betahistine and Auditory Vertigo studies

Betahistine: A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.
betahistine : An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.

Research Excerpts

Excerpt	Relevance	Reference
"Betahistine MR (48 mg once daily) is non-inferior to betaserc (24 mg twice daily) in patients with Meniere's disease or vestibular vertigo and has a comparable safety profile."	9.34	[A study of the efficacy and safety of a new modified-release betahistine formulation in the treatment of vestibular vertigo and Meniere's disease]. ( Kazei, DV; Nauta, J; Parfenov, VA; Zamergrad, MV, 2020)
" One study with a low risk of bias found no significant difference between the betahistine groups and placebo with respect to vertigo after a long-term follow-up period."	9.22	Betahistine in Ménière's Disease or Syndrome: A Systematic Review. ( Bruintjes, T; van Benthem, PP; van der Zaag-Loonen, H; Van Esch, B, 2022)
"The present study compares the efficacy and safety of betahistine dihydrochloride to that of a placebo in recurrent vertigo resulting from Meniere's disease (MD) or in paroxysmal positional vertigo (PPV) of probable vascular origin."	9.10	Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. ( Brizi, S; Fattori, B; Frasconi, P; Ghilardi, L; Guidetti, G; Leprini, M; Maiolino, L; Malannino, N; Mira, E; Mora, R; Nuti, D; Ottoboni, S; Pagnini, P; Pallestrini, E; Passali, D; Russolo, M; Simoncelli, C; Tirelli, G; Vicini, C, 2003)
"The aim of this double-blind, randomized, multicenter study was to compare the efficacy of betahistine dihydrochloride (BH) and flunarizine (FL) using the Dizziness Handicap Inventory (DHI), a validated self-assessment questionnaire that has not previously been used in a clinical trial to evaluate antivertigo drugs."	9.10	Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo. ( Albera, R; Ciuffolotti, R; De Benedittis, G; Di Cicco, M; Grazioli, I; Melzi, G; Mira, E; Pallestrini, E; Passali, D; Serra, A; Vicini, C, 2003)
"The efficacy of trimetazidine (60 mg/day) in vertigo was compared with that of betahistine (24 mg/day) in a three-month double-blind study."	9.06	[Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. ( D'Hooge, D; Kluyskens, P; Lambert, P, 1990)
"The vasodilating properties of histamine were the basis for histamine treatment of episodic vertigo and other inner ear dysfunctions."	8.78	Histamine in the treatment of vertigo. ( Fischer, AJ, 1991)
"This study aimed to assess whether standard-dose Betahistine (48 mg daily) exerts an effect upon the degree of endolymphatic hydrops in patients with Menière's disease using a retrospective case series in the setting of a tertiary neurotology referral centre."	7.79	Effect of standard-dose Betahistine on endolymphatic hydrops: an MRI pilot study. ( Ertl-Wagner, B; Flatz, W; Gürkov, R; Keeser, D; Krause, E; Strupp, M, 2013)
"A short profile of betahistine and its activity in treatment of Menière's disease and other forms of peripheral vertigo is presented."	7.71	Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches. ( Mira, E, 2001)
"Betahistine MR (48 mg once daily) is non-inferior to betaserc (24 mg twice daily) in patients with Meniere's disease or vestibular vertigo and has a comparable safety profile."	5.34	[A study of the efficacy and safety of a new modified-release betahistine formulation in the treatment of vestibular vertigo and Meniere's disease]. ( Kazei, DV; Nauta, J; Parfenov, VA; Zamergrad, MV, 2020)
"A new delirium was induced when, after discharge from the hospital, betahistine was restarted because of dizziness."	5.32	[Delirium in a 73-year-old man after many years of unwise use of betahistine]. ( Hoenders, HJ; Wilterdink, J, 2004)
" One study with a low risk of bias found no significant difference between the betahistine groups and placebo with respect to vertigo after a long-term follow-up period."	5.22	Betahistine in Ménière's Disease or Syndrome: A Systematic Review. ( Bruintjes, T; van Benthem, PP; van der Zaag-Loonen, H; Van Esch, B, 2022)
"The aim of this double-blind, randomized, multicenter study was to compare the efficacy of betahistine dihydrochloride (BH) and flunarizine (FL) using the Dizziness Handicap Inventory (DHI), a validated self-assessment questionnaire that has not previously been used in a clinical trial to evaluate antivertigo drugs."	5.10	Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo. ( Albera, R; Ciuffolotti, R; De Benedittis, G; Di Cicco, M; Grazioli, I; Melzi, G; Mira, E; Pallestrini, E; Passali, D; Serra, A; Vicini, C, 2003)
"The present study compares the efficacy and safety of betahistine dihydrochloride to that of a placebo in recurrent vertigo resulting from Meniere's disease (MD) or in paroxysmal positional vertigo (PPV) of probable vascular origin."	5.10	Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. ( Brizi, S; Fattori, B; Frasconi, P; Ghilardi, L; Guidetti, G; Leprini, M; Maiolino, L; Malannino, N; Mira, E; Mora, R; Nuti, D; Ottoboni, S; Pagnini, P; Pallestrini, E; Passali, D; Russolo, M; Simoncelli, C; Tirelli, G; Vicini, C, 2003)
"In a randomized, double-blind clinical study, we evaluated the efficacy and tolerability of the fixed combination of cinnarizine, 20 mg, and dimenhydrinate, 40 mg (Arlevert [ARL]) in comparison to betahistine dimesylate (12 mg) in 82 patients suffering from Ménière's disease for at least 3 months and showing the characteristic triad of symptoms (paroxysmal vertigo attacks, cochlear hearing loss, and tinnitus)."	5.10	Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménière's disease: a randomized, double-blind, parallel group clinical study. ( Kostrica, R; Novotný, M, 2002)
"The efficacy of trimetazidine (60 mg/day) in vertigo was compared with that of betahistine (24 mg/day) in a three-month double-blind study."	5.06	[Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. ( D'Hooge, D; Kluyskens, P; Lambert, P, 1990)
" We concluded betahistine might reduce the number of attacks, vertigo intensity and lead to a symptomatic improvement according to global judgement in patients with Menieres disease, but the certainty of evidence is low."	4.95	Is betahistine effective for Ménières disease? ( Rosenbaum, A; Winter, M, 2017)
