Page last updated: 2024-10-16

betaine and Apoplexy

betaine has been researched along with Apoplexy in 11 studies

glycine betaine : The amino acid betaine derived from glycine.

Research Excerpts

ExcerptRelevanceReference
"We aimed to prospectively investigate the relationships of circulating choline and betaine with cardiovascular events and recurrent stroke in patients with ischemic stroke."8.02Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke. ( Bu, X; Che, B; Du, J; He, J; Ju, Z; Miao, M; Peng, H; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2021)
"Among our African-American participants, higher dietary choline intake was associated with a lower risk of incident ischemic stroke, and thus putative dietary benefits."7.88Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. ( Bidulescu, A; Dibaba, DT; Millard, HR; Musani, SK; Talegawkar, SA; Taylor, HA; Tucker, KL, 2018)
"Increased TMAO was associated with higher stroke risk in the community-based population, whereas the TMAO precursors carnitine, choline, betaine, and TML were not associated."4.31Associations of plasma TMAO and its precursors with stroke risk in the general population: A nested case-control study. ( Gu, S; Liu, D; Ma, Z; Zhou, Z; Zuo, H, 2023)
"We aimed to prospectively investigate the relationships of circulating choline and betaine with cardiovascular events and recurrent stroke in patients with ischemic stroke."4.02Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke. ( Bu, X; Che, B; Du, J; He, J; Ju, Z; Miao, M; Peng, H; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zhong, C, 2021)
"Among our African-American participants, higher dietary choline intake was associated with a lower risk of incident ischemic stroke, and thus putative dietary benefits."3.88Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. ( Bidulescu, A; Dibaba, DT; Millard, HR; Musani, SK; Talegawkar, SA; Taylor, HA; Tucker, KL, 2018)
"Betaine is an osmolyte, supplies methyl groups, and controls plasma homocysteine."2.74Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. ( Chambers, ST; Elmslie, JL; Fink, JN; George, PM; Lever, M; Richards, AM; Scott, RS; Slow, S, 2009)
"TMAO was associated with lacunar stroke but not other ischemic stroke subtypes in a model adjusted for age, sex, hypertension, diabetes, and smoking (OR, 1."1.91Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke. ( Ament, Z; Bevers, MB; Bhave, VM; Couch, CA; Garcia Guarniz, AL; Irvin, MR; Kijpaisalratana, N; Kimberly, WT, 2023)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's6 (54.55)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Liu, D1
Gu, S1
Zhou, Z2
Ma, Z1
Zuo, H1
Kijpaisalratana, N1
Ament, Z1
Bevers, MB1
Bhave, VM1
Garcia Guarniz, AL1
Couch, CA1
Irvin, MR1
Kimberly, WT1
Zhong, C1
Miao, M1
Che, B1
Du, J1
Wang, A1
Peng, H1
Bu, X1
Zhang, J1
Ju, Z1
Xu, T1
He, J1
Zhang, Y1
Yu, W1
Xu, C1
Li, G1
Hong, W1
Xiao, C1
Zhao, Y1
Cai, Y1
Huang, M1
Jin, J1
Narayanan, D1
Luvai, A1
Barski, R1
Sharma, R1
Nagata, C1
Wada, K1
Tamura, T1
Konishi, K1
Kawachi, T1
Tsuji, M1
Nakamura, K1
Skagen, K1
Trøseid, M1
Ueland, T1
Holm, S1
Abbas, A1
Gregersen, I1
Kummen, M1
Bjerkeli, V1
Reier-Nilsen, F1
Russell, D1
Svardal, A1
Karlsen, TH1
Aukrust, P1
Berge, RK1
Hov, JE1
Halvorsen, B1
Skjelland, M1
Millard, HR1
Musani, SK1
Dibaba, DT1
Talegawkar, SA1
Taylor, HA1
Tucker, KL1
Bidulescu, A1
Liu, P2
Li, R1
Antonov, AA1
Wang, L2
Li, W1
Hua, Y1
Guo, H1
Chen, L1
Tian, Y1
Xu, F1
Zhang, Z1
Zhu, Y1
Huang, Y1
Lever, M1
George, PM1
Slow, S1
Elmslie, JL1
Scott, RS1
Richards, AM1
Fink, JN1
Chambers, ST1
Hewawasam, P1
Ding, M1
Chen, N1
King, D1
Knipe, J1
Pajor, L1
Ortiz, A1
Gribkoff, VK1
Starrett, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Inner Mongolia Stroke Project A Randomized Controlled Trial of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke in China[NCT01840072]4,071 participants (Actual)Interventional2009-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

A Combination of All-cause Mortality and Major Disability at the 3-month Post-treatment Follow-up.

Major disability was defined as a score of 3 to 5 on the modified Rankin Scale at 3 months after randomization. Scores on the modified Rankin Scale range from 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability (ie, bedridden, incontinent, or requiring constant nursing care and attention); and a score of 6 indicating death (NCT01840072)
Timeframe: 3 months

InterventionParticipants (Count of Participants)
Usual Care502
Active Antihypertensive Treatment500

A Combination of Death Within 14 Days After Randomization and Major Disability at 14 Days or at Hospital Discharge if Earlier Than 14 Days.

