine-homocysteine S-methyltransferase (BHMT) pathway." | 7.78 | Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2012) |
| " The hyperhomocysteinemia induced by choline deprivation was effectively suppressed by betaine or methionine supplementation." | 7.74 | Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| "The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces hepatic choline deficiency and to determine whether altered choline homeostasis was causally related to the carcinogenic outcome." | 7.71 | Diethanolamine induces hepatic choline deficiency in mice. ( Gamsky, EA; Hicks, SM; Lehman-McKeeman, LD; Mar, MH; Vassallo, JD; Zeisel, SH, 2002) |
| "Choline is an essential nutrient, but is also formed by de novo synthesis." | 6.47 | Choline and betaine in health and disease. ( Ueland, PM, 2011) |
| "Betaine is an important natural component of rich food sources, especially spinach." | 5.40 | Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. ( Han, F; Huang, ZW; Inakuma, T; Jia, Z; Liu, YQ; Miyashita, T; Sugiyama, K; Sun, LC; Xiang, XS, 2014) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 5.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| "Choline deficiency may contribute to the impaired lean body mass growth and pulmonary and neurocognitive development of preterm infants despite adequate macronutrient supply and weight gain." | 5.01 | Choline and choline-related nutrients in regular and preterm infant growth. ( Bernhard, W; Franz, AR; Poets, CF, 2019) |
| "We examined the effects of betaine, an endogenous and dietary methyl donor essential for the methionine-homocysteine cycle, on oxidative stress, inflammation, apoptosis, and autophagy in methionine-choline deficient diet (MCD)-induced non-alcoholic fatty liver disease (NAFLD)." | 3.91 | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. ( Borozan, S; Dragutinovic, V; Gopcevic, K; Isakovic, A; Jorgacevic, B; Labudovic-Borovic, M; Milenkovic, M; Mladenovic, D; Radosavljevic, T; Tosic, J; Trajkovic, V; Veskovic, M; Vucevic, D, 2019) |
| "The results indicated that betaine or beet could completely suppress the hyperhomocysteinemia induced by choline deficiency resulting from stimulating the homocysteine removal by both remethylation and cystathionine formation." | 3.81 | [Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats]. ( Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q, 2015) |
| "The effect of betaine status on folate deficiency-induced hyperhomocysteinemia was investigated to determine whether folate deficiency impairs homocysteine removal not only by the methionine synthase (MS) pathway but also by the betaine-homocysteine S-methyltransferase (BHMT) pathway." | 3.78 | Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats. ( Liu, Y; Liu, YQ; Morita, T; Sugiyama, K, 2012) |
| " The hyperhomocysteinemia induced by choline deprivation was effectively suppressed by betaine or methionine supplementation." | 3.74 | Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets. ( Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K, 2008) |
| " The addition of choline or carnitine to the choline-deficient diet did not induce a gain in body weight, while the addition of either betaine or methionine to the choline-deficient diet, or of methionine to the choline-deficient diet with choline significantly increased the body weight." | 3.71 | Influence of dietary methionine level on the liver metallothionein mRNA level in rats. ( Aoyama, Y; Kanno, T; Kikuchi, H; Kurasaki, M; Nocianitri, KA; Sakakibara, S, 2002) |
| "The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces hepatic choline deficiency and to determine whether altered choline homeostasis was causally related to the carcinogenic outcome." | 3.71 | Diethanolamine induces hepatic choline deficiency in mice. ( Gamsky, EA; Hicks, SM; Lehman-McKeeman, LD; Mar, MH; Vassallo, JD; Zeisel, SH, 2002) |