"The unique pharmacologic properties of betahistine point to its potential future use as an antiobesity agent."	4.84	Betahistine: what's new on the agenda? ( Barak, N, 2008)
"The vasodilating properties of histamine were the basis for histamine treatment of episodic vertigo and other inner ear dysfunctions."	4.78	Histamine in the treatment of vertigo. ( Fischer, AJ, 1991)
"To elucidate the relationship between vertigo and EH volume after medical treatment, we investigated changes in endolymphatic hydrops (EH) volume using inner ear magnetic resonance imaging (ieMRI) in relation to clinical results for vertigo and hearing after administration of the anti-vertiginous medications betahistine, adenosine triphosphate (ATP), isosorbide (ISO), and saireito (SAI) for Meniere's disease (MD)."	4.31	Evaluation of changes in endolymphatic hydrops volume after medical treatments for Meniere's disease using 3D magnetic resonance imaging. ( Fujita, H; Inui, H; Kitahara, T; Sakagami, M; Ueda, K; Yamashita, A, 2023)
"Patients in the betahistine and Tetrax groups showed significant improvements in Dizziness Handicap Index and fall index scores after treatment versus before treatment (p < 0."	3.96	The benefits of betahistine or vestibular rehabilitation (Tetrax biofeedback) on the quality of life and fall risk in patients with Ménière's disease. ( Chen, XB; Liu, JG; Liu, JL; Liu, YH, 2020)
" 99%), metabolized by monoamine oxidases (MAO), the benefits of a high-dosage betahistine monotherapy were compared with those of a lower dosage of betahistine in combination with the MAO-B inhibitor (MAO-B) selegiline on the frequency of acute attacks of vertigo in patients with Menière's disease (MD)."	3.88	Menière's disease: combined pharmacotherapy with betahistine and the MAO-B inhibitor selegiline-an observational study. ( Kraus, L; Rujescu, D; Schautzer, F; Strupp, M, 2018)
"This study aimed to assess whether standard-dose Betahistine (48 mg daily) exerts an effect upon the degree of endolymphatic hydrops in patients with Menière's disease using a retrospective case series in the setting of a tertiary neurotology referral centre."	3.79	Effect of standard-dose Betahistine on endolymphatic hydrops: an MRI pilot study. ( Ertl-Wagner, B; Flatz, W; Gürkov, R; Keeser, D; Krause, E; Strupp, M, 2013)
"Betahistine is a structural analogue of histamine that is prescribed for the treatment of vestibular disorders such as Ménière's disease and the symptomatic treatment of vertigo."	3.73	Betahistine: a retrospective synopsis of safety data. ( Jeck-Thole, S; Wagner, W, 2006)
"A short profile of betahistine and its activity in treatment of Menière's disease and other forms of peripheral vertigo is presented."	3.71	Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches. ( Mira, E, 2001)
"Betahistine has not been proven to be superior to placebo in the BEMED study, a multicenter, double-blind, randomized, placebo controlled trial."	3.30	Betahistine Prescribing Practices in England: An Analysis of Prescribing and National Spending Pre- and Post-BEMED Trial. ( Ghedia, R; Harcourt, J; Sutton, L, 2023)
"Low dose betahistine increased cochlear microcirculation significantly when combined with selegiline."	3.30	Low Dose Betahistine in Combination With Selegiline Increases Cochlear Blood Flow in Guinea Pigs. ( Bertlich, M; Canis, M; Freytag, S; Ihler, F; Kloos, B; Lauer, SK; Spiegel, JL; Weiss, BG, 2023)
"Sanchi Tong Shu capsule is a safe and effective drug for the treatment of common aural vertigo."	2.77	[Clinical effectiveness and safety of sanchi tong shu capsule in the treatment of aural vertigo: a multi-center randomized controlled clinical trial]. ( Hu, G; Kong, W; Li, X; Liu, B; Liu, S; Meng, J; Yang, Y, 2012)
" In this case series 11 patients with MD who had not responded sufficiently to a dosage of 144 mg/day of betahistine dihydrochloride were treated on an individual basis with daily dosages between 288 and 480 mg of betahistine dihydrochloride."	2.76	High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series. ( Adrion, C; Jahn, K; Lezius, F; Mansmann, U; Strupp, M, 2011)
"Betahistine was effective as soon as 4 days after treatment administration, and the effect remained during the whole compensation period (up to 3 months)."	2.76	Betahistine treatment improves the recovery of static symptoms in patients with unilateral vestibular loss. ( Bernard-Demanze, L; Borel, L; Dumitrescu, M; Lacour, M; Lopez, C; Magnan, J; Redon, C, 2011)
" There was no significant difference between dosage groups regarding improvement in vertigo at any time point during the study."	2.74	Comparable efficacy and tolerability between twice daily and three times daily betahistine for Ménière's disease. ( Caovilla, HH; Ganança, FF; Ganança, MM, 2009)
"Despite the considerable limitations of an open, non-masked trial, particularly in Menière's disease (MD), a higher dosage of betahistine-dihydrochloride and a long-term treatment seems to be more effective than a low dosage and short-term treatment."	2.73	Long-term prophylactic treatment of attacks of vertigo in Menière's disease--comparison of a high with a low dosage of betahistine in an open trial. ( Brandt, T; Frenzel, C; Hahn, A; Hupert, D; Jahn, K; Mansmann, U; Strupp, M; Wagner, J; Zingler, VC, 2008)
"Betahistine is a weak agonist for histamine H1 receptors and strong antagonist for histamine H3 receptors."	2.72	[Betahistine in vestibular disorders: current concepts and perspectives]. ( Amelin, AV; Guseva, AL; Kunelskaya, NL; Lilenko, SV; Lyapin, AV; Melnikov, OA; Samartcev, IN; Voronov, VA; Zamergrad, MV; Zaytseva, OV, 2021)
"To achieve both hearing preservation and vertigo control, the best treatment option among the pharmacologic interventions compared may be IT steroid plus high-dose betahistine, considering that IT gentamicin may have good performance to control vertigo but may be detrimental to hearing preservation with high cumulative dosage and short interval between injections."	2.66	Pharmacologic and surgical therapies for patients with Meniere's disease: A systematic review and network meta-analysis. ( Ahmadzai, N; Bonaparte, J; Cheng, W; Esmaeilisaraji, L; Fitzpatrick, E; Hutton, B; Kilty, S; Lin, V; Schramm, D; Skidmore, B; Wolfe, D, 2020)
"Vertigo was the most responsive symptom."	2.64	Betahistine hydrochloride in Méniére's disease. ( Frew, IJ; Menon, GN, 1976)
