Page last updated: 2024-10-16

betaine and Achlorhydria

betaine has been researched along with Achlorhydria in 7 studies

glycine betaine : The amino acid betaine derived from glycine.

Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.

Research Excerpts

ExcerptRelevanceReference
"Therefore, BHCl reversed the impact of hypochlorhydria on dasatinib drug exposure and may be an effective strategy to mitigate potential drug-drug interactions for drugs that exhibit pH-dependent solubility and are administered orally under hypochlorhydric conditions."2.79The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. ( Benet, LZ; Budha, N; Dean, B; Ding, X; Dresser, MJ; Frassetto, LA; Frymoyer, A; Jin, JY; Salphati, L; Smelick, GS; Ware, JA; Yago, MR, 2014)
"Betaine HCl was well tolerated by all subjects."2.78Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. ( Benet, LZ; Budha, NR; Dresser, MJ; Frassetto, LA; Frymoyer, AR; Smelick, GS; Ware, JA; Yago, MR, 2013)
"Famotidine pretreatment lowered GDC-0941 exposure by 5-fold, and decreased dasatinib measurable concentrations 30-fold, compared to the pentagastrin-treated dogs."1.39Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl. ( Dalziel, G; Dean, B; Pang, J; Salphati, L; Ware, JA, 2013)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pang, J1
Dalziel, G1
Dean, B2
Ware, JA3
Salphati, L2
Yago, MR3
Frymoyer, AR1
Smelick, GS2
Frassetto, LA3
Budha, NR1
Dresser, MJ2
Benet, LZ3
Frymoyer, A1
Ding, X1
Budha, N1
Jin, JY1
Faber, KP1
Wu, HF1
Xu, X1
Kadiyala, P1
Lentini, J1
Taure, C1
Escala, C1
Sharp, GS2
Helsper, JT1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Gastric pH on the Pharmacokinetics of Dasatinib in Healthy Volunteers[NCT01398046]Phase 110 participants (Actual)Interventional2011-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for betaine and Achlorhydria

ArticleYear
Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.
    Molecular pharmaceutics, 2013, Nov-04, Volume: 10, Issue:11

    Topics: Achlorhydria; Adult; Anti-Ulcer Agents; Betaine; Female; Healthy Volunteers; Humans; Hydrogen-Ion Co

2013
The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.
    The AAPS journal, 2014, Volume: 16, Issue:6

    Topics: Absorption, Physiological; Achlorhydria; Adult; Antineoplastic Agents; Area Under Curve; Betaine; Cr

2014
Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.
    Pharmaceutical research, 2017, Volume: 34, Issue:3

    Topics: Absorption, Physiological; Achlorhydria; Administration, Oral; Adult; Atazanavir Sulfate; Betaine; C

2017

Other Studies

4 other studies available for betaine and Achlorhydria

ArticleYear
Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl.
    Molecular pharmaceutics, 2013, Nov-04, Volume: 10, Issue:11

    Topics: Absorption; Achlorhydria; Animals; Antineoplastic Agents; Betaine; Dasatinib; Dogs; Famotidine; Gast

2013
[Hypochylia in the aged. Its treatment with an acid combination of pepsin and vitamins].
    Revista espanola de las enfermedades del aparato digestivo, 1970, Jun-01, Volume: 31, Issue:5

    Topics: Achlorhydria; Aged; Betaine; Citrates; Female; Humans; Hydrochloric Acid; Lactates; Male; Niacinamid

1970
Oral manifestations of systemic disease. Regimen of treatment.
    Oral surgery, oral medicine, and oral pathology, 1967, Volume: 23, Issue:6

    Topics: Achlorhydria; Betaine; Deglutition Disorders; Dietary Proteins; Disease; Drug-Related Side Effects a

1967
Treatment for low tolerance to dentures: supplemental report.
    The Journal of prosthetic dentistry, 1967, Volume: 17, Issue:3

    Topics: Achlorhydria; Betaine; Cellulose; Dentures; Humans; Liver Extracts; Mouth, Edentulous; Pepsin A; Qua

1967