| "Choline is an essential nutrient and can also be obtained by de novo synthesis via an oestrogen responsive pathway." | 2.77 | Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. ( Bonham, MP; Duffy, ME; McCormack, JM; McNulty, H; Molloy, AM; Robson, PJ; Scott, JM; Strain, JJ; Ueland, PM; Wallace, JM; Walsh, PM; Ward, M, 2012) |
| "Choline is an essential nutrient, but is also formed by de novo synthesis." | 2.47 | Choline and betaine in health and disease. ( Ueland, PM, 2011) |
| "Betaine is an important natural component of rich food sources, especially spinach." | 1.40 | Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats. ( Han, F; Huang, ZW; Inakuma, T; Jia, Z; Liu, YQ; Miyashita, T; Sugiyama, K; Sun, LC; Xiang, XS, 2014) |
| "Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance." | 1.39 | Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013) |
| "Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland." | 1.29 | Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. ( da Costa, KA; Mar, MH; Zeisel, SH; Zhou, Z, 1995) |
| "Dietary choline deficiency lowered the biological value of casein only slightly." | 1.26 | Hepatic free choline and betaine and the utilization of dietary protein in the choline-deficient rat. ( Arvidson, GA; Asp, NG, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (37.04) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernhard, W | 1 |
| Poets, CF | 1 |
| Franz, AR | 1 |
| Veskovic, M | 1 |
| Mladenovic, D | 1 |
| Milenkovic, M | 1 |
| Tosic, J | 1 |
| Borozan, S | 1 |
| Gopcevic, K | 1 |
| Labudovic-Borovic, M | 1 |
| Dragutinovic, V | 1 |
| Vucevic, D | 1 |
| Jorgacevic, B | 1 |
| Isakovic, A | 1 |
| Trajkovic, V | 1 |
| Radosavljevic, T | 1 |
| Abu Ahmad, N | 1 |
| Raizman, M | 1 |
| Weizmann, N | 1 |
| Wasek, B | 1 |
| Arning, E | 1 |
| Bottiglieri, T | 1 |
| Tirosh, O | 1 |
| Troen, AM | 1 |
| Liu, YQ | 2 |
| Jia, Z | 1 |
| Han, F | 2 |
| Inakuma, T | 1 |
| Miyashita, T | 1 |
| Sugiyama, K | 4 |
| Sun, LC | 1 |
| Xiang, XS | 1 |
| Huang, ZW | 1 |
| Liu, Y | 2 |
| Sun, L | 1 |
| Lu, J | 1 |
| Wang, Q | 1 |
| Huang, Z | 1 |
| Robinson, JL | 1 |
| McBreairty, LE | 1 |
| Randell, EW | 1 |
| Brunton, JA | 1 |
| Bertolo, RF | 1 |
| Setoue, M | 1 |
| Ohuchi, S | 1 |
| Morita, T | 2 |
| Ueland, PM | 3 |
| Wallace, JM | 1 |
| McCormack, JM | 1 |
| McNulty, H | 1 |
| Walsh, PM | 1 |
| Robson, PJ | 1 |
| Bonham, MP | 1 |
| Duffy, ME | 1 |
| Ward, M | 1 |
| Molloy, AM | 1 |
| Scott, JM | 1 |
| Strain, JJ | 1 |
| Nurk, E | 1 |
| Refsum, H | 1 |
| Bjelland, I | 1 |
| Drevon, CA | 1 |
| Tell, GS | 1 |
| Vollset, SE | 1 |
| Engedal, K | 1 |
| Nygaard, HA | 1 |
| Smith, DA | 1 |
| Nocianitri, KA | 1 |
| Sakakibara, S | 1 |
| Kanno, T | 1 |
| Kikuchi, H | 1 |
| Kurasaki, M | 1 |
| Aoyama, Y | 1 |
| Innis, SM | 1 |
| Hasman, D | 1 |
| Gossell-Williams, M | 1 |
| Benjamin, J | 1 |
| Barak, AJ | 2 |
| Kemmy, RJ | 1 |
| Arvidson, GA | 1 |
| Asp, NG | 1 |
| Zeisel, SH | 3 |
| Mar, MH | 3 |
| Zhou, Z | 1 |
| da Costa, KA | 2 |
| Shin, OH | 1 |
| Albright, CD | 1 |
| Citarella, MT | 1 |
| Lehman-McKeeman, LD | 1 |
| Gamsky, EA | 1 |
| Hicks, SM | 1 |
| Vassallo, JD | 1 |
| Tuma, DJ | 1 |
| Wong, ER | 1 |
| Thompson, W | 1 |
| Ketola, HG | 1 |
| Young, RJ | 1 |
| Latshaw, JD | 1 |
| Jensen, LS | 1 |
| Keshavarz, K | 1 |
| Fuller, HL | 1 |
| Nesheim, MC | 1 |
| Norvell, MJ | 1 |
| Ceballos, E | 1 |
| Leach, RM | 1 |
| Rosenfeld, B | 1 |
| Chaplin, MD | 1 |
| Mulford, DJ | 1 |
2 reviews available for betaine and Choline Deficiency
| Article | Year |
|---|---|
Choline and choline-related nutrients in regular and preterm infant growth.
Topics: Betaine; Child Development; Choline; Choline Deficiency; Female; Humans; Infant; Infant, Low Birth W | 2019 |
Choline and betaine in health and disease.