"MD subjects with and without migraine demonstrated a decrease in both vertigo spells and migrainous attacks during combined therapy (from 9."	2.50	Association of cinnarizine and betahistine in prophylactic therapy for Ménière's disease with and without migraine. ( Benazzo, M; Bussi, M; Gatti, O; Quaglieri, S; Sykopetrites, V; Teggi, R, 2014)
"Dizziness is not a unique clinical picture, but rather is the unspecific symptom of numerous diseases."	2.44	[Frequently occurring forms of dizziness and their treatment]. ( Thömke, F, 2007)
"Betahistine was considered useful for the treatment of dizziness and vertigo during the intercritical phase of the disease (87% agreeing answers)."	1.48	Report from a Consensus Conference on the treatment of Ménière's disease with betahistine: rationale, methodology and results. ( Casani, AP; Guidetti, G; Schoenhuber, R, 2018)
"To describe the course of Meniere's disease with noninvasive treatment during the first few years after initial diagnosis."	1.48	Newly Diagnosed Meniere's Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine. ( Christov, F; Gluth, MB; Sbeih, F, 2018)
"Escitalopram 10 mg was prescribed to the patients."	1.46	Effects of Selective Seratonine Re-Uptake Inhibitors on Meniere's Disease. ( Kıroğlu, M; Kıroğlu, O; Sürmelioğlu, Ö, 2017)
"Betahistine is a histamine-like drug that is used in the treatment of Ménière's disease."	1.40	Betahistine metabolites, aminoethylpyridine, and hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivo. ( Bertlich, M; Canis, M; Ihler, F; Sharaf, K; Strupp, M; Weiss, BG, 2014)
" A total of 113 medical records were analysed; 53 patients received betahistine-dihydrochloride at on-label dosage (32 mg die) for six months, and 60 patients were treated with the same regimen and nimodipine (40 mg die) as an add-therapy during the same period."	1.38	Effect of a fixed combination of nimodipine and betahistine versus betahistine as monotherapy in the long-term treatment of Ménière's disease: a 10-year experience. ( Aggazzotti Cavazza, E; Alicandri Ciufelli, M; Barillari, MR; Genovese, E; Monzani, D; Neri, V; Presutti, L, 2012)
"Vertigo was caused by chronic brain ischemia in 17 cases and by the disturbance of blood circulation in the vertebral-basilar system in 14 patients with osteochondrosis of cervical spine."	1.38	[Treatment of vestibular vertigo and Ménière syndrome in outpatient clinics]. ( Boĭko, AN; Ganzhula, PA; Khozova, AA; Kostenko, EV; Lebedeva, AV; Lisenker, LN; Otcheskaia, OV; Petrova, LV; Torgovanova, EA, 2012)
"Group with classic Meniere's syndrome was treated at a dose of Betahistine of 3 x 16 mg and followed 8 weeks, while the second group was treated with Cinnarizine at a dose of 2 x 75 mg and also followed for 8 weeks."	1.38	Betahistine or Cinnarizine for treatment of Meniere's disease. ( Alajbegovic, A; Beslagic, O; Djelilovic-Vranic, J; Osmanagic, E; Sarajlic, Z; Tiric-Campara, M; Todorovic, L; Volic, A, 2012)
"Betahistine treatment added to VR was effective in increasing postural stability."	1.36	Does betahistine treatment have additional benefits to vestibular rehabilitation? ( Akyuz, A; Bilgen, C; Celebisoy, N; Eyigor, S; Gode, S; Karapolat, H; Kirazli, T; Kirazli, Y, 2010)
"A new delirium was induced when, after discharge from the hospital, betahistine was restarted because of dizziness."	1.32	[Delirium in a 73-year-old man after many years of unwise use of betahistine]. ( Hoenders, HJ; Wilterdink, J, 2004)
"Trimetazidine was found to be significantly more effective than betahistine as far as the overall evolution of the ENT disease was concerned, yielding 79% and 57% improvement rates in each group, respectively (p = 0."	1.28	[Trimetazidine versus betahistine in Ménière's disease. A double blind method]. ( De Domenico, F; Martini, A, 1990)
"The management of Meniere's disease with betahistine can be regarded as an improvement in the conservative therapy of this disorder."	1.26	[Treatment of Menière's disease with betahistine (author's transl)]. ( Kahl, S; Stupp, H, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (34.62)	18.7374
1990's	9 (6.92)	18.2507
2000's	25 (19.23)	29.6817
2010's	36 (27.69)	24.3611
2020's	15 (11.54)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Reduction of Plasma Vasopressin Level in Patients With Meniere's Disease[NCT01099046]	200 participants (Anticipated)	Interventional	2009-01-31	Recruiting
Effectiveness of Additional Protocol Exercises for Cervical Mobility and Proprioception in Vestibular Rehabilitation: a Randomized Controlled Trial[NCT02622516]	28 participants (Actual)	Interventional	2015-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Systemic pharmacological interventions for Ménière's disease. The Cochrane database of systematic reviews, 2023, 02-23, Volume: 2 Topics: Adrenal Cortex Hormones; Adult; Betahistine; Diuretics; Histamine Antagonists; Humans; Meniere Disea	2023
The pharmacological management of vertigo in Meniere disease. Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:14 Topics: Adrenal Cortex Hormones; Betahistine; Clinical Trials as Topic; Diuretics; Female; Gentamicins; Huma	2020
Current status on researches of Meniere's disease: a review. Acta oto-laryngologica, 2020, Volume: 140, Issue:10 Topics: Adrenal Cortex Hormones; Betahistine; Endolymphatic Hydrops; Endolymphatic Sac; Gentamicins; Humans;	2020
Using betahistine in the treatment of patients with Menière's disease: a meta-analysis with the current randomized-controlled evidence. Acta oto-laryngologica, 2020, Volume: 140, Issue:10 Topics: Betahistine; Histamine Agonists; Humans; Meniere Disease; Practice Guidelines as Topic; Randomized C	2020
Pharmacologic and surgical therapies for patients with Meniere's disease: A systematic review and network meta-analysis. PloS one, 2020, Volume: 15, Issue:9 Topics: Anti-Bacterial Agents; Betahistine; Gentamicins; Hearing; Humans; Meniere Disease; Steroids; Treatme	2020
Is Betahistine Effective in the Treatment of Ménière's Disease? The Laryngoscope, 2021, Volume: 131, Issue:12 Topics: Betahistine; Humans; Meniere Disease; Treatment Outcome	2021
[Betahistine in vestibular disorders: current concepts and perspectives]. Vestnik otorinolaringologii, 2021, Volume: 86, Issue:2 Topics: Benign Paroxysmal Positional Vertigo; Betahistine; Dizziness; Humans; Meniere Disease; Vestibular Di	2021
