betaine has been researched along with Chemical and Drug Induced Liver Injury in 22 studies
glycine betaine : The amino acid betaine derived from glycine.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study aimed to investigate the role of MIF in oxidative stress and inflammation in the liver, and modulatory effects of betaine on MIF in thioacetamide (TAA)-induced chronic hepatic damage in mice." | 8.02 | The Role of MIF in Hepatic Function, Oxidative Stress, and Inflammation in Thioacetamide-induced Liver Injury in Mice: Protective Effects of Betaine. ( Gopčević, K; Ješić, R; Jorgačević, B; Mladenović, D; Radosavljević, T; Rovčanin, B; Samardžić, J; Stanković, S; Vesković, M; Vučević, D; Vukićević, D, 2021) |
| "Our study aimed to investigate the role of MIF in oxidative stress and inflammation in the liver, and modulatory effects of betaine on MIF in thioacetamide (TAA)-induced chronic hepatic damage in mice." | 4.02 | The Role of MIF in Hepatic Function, Oxidative Stress, and Inflammation in Thioacetamide-induced Liver Injury in Mice: Protective Effects of Betaine. ( Gopčević, K; Ješić, R; Jorgačević, B; Mladenović, D; Radosavljević, T; Rovčanin, B; Samardžić, J; Stanković, S; Vesković, M; Vučević, D; Vukićević, D, 2021) |
| "Betaine is a kind of water-soluble quaternary amine-type alkaloid widely existing in food, such as wheat germ, beet, spinach, shrimp and wolfberry." | 2.72 | Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms. ( Dai, S; Gong, L; Li, Y; Ma, C; Wang, C, 2021) |
| "Pre-treatment with betaine reduced serum aminotransferases (ALT and AST), and lowered hepatic concentrations of lipid peroxides, nitrite and TNF-α while increased SOD, GSH, catalase, and GSH-Px concentrations." | 1.51 | Inhibition of NF-κB and the oxidative stress -dependent caspase-3 apoptotic pathway by betaine supplementation attenuates hepatic injury mediated by cisplatin in rats. ( Ali, HM; Attia, MMA; Attia, NM; Fadda, LM; Hagar, H; Husain, S, 2019) |
| "Betaine (500 mg/kg) was chosen as the most effective dose to rescue APAP hepatotoxicity in mice." | 1.48 | Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability. ( Kalantari, H; Khodayar, MJ; Khorsandi, L; Rashno, M; Zeidooni, L, 2018) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Taurine or betaine pretreatment in lipopolysaccharide-injected rats caused significant decreases in plasma transaminase activities and hepatic malondialdehyde and DC levels, and significant increases in glutathione and alpha-tocopherol (not betaine) levels without changing ascorbic acid levels and SOD and glutathione peroxidase activities in the liver." | 1.33 | The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. ( Aykaç-Toker, G; Balkan, J; Doğru-Abbasoğlu, S; Parldar, FH; Uysal, M, 2005) |
| "Betaine treated either 4 or 24 hr prior to sacrifice did not alter the hepatic contents of cytochrome P-450, cytochrome b5, or NADPH cytochrome P-450 reductase activity." | 1.30 | Effects of singly administered betaine on hepatotoxicity of chloroform in mice. ( Kim, SK; Kim, YC, 1998) |
| "Carbon tetrachloride-injected rats were given liquid diets with and without betaine for 7 d." | 1.30 | Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. ( Barak, AJ; Beckenhauer, HC; Junnila, M; Rahko, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Wang, C | 1 |
| Ma, C | 1 |
| Gong, L | 1 |
| Dai, S | 1 |
| Li, Y | 1 |
| Hagar, H | 1 |
| Husain, S | 1 |
| Fadda, LM | 1 |
| Attia, NM | 1 |
| Attia, MMA | 1 |
| Ali, HM | 1 |
| Khodayar, MJ | 2 |
| Kalantari, H | 2 |
| Khorsandi, L | 2 |
| Rashno, M | 2 |
| Zeidooni, L | 2 |
| Vukićević, D | 1 |
| Rovčanin, B | 1 |
| Gopčević, K | 1 |
| Stanković, S | 1 |
| Vučević, D | 1 |
| Jorgačević, B | 1 |
| Mladenović, D | 1 |
| Vesković, M | 1 |
| Samardžić, J | 1 |
| Ješić, R | 1 |
| Radosavljević, T | 1 |
| Abdel-Daim, MM | 1 |
| Abdellatief, SA | 1 |
| Zhang, W | 1 |
| Wang, LW | 1 |
| Wang, LK | 1 |
| Li, X | 1 |
| Zhang, H | 1 |
| Luo, LP | 1 |
| Song, JC | 1 |
| Gong, ZJ | 1 |