Topics: Animals; Betaine; Choline; Choline Deficiency; Disease; Eating; Health; Humans; Models, Biological; | 2011 |
2 trials available for betaine and Choline Deficiency
| Article | Year |
|---|---|
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Met | 2012 |
Evidence of choline depletion and reduced betaine and dimethylglycine with increased homocysteine in plasma of children with cystic fibrosis.
Topics: Adolescent; Betaine; Case-Control Studies; Child; Choline Deficiency; Cystic Fibrosis; Homocysteine; | 2006 |
23 other studies available for betaine and Choline Deficiency
| Article | Year |
|---|---|
Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease.
Topics: Animals; Autophagy; Betaine; Choline Deficiency; Gastrointestinal Agents; Inflammation; Male; Methio | 2019 |
Betaine attenuates pathology by stimulating lipid oxidation in liver and regulating phospholipid metabolism in brain of methionine-choline-deficient rats.
Topics: Animals; Betaine; Blotting, Western; Choline Deficiency; Lipid Metabolism; Liver; Male; Maze Learnin | 2019 |
Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats.
Topics: Animals; Betaine; Choline Deficiency; Dietary Supplements; Glycine; Hyperhomocysteinemia; Male; Rats | 2014 |
[Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats].
Topics: Amino Acids; Animals; Beta vulgaris; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cho | 2015 |
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficienc | 2016 |
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
Topics: Animals; Betaine; Choline; Choline Deficiency; Cysteine; Dietary Supplements; Growth; Homocysteine; | 2008 |
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies | 2013 |
Effects of betaine supplementation and choline deficiency on folate deficiency-induced hyperhomocysteinemia in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine; Betaine-Homocysteine S- | 2012 |
Influence of dietary methionine level on the liver metallothionein mRNA level in rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Betaine; Blotting, Northern; Body Weight; Choli | 2002 |
Choline: are our university students eating enough?
Topics: Adult; Betaine; Choline Deficiency; Female; Folic Acid; Food Analysis; Humans; Jamaica; Male; Nutrit | 2006 |
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; R | 1982 |
Hepatic free choline and betaine and the utilization of dietary protein in the choline-deficient rat.
Topics: Adipose Tissue; Animals; Betaine; Caseins; Choline; Choline Deficiency; Dietary Proteins; Digestion; | 1982 |
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver.
Topics: Animals; Betaine; Choline; Choline Deficiency; Female; Lactation; Liver; Male; Maternal-Fetal Exchan | 1995 |
Methyl-group donors cannot prevent apoptotic death of rat hepatocytes induced by choline-deficiency.
Topics: Animals; Apoptosis; Betaine; Cell Line; Choline Deficiency; Culture Media; Folic Acid; Liver; Male; | 1997 |
Diethanolamine induces hepatic choline deficiency in mice.
Topics: Administration, Cutaneous; Animals; Betaine; Carcinogens; Choline Deficiency; Dose-Response Relation | 2002 |
A simplified procedure for the determination of betaine in liver.
Topics: Animals; Betaine; Choline Deficiency; Liver; Male; Rats; Spectrophotometry | 1979 |
Choline oxidation and labile methyl groups in normal and choline-deficient rat liver.
Topics: Acetates; Alcohol Oxidoreductases; Aldehydes; Animals; Autoradiography; Betaine; Carbon Isotopes; Ch | 1972 |
The need for dietary choline by young Japanese quail.
Topics: Animal Feed; Animals; Betaine; Carnitine; Choline; Choline Deficiency; Coturnix; Diet; Ethanolamines | 1973 |
Choline deficiency and synthesis of choline from precursors in mature Japanese quail.
Topics: Age Factors; Amino Alcohols; Animal Nutritional Physiological Phenomena; Animals; Betaine; Birds; Ca | 1972 |
Relationship of arginine and methionine to creatine formation in chicks.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Arginine; Betaine; Body Weight; Ch | 1971 |
The effect of choline supplementation of diets for growing pullets and laying hens.
Topics: Amino Alcohols; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Betaine; Body Weig | 1971 |
Effects of a single choline-deficient meal on the phospholipids of hepatic particulate lipid of the rat.
Topics: Animals; Betaine; Choline Deficiency; Chromatography, Thin Layer; Liver; Male; Phosphatidylcholines; | 1968 |
Amino alcohols and methyl donors in rats fed low choline diets containing added cholesterol.
Topics: Amino Alcohols; Animals; Betaine; Cholesterol; Choline Deficiency; Dietary Fats; Fats; Liver; Methio | 1966 |