Betahistine in Ménière's Disease or Syndrome: A Systematic Review. Audiology & neuro-otology, 2022, Volume: 27, Issue:1 Topics: Betahistine; Deafness; Humans; Meniere Disease; Syndrome; Tinnitus; Vertigo	2022
Is betahistine effective for Ménières disease? Medwave, 2017, Oct-31, Volume: 17, Issue:8 Topics: Betahistine; Humans; Meniere Disease; Treatment Outcome; Vasodilator Agents; Vertigo	2017
European Position Statement on Diagnosis, and Treatment of Meniere's Disease. The journal of international advanced otology, 2018, Volume: 14, Issue:2 Topics: Anti-Bacterial Agents; Betahistine; Consensus; Conservative Treatment; Denervation; Diuretics; Endol	2018
Approach to Ménière disease management. Canadian family physician Medecin de famille canadien, 2019, Volume: 65, Issue:7 Topics: Betahistine; Diet, Sodium-Restricted; Disease Management; Diuretics; Dizziness; Female; Hearing Loss	2019
Meta-analysis of clinical studies with betahistine in Ménière's disease and vestibular vertigo. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014, Volume: 271, Issue:5 Topics: Betahistine; Double-Blind Method; Humans; Meniere Disease; Odds Ratio; Randomized Controlled Trials	2014
Meniere's disease. BMJ (Clinical research ed.), 2014, Nov-12, Volume: 349 Topics: Ablation Techniques; Adrenal Cortex Hormones; Automobile Driving; Betahistine; Diuretics; Ear, Inner	2014
Association of cinnarizine and betahistine in prophylactic therapy for Ménière's disease with and without migraine. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2014, Volume: 34, Issue:5 Topics: Betahistine; Calcium Channel Blockers; Cinnarizine; Drug Therapy, Combination; Female; Follow-Up Stu	2014
Menière's disease. BMJ clinical evidence, 2007, Mar-01, Volume: 2007 Topics: Acute Disease; Administration, Oral; Betahistine; Hearing Loss; Humans; Incidence; Meniere Disease;	2007
Medical management of Ménière's disease: a 10-year case series and review of literature. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2010, Volume: 267, Issue:9 Topics: Adrenal Cortex Hormones; Adult; Aminoglycosides; Betahistine; Caloric Tests; Combined Modality Thera	2010
Allergy and its relation to Meniere's disease. Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:5 Topics: Antigen-Antibody Complex; Antigens, CD; Betahistine; Desensitization, Immunologic; Diet; Ear, Inner;	2010
Medical and noninvasive therapy for Meniere's disease. Otolaryngologic clinics of North America, 2010, Volume: 43, Issue:5 Topics: Adrenal Cortex Hormones; Aminoglycosides; Betahistine; Diet, Sodium-Restricted; Diuretics; Hearing A	2010
Meniere's disease: an evidence based approach to assessment and management. International journal of clinical practice, 2012, Volume: 66, Issue:2 Topics: Antiemetics; Audiometry; Betahistine; Biomarkers; Catheter Ablation; Central Nervous System Agents;	2012
Menière's disease. Clinical evidence, 2003, Issue:9 Topics: Betahistine; Humans; Meniere Disease	2003
Menière's disease. Clinical evidence, 2004, Issue:11 Topics: Betahistine; Humans; Meniere Disease	2004
Meniere's disease. Clinical evidence, 2004, Issue:12 Topics: Betahistine; Humans; Meniere Disease	2004
Menière's disease. Clinical evidence, 2005, Issue:14 Topics: Betahistine; Humans; Meniere Disease	2005
[Frequently occurring forms of dizziness and their treatment]. MMW Fortschritte der Medizin, 2007, May-21, Volume: 149 Suppl 2 Topics: Amines; Anticonvulsants; Betahistine; Carbamazepine; Cyclohexanecarboxylic Acids; Diagnosis, Differe	2007
Betahistine: what's new on the agenda? Expert opinion on investigational drugs, 2008, Volume: 17, Issue:5 Topics: Animals; Betahistine; Clinical Trials as Topic; Cluster Headache; Drug Evaluation; Histamine Agonist	2008
Betahistine for Menière's disease or syndrome. The Cochrane database of systematic reviews, 2001, Issue:1 Topics: Betahistine; Humans; Meniere Disease; Outcome Assessment, Health Care; Randomized Controlled Trials	2001
[Menière's disease. Current status]. Revue de laryngologie - otologie - rhinologie, 2001, Volume: 122, Issue:3 Topics: Aged; Anti-Bacterial Agents; Betahistine; Ear, Inner; Endolymphatic Sac; Endoscopy; Gentamicins; His	2001
The clinical drug trial in Menière's disease with emphasis on the effect of betahistine SR. Acta oto-laryngologica. Supplementum, 1992, Volume: 497 Topics: Betahistine; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Meniere Disease	1992
Histamine in the treatment of vertigo. Acta oto-laryngologica. Supplementum, 1991, Volume: 479 Topics: Animals; Betahistine; Histamine; Humans; Meniere Disease; Receptors, Histamine; Vertigo	1991

Article	Year
Low Dose Betahistine in Combination With Selegiline Increases Cochlear Blood Flow in Guinea Pigs. The Annals of otology, rhinology, and laryngology, 2023, Volume: 132, Issue:5 Topics: Animals; Betahistine; Cochlea; Guinea Pigs; Meniere Disease; Selegiline	2023
Betahistine Prescribing Practices in England: An Analysis of Prescribing and National Spending Pre- and Post-BEMED Trial. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2023, 07-01, Volume: 44, Issue:6 Topics: Betahistine; Double-Blind Method; England; Humans; Meniere Disease; Retrospective Studies	2023
[A study of the efficacy and safety of a new modified-release betahistine formulation in the treatment of vestibular vertigo and Meniere's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:12 Topics: Betahistine; Double-Blind Method; Emotions; Humans; Meniere Disease; Vertigo	2020
Laryngo- rhino- otologie, 2017, Volume: 96, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Betahistine; Dose-Response Relationship, Drug; Double-Bl	2017
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial). BMJ (Clinical research ed.), 2016, Jan-21, Volume: 352 Topics: Adult; Aged; Aged, 80 and over; Betahistine; Dose-Response Relationship, Drug; Double-Blind Method;	2016
A Two-Year Randomized Trial of Interventions to Decrease Stress Hormone Vasopressin Production in Patients with Meniere's Disease-A Pilot Study. PloS one, 2016, Volume: 11, Issue:6 Topics: Adult; Aged; Betahistine; Disease Management; Drinking; Female; Follow-Up Studies; Hearing Loss; Hum	2016