| Ahn, M | 1 |
| Park, JS | 1 |
| Chae, S | 1 |
| Kim, S | 1 |
| Moon, C | 1 |
| Hyun, JW | 1 |
| Shin, T | 1 |
| Başaran-Küçükgergin, C | 1 |
| Bingül, I | 1 |
| Tekkeşin, MS | 1 |
| Olgaç, V | 1 |
| Doğru-Abbasoğlu, S | 2 |
| Uysal, M | 2 |
| Okada, T | 1 |
| Kawakami, S | 1 |
| Nakamura, Y | 1 |
| Han, KH | 1 |
| Ohba, K | 1 |
| Aritsuka, T | 1 |
| Uchino, H | 1 |
| Shimada, K | 1 |
| Sekikawa, M | 1 |
| Ishii, H | 1 |
| Fukushima, M | 1 |
| Kim, SK | 2 |
| Kim, YC | 3 |
| Balkan, J | 1 |
| Parldar, FH | 1 |
| Aykaç-Toker, G | 1 |
| Murakami, T | 1 |
| Nagamura, Y | 1 |
| Hirano, K | 1 |
| Junnila, M | 1 |
| Barak, AJ | 1 |
| Beckenhauer, HC | 1 |
| Rahko, T | 1 |
2 reviews available for betaine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms.
Topics: Animals; Betaine; Chemical and Drug Induced Liver Injury; Humans; Liver Diseases; Liver Diseases, Al | 2021 |
20 other studies available for betaine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Inhibition of NF-κB and the oxidative stress -dependent caspase-3 apoptotic pathway by betaine supplementation attenuates hepatic injury mediated by cisplatin in rats.
Topics: Animals; Aspartate Aminotransferases; Betaine; Caspase 3; Chemical and Drug Induced Liver Injury; Ci | 2019 |
Upregulation of Nrf2-related cytoprotective genes expression by acetaminophen-induced acute hepatotoxicity in mice and the protective role of betaine.
Topics: Acetaminophen; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Betaine; Chem | 2020 |
The Role of MIF in Hepatic Function, Oxidative Stress, and Inflammation in Thioacetamide-induced Liver Injury in Mice: Protective Effects of Betaine.
Topics: Animals; Betaine; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Ch | 2021 |
Attenuating effects of caffeic acid phenethyl ester and betaine on abamectin-induced hepatotoxicity and nephrotoxicity.
Topics: Animals; Antioxidants; Betaine; Caffeic Acids; Catalase; Chemical and Drug Induced Liver Injury; Cre | 2018 |
Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability.
Topics: Acetaminophen; Animals; Betaine; Catalase; Chemical and Drug Induced Liver Injury; Electron Transpor | 2018 |
Betaine protects against high-fat-diet-induced liver injury by inhibition of high-mobility group box 1 and Toll-like receptor 4 expression in rats.
Topics: Animals; Betaine; Chemical and Drug Induced Liver Injury; Cytokines; Dietary Fats; Fatty Liver; Fema | 2013 |
Hepatoprotective effects of Lycium chinense Miller fruit and its constituent betaine in CCl4-induced hepatic damage in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Betaine; Carbon Tetrachlor | 2014 |
Effects of carnosine, taurine, and betaine pretreatments on diethylnitrosamine-induced oxidative stress and tissue injury in rat liver.
Topics: Animals; Antioxidants; Betaine; Biomarkers; Carcinogens, Environmental; Carnosine; Chemical and Drug | 2016 |
Amelioration of D-galactosamine-induced acute liver injury in rats by dietary supplementation with betaine derived from sugar beet molasses.
Topics: Adenosylhomocysteinase; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransfer | 2011 |
Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice.
Topics: Amino Acids, Sulfur; Animals; Betaine; Chemical and Drug Induced Liver Injury; Chloroform; Cysteine; | 2005 |
The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats.
Topics: Animals; Antioxidants; Betaine; Chemical and Drug Induced Liver Injury; Lipopolysaccharides; Liver D | 2005 |
The recovering effect of betaine on carbon tetrachloride-induced liver injury.
Topics: Alanine Transaminase; Animals; Betaine; Carbon Tetrachloride; Cell Nucleus; Chemical and Drug Induce | 1998 |
Effects of singly administered betaine on hepatotoxicity of chloroform in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Betaine; Chemical and Drug Induced Liver | 1998 |
Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats.
Topics: Administration, Oral; Animals; Betaine; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced | 1998 |