betaine has been researched along with Achlorhydria in 7 studies
glycine betaine : The amino acid betaine derived from glycine.
Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, BHCl reversed the impact of hypochlorhydria on dasatinib drug exposure and may be an effective strategy to mitigate potential drug-drug interactions for drugs that exhibit pH-dependent solubility and are administered orally under hypochlorhydric conditions." | 2.79 | The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. ( Benet, LZ; Budha, N; Dean, B; Ding, X; Dresser, MJ; Frassetto, LA; Frymoyer, A; Jin, JY; Salphati, L; Smelick, GS; Ware, JA; Yago, MR, 2014) |
| "Betaine HCl was well tolerated by all subjects." | 2.78 | Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. ( Benet, LZ; Budha, NR; Dresser, MJ; Frassetto, LA; Frymoyer, AR; Smelick, GS; Ware, JA; Yago, MR, 2013) |
| "Famotidine pretreatment lowered GDC-0941 exposure by 5-fold, and decreased dasatinib measurable concentrations 30-fold, compared to the pentagastrin-treated dogs." | 1.39 | Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl. ( Dalziel, G; Dean, B; Pang, J; Salphati, L; Ware, JA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pang, J | 1 |
| Dalziel, G | 1 |
| Dean, B | 2 |
| Ware, JA | 3 |
| Salphati, L | 2 |
| Yago, MR | 3 |
| Frymoyer, AR | 1 |
| Smelick, GS | 2 |
| Frassetto, LA | 3 |
| Budha, NR | 1 |
| Dresser, MJ | 2 |
| Benet, LZ | 3 |
| Frymoyer, A | 1 |
| Ding, X | 1 |
| Budha, N | 1 |
| Jin, JY | 1 |
| Faber, KP | 1 |
| Wu, HF | 1 |
| Xu, X | 1 |
| Kadiyala, P | 1 |
| Lentini, J | 1 |
| Taure, C | 1 |
| Escala, C | 1 |
| Sharp, GS | 2 |
| Helsper, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Gastric pH on the Pharmacokinetics of Dasatinib in Healthy Volunteers[NCT01398046] | Phase 1 | 10 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for betaine and Achlorhydria
| Article | Year |
|---|---|
Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.
Topics: Achlorhydria; Adult; Anti-Ulcer Agents; Betaine; Female; Healthy Volunteers; Humans; Hydrogen-Ion Co | 2013 |
The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.
Topics: Absorption, Physiological; Achlorhydria; Adult; Antineoplastic Agents; Area Under Curve; Betaine; Cr | 2014 |
Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.
Topics: Absorption, Physiological; Achlorhydria; Administration, Oral; Adult; Atazanavir Sulfate; Betaine; C | 2017 |
4 other studies available for betaine and Achlorhydria
| Article | Year |
|---|---|
Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl.
Topics: Absorption; Achlorhydria; Animals; Antineoplastic Agents; Betaine; Dasatinib; Dogs; Famotidine; Gast | 2013 |
[Hypochylia in the aged. Its treatment with an acid combination of pepsin and vitamins].
Topics: Achlorhydria; Aged; Betaine; Citrates; Female; Humans; Hydrochloric Acid; Lactates; Male; Niacinamid | 1970 |
Oral manifestations of systemic disease. Regimen of treatment.
Topics: Achlorhydria; Betaine; Deglutition Disorders; Dietary Proteins; Disease; Drug-Related Side Effects a | 1967 |
Treatment for low tolerance to dentures: supplemental report.
Topics: Achlorhydria; Betaine; Cellulose; Dentures; Humans; Liver Extracts; Mouth, Edentulous; Pepsin A; Qua | 1967 |