Comparable efficacy and tolerability between twice daily and three times daily betahistine for Ménière's disease. Acta oto-laryngologica, 2009, Volume: 129, Issue:5 Topics: Administration, Oral; Adult; Aged; Betahistine; Drug Administration Schedule; Female; Histamine Agon	2009
[Picrotoxin in the treatment of Menière's disease]. Laryngo- rhino- otologie, 2008, Volume: 87, Issue:12 Topics: Administration, Oral; Adult; Aged; Betahistine; Female; Follow-Up Studies; Humans; Male; Meniere Dis	2008
Betahistine treatment improves the recovery of static symptoms in patients with unilateral vestibular loss. Journal of clinical pharmacology, 2011, Volume: 51, Issue:4 Topics: Betahistine; Double-Blind Method; Female; Humans; Male; Meniere Disease; Middle Aged; Nystagmus, Pat	2011
High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2011, Volume: 268, Issue:8 Topics: Administration, Oral; Aged; Aged, 80 and over; Betahistine; Dose-Response Relationship, Drug; Double	2011
Effect of transtympanic low-pressure therapy in patients with unilateral Menière's disease unresponsive to betahistine: a randomised, placebo-controlled, double-blinded, clinical trial. The Journal of laryngology and otology, 2012, Volume: 126, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Audiometry, Pure-Tone; Betahistine; Caloric Tests; Double-Blind Meth	2012
[Clinical effectiveness and safety of sanchi tong shu capsule in the treatment of aural vertigo: a multi-center randomized controlled clinical trial]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2012, Volume: 26, Issue:7 Topics: Adolescent; Adult; Betahistine; Drugs, Chinese Herbal; Female; Humans; Male; Meniere Disease; Middle	2012
Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2003, Volume: 260, Issue:2 Topics: Administration, Oral; Adult; Betahistine; Dose-Response Relationship, Drug; Double-Blind Method; Dru	2003
Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo. Acta oto-laryngologica, 2003, Volume: 123, Issue:5 Topics: Adult; Aged; Betahistine; Double-Blind Method; Drug Administration Schedule; Female; Flunarizine; Hi	2003
Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménière's disease: a randomized, double-blind, parallel group clinical study. The international tinnitus journal, 2002, Volume: 8, Issue:2 Topics: Adult; Aged; Betahistine; Cinnarizine; Dimenhydrinate; Double-Blind Method; Drug Combinations; Femal	2002
[Treatment costs of otogenic vertigo]. Medizinische Klinik (Munich, Germany : 1983), 2006, Nov-15, Volume: 101, Issue:11 Topics: Adult; Betahistine; Cinnarizine; Cost-Benefit Analysis; Decision Trees; Dimenhydrinate; Drug Combina	2006
Long-term prophylactic treatment of attacks of vertigo in Menière's disease--comparison of a high with a low dosage of betahistine in an open trial. Acta oto-laryngologica, 2008, Volume: 128, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Betahistine; Dose-Response Relationship, Drug; Drug Admi	2008
Betahistine dihydrochloride in the treatment of vertigo of peripheral vestibular origin. A double-blind placebo-controlled study. The Journal of laryngology and otology, 1984, Volume: 98, Issue:1 Topics: Activities of Daily Living; Betahistine; Clinical Trials as Topic; Double-Blind Method; Female; Huma	1984
[Long-term therapy of Ménière's disease. Comparison of the effects of betahistine dihydrochloride and hydrochlorothiazide]. Fortschritte der Medizin, 1982, Mar-11, Volume: 100, Issue:10 Topics: Audiometry, Pure-Tone; Betahistine; Clinical Trials as Topic; Double-Blind Method; Humans; Hydrochlo	1982
[Study of a programmed release preparation of betahistine mesylate in the treatment of Ménière's disease (author's transl)]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1981, Volume: 98, Issue:9 Topics: Adult; Aged; Betahistine; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Mal	1981
Betahistine in Ménière's disease. The Journal of laryngology and otology, 1976, Volume: 90, Issue:9 Topics: Adult; Audiometry; Betahistine; Clinical Trials as Topic; Deafness; Female; Humans; Male; Meniere Di	1976
Betahistine hydrochloride in Méniére's disease. Postgraduate medical journal, 1976, Volume: 52, Issue:610 Topics: Adult; Betahistine; Clinical Trials as Topic; Female; Humans; Male; Meniere Disease; Middle Aged; Py	1976
Controlled clinical trial comparing the effect of betahistine hydrochloride and prochlorperazine maleate on patients with Meniére's disease. Annals of clinical research, 1976, Volume: 8, Issue:4 Topics: Adult; Aged; Betahistine; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Drug Evaluation;	1976
The clinical drug trial in Menière's disease with emphasis on the effect of betahistine SR. Acta oto-laryngologica. Supplementum, 1992, Volume: 497 Topics: Betahistine; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Meniere Disease	1992
Betahistine dihydrochloride versus flunarizine. A double-blind study on recurrent vertigo with or without cochlear syndrome typical of Menière's disease. Acta oto-laryngologica. Supplementum, 1991, Volume: 490 Topics: Betahistine; Double-Blind Method; Female; Flunarizine; Humans; Male; Meniere Disease; Middle Aged; T	1991
A non-invasive, objective test of endolymphatic hydrops. Acta oto-laryngologica. Supplementum, 1991, Volume: 479 Topics: Adolescent; Adult; Aged; Audiometry, Evoked Response; Basilar Membrane; Betahistine; Double-Blind Me	1991
[Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1990, Volume: 107 Suppl 1 Topics: Adult; Analysis of Variance; Audiometry; Betahistine; Double-Blind Method; Female; Humans; Labyrinth	1990
[Need for rheologically active, vasoactive and metabolically active substances in the initial treatment of acute acoustic trauma]. HNO, 1986, Volume: 34, Issue:10 Topics: Adult; Betahistine; Dextrans; Drug Therapy, Combination; First Aid; Flunarizine; Hearing Loss, Noise	1986
Clinical evaluation of medical treatment for Menière's disease, using a double-blind controlled study. The American journal of otology, 1988, Volume: 9, Issue:5 Topics: Adenosine Triphosphate; Betahistine; Double-Blind Method; Female; Humans; Male; Meniere Disease; Mid	1988
[Treatment of Meniere disease with betahistine dimesilate (Aequamen)--double-blind study versus placebo (crossover)]. Laryngologie, Rhinologie, Otologie, 1985, Volume: 64, Issue:5 Topics: Adult; Aged; Audiometry, Pure-Tone; Auditory Threshold; Betahistine; Caloric Tests; Clinical Trials	1985
