Page last updated: 2024-10-16

betaine and Aging

betaine has been researched along with Aging in 21 studies

glycine betaine : The amino acid betaine derived from glycine.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Betaine is an important human nutrient obtained from various foods."5.33Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases. ( Chung, HY; Go, EK; Jung, KJ; Kim, JY; Yu, BP, 2005)
"Choline is an essential nutrient and can also be obtained by de novo synthesis via an oestrogen responsive pathway."2.77Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. ( Bonham, MP; Duffy, ME; McCormack, JM; McNulty, H; Molloy, AM; Robson, PJ; Scott, JM; Strain, JJ; Ueland, PM; Wallace, JM; Walsh, PM; Ward, M, 2012)
"Betaine promotes muscle protein synthesis via tethering mammalian target of rapamycin complex1 protein kinase (mTORC1) on the lysosomal membrane thereby activating mTORC1 signaling."1.62Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level. ( Chen, S; Fang, AP; He, TT; Hou, MJ; Long, JA; Lu, XT; Luo, Y; Tan, XY; Tang, ZH; Yishake, D; Zhong, RH; Zhu, HL, 2021)
"Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance."1.39Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013)
"Carnitine biosynthesis was assessed in human infants by measuring changes in plasma carnitine concentration and rates of urinary carnitine excretion after infants were fed carnitine-free formulas with and without added epsilon-N-trimethyl-L-lysine or gamma-butyrobetaine."1.27gamma-Butyrobetaine hydroxylase activity is not rate limiting for carnitine biosynthesis in the human infant. ( Olson, AL; Rebouche, CJ, 1987)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's0 (0.00)18.2507
2000's5 (23.81)29.6817
2010's8 (38.10)24.3611
2020's4 (19.05)2.80

Authors

AuthorsStudies
Long, JA2
Zhong, RH2
Chen, S2
Wang, F1
Luo, Y2
Lu, XT2
Yishake, D2
Chen, YM1
Fang, AP2
Zhu, HL2
He, TT1
Tan, XY1
Hou, MJ1
Tang, ZH1
Craven, H1
McGuinness, D1
Buchanan, S1
Galbraith, N1
McGuinness, DH1
Jones, B1
Combet, E1
Mafra, D1
Bergman, P1
Ellaway, A1
Stenvinkel, P1
Ijaz, UZ1
Shiels, PG1
Gillies, NA1
Franzke, B1
Wessner, B1
Schober-Halper, B1
Hofmann, M1
Oesen, S1
Tosevska, A1
Strasser, EM1
Roy, NC1
Milan, AM1
Cameron-Smith, D1
Wagner, KH1
Jarak, I1
Almeida, S1
Carvalho, RA1
Sousa, M1
Barros, A1
Alves, MG1
Oliveira, PF1
Hoffman, JM1
Ross, C1
Tran, V1
Promislow, DEL1
Tardif, S1
Jones, DP1
Lee, EK1
Jang, EJ1
Jung, KJ3
Kim, DH1
Yu, BP3
Chung, HY3
Çoban, J1
Bingül, I1
Yesil-Mizrak, K1
Dogru-Abbasoglu, S1
Oztezcan, S1
Uysal, M1
Hu, Y1
Sun, Q1
Zong, Y1
Liu, J1
Idriss, AA1
Omer, NA1
Zhao, R1
Cholewa, JM1
Dardevet, D1
Lima-Soares, F1
de Araújo Pessôa, K1
Oliveira, PH1
Dos Santos Pinho, JR1
Nicastro, H1
Xia, Z1
Cabido, CE1
Zanchi, NE1
Clow, KA1
Treberg, JR1
Brosnan, ME1
Brosnan, JT1
Wallace, JM1
McCormack, JM1
McNulty, H1
Walsh, PM1
Robson, PJ1
Bonham, MP1
Duffy, ME1
Ward, M1
Molloy, AM1
Scott, JM1
Ueland, PM2
Strain, JJ1
Nurk, E1
Refsum, H1
Bjelland, I1
Drevon, CA1
Tell, GS1
Vollset, SE1
Engedal, K1
Nygaard, HA1
Smith, DA1
Go, EK2
Kim, JY1
Sparks, JD1
Collins, HL1
Chirieac, DV1
Cianci, J1
Jokinen, J1
Sowden, MP1
Galloway, CA1
Sparks, CE1
Pillai, PB1
Fanatico, AC1
Blair, ME1
Emmert, JL1
Kim, JM1
Lim, H1
Lim, HK1
Barak, AJ1
Kemmy, RJ1
Olson, AL1
Rebouche, CJ1
Zapadniuk, VI1
Panteleĭmonova, TN1
Finkelstein, JD1
Kyle, W1
Harris, BJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults[NCT06157385]46 participants (Anticipated)Interventional2023-05-06Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for betaine and Aging

ArticleYear
Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response.
    Amino acids, 2017, Volume: 49, Issue:5

