betaine has been researched along with Brain Edema in 3 studies
glycine betaine : The amino acid betaine derived from glycine.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical features of untreated CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events." | 1.42 | Successive MRI Findings of Reversible Cerebral White Matter Lesions in a Patient with Cystathionine β-Synthase Deficiency. ( Asano, T; Fukao, T; Kawamoto, M; Kawamoto, N; Kimura, T; Matsui, E; Sasai, H; Shimozawa, N; Yamamoto, T, 2015) |
| "We conclude that the cerebral edema was most likely precipitated by the betaine therapy, although the exact mechanism is uncertain." | 1.31 | Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency. ( Allen, RH; Braverman, N; Geraghty, MT; Kashani, AH; Mudd, SH; Okoh, J; Pomper, M; Stabler, SP; Tangerman, A; Wagner, C; Yaghmai, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sasai, H | 1 |
| Shimozawa, N | 1 |
| Asano, T | 1 |
| Kawamoto, N | 1 |
| Yamamoto, T | 1 |
| Kimura, T | 1 |
| Kawamoto, M | 1 |
| Matsui, E | 1 |
| Fukao, T | 1 |
| Devlin, AM | 1 |
| Hajipour, L | 1 |
| Gholkar, A | 1 |
| Fernandes, H | 1 |
| Ramesh, V | 1 |
| Morris, AA | 1 |
| Yaghmai, R | 1 |
| Kashani, AH | 1 |
| Geraghty, MT | 1 |
| Okoh, J | 1 |
| Pomper, M | 1 |
| Tangerman, A | 1 |
| Wagner, C | 1 |
| Stabler, SP | 1 |
| Allen, RH | 1 |
| Mudd, SH | 1 |
| Braverman, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria[NCT00283387] | Phase 2 | 15 participants (Actual) | Interventional | 2007-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The patients were randomly assigned oral betaine or placebo for 2 months, followed by a 2 month washout. Each patient then received the alternate study medication for 2 months.~Urinary Oxalate Excretion was measured by oxalate oxidase. Two 24 hour urine collections were obtained at baseline, and during the eighth week of each study period." (NCT00283387)
Timeframe: baseline, 2 months, 6 months
| Intervention | umol/mg (Mean) |
|---|---|
| Betaine | 1.43 |
| Placebo | 1.04 |
3 other studies available for betaine and Brain Edema
| Article | Year |
|---|---|
Successive MRI Findings of Reversible Cerebral White Matter Lesions in a Patient with Cystathionine β-Synthase Deficiency.
Topics: Betaine; Brain; Brain Edema; Cell Membrane; Diet, Protein-Restricted; Diffusion Magnetic Resonance I | 2015 |
Cerebral edema associated with betaine treatment in classical homocystinuria.
Topics: Betaine; Brain Edema; Child, Preschool; Craniotomy; Cystathionine beta-Synthase; Decompression, Surg | 2004 |
Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency.
Topics: Betaine; Brain Edema; Child; Child, Preschool; Female; Homocystinuria; Humans; Infant; Infant, Newbo | 2002 |