Méniére's disease: subjective and objective evaluation of medical treatment with betahistine HCl. Acta oto-laryngologica. Supplementum, 1972, Volume: 305 Topics: Acoustic Stimulation; Adult; Aged; Amine Oxidase (Copper-Containing); Audiometry; Betahistine; Clini	1972
A study of the efficacy of betahistine in Méniére's syndrome. Acta oto-laryngologica. Supplementum, 1972, Volume: 305 Topics: Activities of Daily Living; Amine Oxidase (Copper-Containing); Audiometry; Betahistine; Clinical Tri	1972
Ménière's disease. Archives of otolaryngology (Chicago, Ill. : 1960), 1967, Volume: 86, Issue:6 Topics: Betahistine; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Meniere Disease; Nausea; Placebos;	1967
[Evaluation of the effect of betahistine in Meniere's disease by double-blind test and multivariate analysis]. Jibi inkoka Otolaryngology, 1967, Volume: 39, Issue:11 Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Betahistine; Clinical Trials as Topic; Ethylamines;	1967
[Therapeutic results of betahistine on Meniere's disease. Multi-variable analysis of the results of the double blind test and Fisher's evaluation method]. Iryo, 1968, Volume: 22, Issue:5 Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Analysis of Variance; Betahistine; Clinical Trials a	1968
Modification of the vestibular function with betahistine HCl. The Laryngoscope, 1971, Volume: 81, Issue:6 Topics: Adult; Amine Oxidase (Copper-Containing); Betahistine; Capillary Permeability; Chlorides; Clinical T	1971

Article	Year
Evaluation of changes in endolymphatic hydrops volume after medical treatments for Meniere's disease using 3D magnetic resonance imaging. Auris, nasus, larynx, 2023, Volume: 50, Issue:5 Topics: Betahistine; Endolymphatic Hydrops; Humans; Magnetic Resonance Imaging; Meniere Disease; Retrospecti	2023
Conservative Treatment Possibilities of Ménière Disease, Involving Vertigo Diaries. Ear, nose, & throat journal, 2021, Volume: 100, Issue:7 Topics: Betahistine; Conservative Treatment; Drug Therapy, Combination; Female; Humans; Male; Medical Record	2021
The benefits of betahistine or vestibular rehabilitation (Tetrax biofeedback) on the quality of life and fall risk in patients with Ménière's disease. The Journal of laryngology and otology, 2020, Volume: 134, Issue:12 Topics: Accidental Falls; Adult; Aged; Betahistine; Biofeedback, Psychology; Case-Control Studies; Combined	2020
Effectiveness of intratympanic dexamethasone for the treatment of vertigo attacks in patients with Ménière's disease compared with betahistine pharmacotherapy. The Journal of international medical research, 2021, Volume: 49, Issue:4 Topics: Betahistine; Dexamethasone; Humans; Meniere Disease; Prospective Studies; Vertigo	2021
Effects of Selective Seratonine Re-Uptake Inhibitors on Meniere's Disease. The journal of international advanced otology, 2017, Volume: 13, Issue:2 Topics: Acetazolamide; Adult; Anxiety Disorders; Betahistine; Citalopram; Diuretics; Female; Humans; Male; M	2017
Population-Based Study on the Epidemiology of Ménière's Disease. Audiology & neuro-otology, 2017, Volume: 22, Issue:2 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Anxiety; Betahistine; Case-Control Studies; Comorbidity;	2017
Menière's disease: combined pharmacotherapy with betahistine and the MAO-B inhibitor selegiline-an observational study. Journal of neurology, 2018, Volume: 265, Issue:Suppl 1 Topics: Adult; Aged; Aged, 80 and over; Betahistine; Dose-Response Relationship, Drug; Drug Therapy, Combina	2018
Newly Diagnosed Meniere's Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine. The Annals of otology, rhinology, and laryngology, 2018, Volume: 127, Issue:5 Topics: Audiometry, Pure-Tone; Auditory Threshold; Betahistine; Dexamethasone; Drug Combinations; Female; Fo	2018
Annular Pancreas in Adult. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2018, 05-25, Volume: 71, Issue:5 Topics: Betahistine; Endoscopy, Digestive System; Female; Humans; Meniere Disease; Pancreas; Pancreatic Dise	2018
Report from a Consensus Conference on the treatment of Ménière's disease with betahistine: rationale, methodology and results. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2018, Volume: 38, Issue:5 Topics: Betahistine; Histamine Agonists; Humans; Meniere Disease; Treatment Outcome	2018
Therapeutic strategies in the treatment of Menière's disease: the Italian experience. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019, Volume: 276, Issue:7 Topics: Betahistine; Cross-Cultural Comparison; Diet, Sodium-Restricted; Gentamicins; Glucocorticoids; Human	2019
Patient Perceptions of Effectiveness in Treatments for Menière's Disease: a National Survey in Italy. The journal of international advanced otology, 2019, Volume: 15, Issue:1 Topics: Absenteeism; Anti-Bacterial Agents; Betahistine; Cross-Sectional Studies; Diet Therapy; Diuretics; F	2019
Betahistine or Cinnarizine for treatment of Meniere's disease. Medical archives (Sarajevo, Bosnia and Herzegovina), 2012, Volume: 66, Issue:6 Topics: Adult; Betahistine; Cinnarizine; Female; Histamine Agonists; Histamine H1 Antagonists; Humans; Male;	2012
Menière-like syndrome in Camurati-Engelmann disease. The Israel Medical Association journal : IMAJ, 2013, Volume: 15, Issue:7 Topics: Adult; Betahistine; Camurati-Engelmann Syndrome; Diet, Sodium-Restricted; Electronystagmography; Fem	2013
Betahistine metabolites, aminoethylpyridine, and hydroxyethylpyridine increase cochlear blood flow in guinea pigs in vivo. International journal of audiology, 2014, Volume: 53, Issue:10 Topics: Acetates; Animals; Betahistine; Blood Pressure; Cochlea; Guinea Pigs; Histamine Agonists; Meniere Di	2014
Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016, Volume: 273, Issue:7 Topics: Betahistine; Endolymphatic Sac; Epithelium; Histamine Agonists; Humans; Immunohistochemistry; Ion Tr	2016
Betahistine for Meniere's disease. BMJ (Clinical research ed.), 2016, Jan-21, Volume: 352 Topics: Betahistine; Humans; Meniere Disease; Vasodilator Agents	2016
Disability in patients with Menière's disease following the use of two different treatment modalities: betahistine and intratympanic gentamicin. Revue de laryngologie - otologie - rhinologie, 2008, Volume: 129, Issue:4-5 Topics: Administration, Oral; Administration, Topical; Betahistine; Disability Evaluation; Ear, Middle; Gent	2008