    Topics: Aging; Antioxidants; Betaine; Dietary Proteins; Dietary Supplements; Exercise; Glycine; Humans; Hypo

2017

Trials

3 trials available for betaine and Aging

ArticleYear
Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study.
    European journal of nutrition, 2022, Volume: 61, Issue:1

    Topics: Aged; Aging; Betaine; Carbon; Cardiovascular Diseases; Choline; Dietary Supplements; Female; Homocys

2022
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
    The British journal of nutrition, 2012, Volume: 108, Issue:7

    Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Dietary Supplements; Double-Blind Met

2012
Homocysteine remethylation in broilers fed surfeit choline or betaine and varying levels and sources of methionine from eight to twenty-two days of age.
    Poultry science, 2006, Volume: 85, Issue:10

    Topics: Aging; Animal Feed; Animals; Betaine; Chickens; Choline; Dose-Response Relationship, Drug; Homocyste

2006

Other Studies

17 other studies available for betaine and Aging

ArticleYear
Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study.
    The British journal of nutrition, 2021, 02-28, Volume: 125, Issue:4

    Topics: Aging; Betaine; Body Composition; Body Mass Index; China; Cohort Studies; Diet; Female; Humans; Male

2021
Betaine Delayed Muscle Loss by Attenuating Samtor Complex Inhibition for mTORC1 Signaling Via Increasing SAM Level.
    Molecular nutrition & food research, 2021, Volume: 65, Issue:15

    Topics: Aging; Animals; Betaine; Gene Expression Regulation; Intracellular Membranes; Intracellular Signalin

2021
Socioeconomic position links circulatory microbiota differences with biological age.
    Scientific reports, 2021, 06-16, Volume: 11, Issue:1

    Topics: Adult; Aged; Aging; Bacteria; Betaine; Female; Humans; Life Style; Male; Methylamines; Middle Aged;

2021
Senescence and declining reproductive potential: Insight into molecular mechanisms through testicular metabolomics.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:10

    Topics: Aging; Animals; Betaine; Creatine; Fertility; Glutathione; Magnetic Resonance Spectroscopy; Male; Me

2018
The metabolome as a biomarker of mortality risk in the common marmoset.
    American journal of primatology, 2019, Volume: 81, Issue:2

    Topics: Aging; Animal Husbandry; Animals; Betaine; Biomarkers; Callithrix; Female; Male; Metabolome; Methion

2019
Betaine attenuates lysophosphatidylcholine-mediated adhesion molecules in aged rat aorta: modulation of the nuclear factor-κB pathway.
    Experimental gerontology, 2013, Volume: 48, Issue:5

    Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta; Betaine; Cell Adhesion

2013
Effects of carnosine plus vitamin E and betaine treatments on oxidative stress in some tissues of aged rats.
    Current aging science, 2013, Volume: 6, Issue:2

    Topics: Aging; Animals; Antioxidants; Betaine; Body Weight; Brain; Carnosine; Glutathione; Lipid Peroxidatio

2013
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
    General and comparative endocrinology, 2017, 05-15, Volume: 246

    Topics: Aging; Animals; Animals, Newborn; Anti-Inflammatory Agents; Betaine; Blotting, Western; Chickens; Ch

2017
Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis.
    The Journal of nutrition, 2008, Volume: 138, Issue:9

    Topics: Aging; Animals; Betaine; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Female; Male;

2008
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
    The British journal of nutrition, 2013, Feb-14, Volume: 109, Issue:3

    Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies

2013
Betaine suppresses proinflammatory signaling during aging: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinases.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2005, Volume: 60, Issue:10

    Topics: Aging; Animals; Anti-Inflammatory Agents; Betaine; Cells, Cultured; Cyclooxygenase 2; Enzyme Activat

2005
Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase.
    The Biochemical journal, 2006, Apr-15, Volume: 395, Issue:2

    Topics: Aging; Animals; Apolipoproteins B; Betaine; Betaine-Homocysteine S-Methyltransferase; Diet; Enzyme I

2006
Betaine modulates age-related NF-kappaB by thiol-enhancing action.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:12

    Topics: Aging; Animals; Antioxidants; Betaine; Blotting, Western; Body Weight; Cell Nucleus; Cells, Cultured

2007
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
    Drug-nutrient interactions, 1982, Volume: 1, Issue:4

    Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; R

1982
gamma-Butyrobetaine hydroxylase activity is not rate limiting for carnitine biosynthesis in the human infant.
    The Journal of nutrition, 1987, Volume: 117, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Betaine; Carnitine; Child, Preschool; Female; gamma-Butyrobetaine Di

1987
[Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:7

    Topics: Aging; Animals; Arteriosclerosis; Betaine; Bile; Cholagogues and Choleretics; Cholic Acids; Dehydroc

1987
Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue.
    Archives of biochemistry and biophysics, 1971, Volume: 146, Issue:1

    Topics: Aging; Alloxan; Animals; Betaine; Chromatography, Gel; Cycloheximide; Cysteine; Dactinomycin; Dietar

1971