Major disability was defined as a score of 3 to 5 on the modified Rankin Scale at 14 days after randomization. Scores on the modified Rankin Scale range from 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability (ie, bedridden, incontinent, or requiring constant nursing care and attention); and a score of 6 indicating death. (NCT01840072)
Timeframe: 2 weeks

Interventionparticipants (Number)
Usual Care681
Active Antihypertensive Treatment683

Cognitive Function (Montreal Cognitive Assessment)

Cognitive function was measured by Montreal Cognitive Assessment at 3 months after randomization. The MoCA is a 30-item test that evaluates the following seven cognitive domains: visuospatial/executive functions, naming, memory, attention, language, abstraction, and orientation. One point is added for participants with education <12 years. Scores on the MoCA range from 0 to 30 and cognitive impairment was defined as a score of <26. (NCT01840072)
Timeframe: Three months

InterventionMoCA score (Median)
Usual Care22
Active Antihypertensive Treatment22

Cognitive Function (the Mini-Mental State Examination)

Cognitive function was measured by the Mini-Mental State Examination at 3 months after randomization. The MMSE contains 20 items that test cognitive performance in domains including orientation, registration, attention and calculation, recall, language, and visual construction. MMSE scores were divided into three ordinal categories: 24-30 (no cognitive impairment), 19-23 (mild cognitive impairment), and 0-17 (severe cognitive impairment). (NCT01840072)
Timeframe: Three months

InterventionMMSE score (Median)
Usual Care26
Active Antihypertensive Treatment26

Long-term Neurological and Functional Status

Those patients who were still alive at hospital discharge were contacted by telephone to set up a follow-up clinical visit. Neurological function was assessed by the modified Rankin scale at the 3-month post-treatment follow-up visit. Scores on the modified Rankin Scale range from 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability (ie, bedridden, incontinent, or requiring constant nursing care and attention); and a score of 6 indicating death. Major disability was defined as a score of 3 to 5 on the modified Rankin Scale. (NCT01840072)
Timeframe: Three months

InterventionScore on modified Rankin scale (Median)
Usual Care1.0
Active Antihypertensive Treatment1.0

Mortality

Those patients who are still alive at hospital discharge will be contacted by telephone to set up a follow-up clinical visit. Information on clinical deaths will be obtained. (NCT01840072)
Timeframe: 3 months

Interventionparticipants (Number)
Active Antihypertensive Treatment68
Usual Care54

Other Vascular Events

Those patients who are still alive at hospital discharge will be contacted by telephone to set up a follow-up clinical visit. Information of vascular events, such as myocardial infarction, will be collected. (NCT01840072)
Timeframe: 3 months

Interventionparticipants (Number)
Usual Care59
Active Antihypertensive Treatment48

Recurrent Stroke

Those patients who are still alive at hospital discharge will be contacted by telephone to set up a follow-up clinical visit. Information of recurrent stroke will be collected. (NCT01840072)
Timeframe: 3 months

Interventionparticipants (Number)
Active Antihypertensive Treatment28
Usual Care43

Trials

1 trial available for betaine and Apoplexy

ArticleYear
Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine.
    Cardiovascular drugs and therapy, 2009, Volume: 23, Issue:5

    Topics: Acute Coronary Syndrome; Aged; Betaine; Clofibric Acid; Cohort Studies; Diabetes Complications; Fema

2009

Other Studies

10 other studies available for betaine and Apoplexy

ArticleYear
Associations of plasma TMAO and its precursors with stroke risk in the general population: A nested case-control study.
    Journal of internal medicine, 2023, Volume: 293, Issue:1

    Topics: Betaine; Carnitine; Case-Control Studies; Choline; Humans; Stroke

2023
Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.
    JAMA network open, 2023, 08-01, Volume: 6, Issue:8

    Topics: Aged; Betaine; Carnitine; Cerebral Small Vessel Diseases; Choline; Cross-Sectional Studies; Female;

2023
Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke.
    The American journal of clinical nutrition, 2021, 10-04, Volume: 114, Issue:4

    Topics: Aged; Betaine; Cardiovascular Diseases; Case-Control Studies; Choline; Female; Humans; Lipotropic Ag

2021
Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients.
    Journal of pharmaceutical and biomedical analysis, 2018, Apr-15, Volume: 152

    Topics: Aged; Betaine; Choline; Chromatography, High Pressure Liquid; Female; Humans; Male; Methylamines; Pl

2018
Stroke in a young man.
    BMJ (Clinical research ed.), 2013, Jul-15, Volume: 347

    Topics: Adult; Betaine; Cystathionine beta-Synthase; Diet, Protein-Restricted; Homocysteine; Homocystinuria;

2013
Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women.
    The Journal of nutrition, 2015, Volume: 145, Issue:8

    Topics: Adult; Animals; Asian People; Betaine; Choline; Coronary Disease; Diet; Female; Humans; Male; Middle

2015
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis.
    Atherosclerosis, 2016, Volume: 247

    Topics: Aged; Betaine; Biomarkers; Carnitine; Carotid Stenosis; Case-Control Studies; Cause of Death; Chroma

2016
Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study.
    European journal of nutrition, 2018, Volume: 57, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Betaine; Black People; Cardiovascular Diseases; Choline; Coronary Di

2018
Discovery of Metabolite Biomarkers for Acute Ischemic Stroke Progression.
    Journal of proteome research, 2017, 02-03, Volume: 16, Issue:2

    Topics: Aged; Betaine; Biomarkers; Disease Progression; Early Diagnosis; Female; Humans; Isoleucine; Male; M

2017
Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.
    Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10

    Topics: Animals; Betaine; Blood; Carnitine; Crystallization; Dose-Response Relationship, Drug; Drug Stabilit

2003