Does betahistine treatment have additional benefits to vestibular rehabilitation? European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2010, Volume: 267, Issue:8 Topics: Adult; Aged; Betahistine; Caloric Tests; Combined Modality Therapy; Disability Evaluation; Dose-Resp	2010
Topical application of betahistine improves eustachian tube function in an animal model. Acta oto-laryngologica, 2011, Volume: 131, Issue:11 Topics: Administration, Topical; Animals; Barotrauma; Betahistine; Drug Evaluation, Preclinical; Eustachian	2011
Effect of standard-dose Betahistine on endolymphatic hydrops: an MRI pilot study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2013, Volume: 270, Issue:4 Topics: Adult; Aged; Audiometry, Pure-Tone; Betahistine; Cohort Studies; Contrast Media; Dose-Response Relat	2013
Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: an example from a vertigo phase III study with longitudinal count data as primary endpoint. BMC medical research methodology, 2012, Sep-10, Volume: 12 Topics: Bayes Theorem; Betahistine; Clinical Trials as Topic; Data Interpretation, Statistical; Decision Sup	2012
Effect of a fixed combination of nimodipine and betahistine versus betahistine as monotherapy in the long-term treatment of Ménière's disease: a 10-year experience. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2012, Volume: 32, Issue:6 Topics: Adult; Betahistine; Drug Therapy, Combination; Female; Humans; Male; Meniere Disease; Middle Aged; N	2012
[Treatment of vestibular vertigo and Ménière syndrome in outpatient clinics]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:12 Topics: Adult; Aged; Ambulatory Care Facilities; Betahistine; Combined Modality Therapy; Exercise; Female; H	2012
[Delirium in a 73-year-old man after many years of unwise use of betahistine]. Nederlands tijdschrift voor geneeskunde, 2004, Nov-20, Volume: 148, Issue:47 Topics: Aged; Betahistine; Blood-Brain Barrier; Cerebral Infarction; Delirium; Haloperidol; Histamine Agonis	2004
A national survey amongst UK otolaryngologists regarding the treatment of Ménière's disease. The Journal of laryngology and otology, 2005, Volume: 119, Issue:2 Topics: Anti-Bacterial Agents; Betahistine; Clinical Protocols; Consultants; Diuretics; Gentamicins; Health	2005
[Vertigo attacks -- current therapy]. Laryngo- rhino- otologie, 2005, Volume: 84, Issue:11 Topics: Acetazolamide; Adult; Aged; Betahistine; Dexamethasone; Ear, Middle; Gentamicins; Humans; Injections	2005
Betahistine: a retrospective synopsis of safety data. Drug safety, 2006, Volume: 29, Issue:11 Topics: Adverse Drug Reaction Reporting Systems; Betahistine; Drug Interactions; Humans; Meniere Disease; Pr	2006
Management of Ménière's disease in general practice: adherence to the UK National Health Service 'Prodigy' guidelines. The Journal of laryngology and otology, 2008, Volume: 122, Issue:8 Topics: Adult; Betahistine; Cyclizine; England; Family Practice; Female; Guideline Adherence; Health Care Su	2008
Prescribing practices for Betahistine. British journal of clinical pharmacology, 2008, Volume: 65, Issue:4 Topics: Betahistine; Female; Histamine Agonists; Humans; Male; Meniere Disease; Treatment Outcome	2008
Betahistine hydrochloride (serc) for Meniere's syndrome. The Medical letter on drugs and therapeutics, 1967, Apr-21, Volume: 9, Issue:8 Topics: Betahistine; Enzyme Therapy; Humans; Meniere Disease	1967
Complications of treatment of peripheral vertigo. Ear, nose, & throat journal, 1984, Volume: 63, Issue:11 Topics: Aminoglycosides; Anti-Anxiety Agents; Antiemetics; Betahistine; Diuretics; Humans; Meniere Disease;	1984
[Therapy of peripheral vestibular vertigo with betahistine dimesilate (Aequamen)]. MMW, Munchener medizinische Wochenschrift, 1983, Oct-14, Volume: 125, Issue:41 Topics: Betahistine; Humans; Meniere Disease; Pyridines	1983
The treatment of peripheral dizziness. Ear, nose, & throat journal, 1984, Volume: 63, Issue:11 Topics: Antiemetics; Betahistine; Dizziness; Endolymphatic Sac; Humans; Labyrinth Diseases; Meniere Disease;	1984
Long-term evaluation of the treatment of Menière's disease with betahistine HCl. Advances in oto-rhino-laryngology, 1982, Volume: 28 Topics: Audiometry; Betahistine; Double-Blind Method; Female; Humans; Male; Meniere Disease; Pyridines; Rand	1982
Drug treatment of vertigo and Ménière's disease. Cinnarizine and betahistine. Drug and therapeutics bulletin, 1981, Feb-27, Volume: 19, Issue:5 Topics: Betahistine; Cinnarizine; Humans; Meniere Disease; Piperazines; Pyridines; Vertigo	1981
[Treatment of Menière's disease in general practice]. Fortschritte der Medizin, 1980, Nov-20, Volume: 98, Issue:43 Topics: Adult; Aged; Betahistine; Drug Evaluation; Female; Hearing Loss; Humans; Male; Meniere Disease; Midd	1980
[The effects of betahistine on the function of equilibrium system]. Otolaryngologia polska = The Polish otolaryngology, 1997, Volume: 51 Suppl 25 Topics: Adult; Aged; Betahistine; Female; Histamine Agonists; Humans; Male; Meniere Disease; Middle Aged; Pi	1997
[The use of betaserk in patients with cochlear-vestibular disorders]. Vestnik otorinolaringologii, 1998, Issue:5 Topics: Aged; Betahistine; Cochlear Diseases; Histamine Agonists; Humans; Meniere Disease; Vestibular Diseas	1998
Medical treatment in Ménière's disease: avoiding vestibular neurectomy and facilitating postoperative compensation. Acta oto-laryngologica. Supplementum, 2000, Volume: 544 Topics: Acetazolamide; Adult; Betahistine; Cinnarizine; Diuretics; Female; Histamine Agonists; Histamine H1	2000
Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2001, Volume: 21, Issue:3 Suppl 66 Topics: Betahistine; History, 20th Century; Meniere Disease; Research; Vasodilator Agents; Vertigo	2001
[Drug information. Therapeutic main group: agents for the treatment of dizziness--betahistine]. Sygeplejersken, 1979, Mar-21, Volume: 79, Issue:12 Topics: Betahistine; Humans; Meniere Disease; Pyridines; Vertigo	1979
[Drug information. Therapeutic main group: agents for the treatment of vertigo. Behahistine (Betaserc)]. Sygeplejersken, 1979, Apr-04, Volume: 79, Issue:14 Topics: Betahistine; Humans; Meniere Disease; Pyridines; Vertigo	1979
[Management of Meniere's disease using betahistine]. Die Medizinische Welt, 1978, Dec-01, Volume: 29, Issue:48 Topics: Adult; Aged; Betahistine; Chemical Phenomena; Chemistry; Female; Humans; Male; Meniere Disease; Midd	1978
[Betahistine treatment of Menière's disease (author's transl)]. Laryngologie, Rhinologie, Otologie, 1978, Volume: 57, Issue:11 Topics: Betahistine; Deafness; Drug Evaluation; Female; Humans; Male; Meniere Disease; Pyridines; Tinnitus;	1978
[Drug information. Therapy in Ménière's disease, with special reference to the use of betahistine, Betaserc]. Ugeskrift for laeger, 1978, Nov-27, Volume: 140, Issue:48 Topics: Betahistine; Humans; Meniere Disease; Pyridines	1978
[Treatment of Menière's disease with betahistine (author's transl)]. HNO, 1976, Volume: 24, Issue:9 Topics: Audiometry; Betahistine; Drug Evaluation; Humans; Meniere Disease; Pyridines; Time Factors	1976
[Medical treatment in Menière's disease (author's transl)]. Archives of oto-rhino-laryngology, 1976, Sep-16, Volume: 212, Issue:4 Topics: Anesthetics, Local; Anti-Bacterial Agents; Betahistine; Blood Viscosity; Carbon Dioxide; Diuretics;	1976
[Therapy of vertigo]. Nederlands tijdschrift voor geneeskunde, 1975, Jan-04, Volume: 119, Issue:1 Topics: Betahistine; Humans; Meniere Disease; Surveys and Questionnaires; Thiethylperazine; Vertigo	1975
Diseases of the central nervous system. Cerebral atherosclerosis, transient ischaemic attacks, Menière's disease, and disorders of balance. British medical journal, 1975, Nov-15, Volume: 4, Issue:5993 Topics: Accident Proneness; Anticoagulants; Betahistine; Brain Damage, Chronic; Cerebrovascular Circulation;	1975
Clinical trials of betahistine hydrochloride in the treatment of Ménière's disease. Acta oto-rhino-laryngologica Belgica, 1975, Volume: 29, Issue:5 Topics: Betahistine; Drug Evaluation; Hearing Disorders; Humans; Meniere Disease; Pyridines; Tinnitus	1975
[Therapeutic considerations of Meniere's disease]. Annali di laringologia, otologia, rinologia, faringologia, 1975, Volume: 74, Issue:5 Topics: Betahistine; Humans; Meniere Disease; Pyridines	1975
Treatment of acute vestibular vertigo. Acta oto-laryngologica. Supplementum, 1991, Volume: 479 Topics: Acute Disease; Betahistine; Humans; Meniere Disease; Vertigo	1991
[Trimetazidine versus betahistine in Ménière's disease. A double blind method]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1990, Volume: 107 Suppl 1 Topics: Adolescent; Adult; Aged; Audiometry; Betahistine; Double-Blind Method; Female; Humans; Male; Meniere	1990
[Treatment of Meniere's disease: conservative or operative]. Laryngologie, Rhinologie, Otologie, 1985, Volume: 64, Issue:12 Topics: Betahistine; Diuretics; Ear, Inner; Ear, Middle; Endolymphatic Sac; Gentamicins; Humans; Meniere Dis	1985
"How should a treatment of Méniére's syndrome be evaluated?" Panel discussion. Acta oto-laryngologica. Supplementum, 1972, Volume: 305 Topics: Betahistine; Female; Hearing Tests; Humans; Meniere Disease; MMPI	1972
The effect of betahistine hydrochloride in Méniére's disease. Acta oto-laryngologica. Supplementum, 1972, Volume: 305 Topics: Amine Oxidase (Copper-Containing); Audiometry; Betahistine; Ethylamines; Eye Movements; Hearing Test	1972
Otogenic vertigo--an occupational hazard. Industrial medicine & surgery, 1967, Volume: 36, Issue:11 Topics: Betahistine; Humans; Meniere Disease; Occupational Medicine; Vertigo	1967
[Initial findings in the treatment of Meniere's disease with betahistine hydrochloride (Betaserc)]. Acta oto-rhino-laryngologica Belgica, 1972, Volume: 26, Issue:2 Topics: Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Humans; Meniere Disease; Pyridines	1972
An agent for the amelioration of vertigo in Ménière's syndrome. Betahistine hydrochloride (Serc). JAMA, 1968, Mar-25, Volume: 203, Issue:13 Topics: Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Meniere Disease; Pyridines; Vertigo	1968
Long-term office treatment of Meniere's disease. Eye, ear, nose & throat monthly, 1969, Volume: 48, Issue:7 Topics: Aged; Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Female; Humans; Male; Meniere Dis	1969
Long-tm treatment of Ménière's disease. International surgery, 1970, Volume: 53, Issue:1 Topics: Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Follow-Up Studies; Humans; Hydrochloric	1970
[Treatment of endolymphatic edema with betahistine hydrochloride]. Acta oto-rino-laringologica ibero-americana, 1970, Volume: 21, Issue:3 Topics: Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Humans; Meniere Disease; Pyridines	1970
An objective study of the effect of betahistine hydrochloride on hearing and vestibular function tests in patients with Ménière's disease. The Journal of laryngology and otology, 1971, Volume: 85, Issue:4 Topics: Acceleration; Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Hearing Tests; Humans; Me	1971
Vasodilators in menière's syndrome. British medical journal, 1971, Oct-30, Volume: 4, Issue:5782 Topics: Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Female; Humans; Meniere Disease; Middle	1971
Vasodilators in Menière's syndrome. British medical journal, 1971, Nov-13, Volume: 4, Issue:5784 Topics: Amine Oxidase (Copper-Containing); Betahistine; Ethylamines; Humans; Male; Meniere Disease; Middle A	1971

betahistine and Auditory Vertigo

Research Excerpts

Research

Studies (130)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Kloos, B	1
Bertlich, M	2
Spiegel, JL	1
Freytag, S	1
Lauer, SK	1
Canis, M	2
Weiss, BG	2
Ihler, F	2
Webster, KE	1
Galbraith, K	1
Harrington-Benton, NA	1
Judd, O	1
Kaski, D	1
Maarsingh, OR	1
MacKeith, S	1
Ray, J	1
Van Vugt, VA	1
Burton, MJ	2
Yamashita, A	2
Kitahara, T	2
Sakagami, M	2
Ueda, K	1
Fujita, H	1
Inui, H	1
Sutton, L	1
Ghedia, R	1
Harcourt, J	3
Molnár, A	2
Maihoub, S	2
Tamás, L	2
Szirmai, Á	2
Espinosa-Sanchez, JM	1
Lopez-Escamez, JA	1
Liu, Y	1
Yang, J	1
Duan, M	1
Devantier, L	1
Hougaard, D	1
Händel, MN	1
Liviu-Adelin Guldfred, F	1
Schmidt, JH	1
Djurhuus, B	1
Callesen, HE	1
Ahmadzai, N	1
Cheng, W	1
Kilty, S	1
Esmaeilisaraji, L	1
Wolfe, D	1
Bonaparte, J	1
Schramm, D	1
Fitzpatrick, E	1
Lin, V	1
Skidmore, B	1
Hutton, B	1
Liu, JL	1
Liu, JG	1
Chen, XB	1
Liu, YH	1
Parfenov, VA	1
Zamergrad, MV	2
Kazei, DV	1
Nauta, J	1
Holmes, S	1
Lalwani, AK	1
Mankekar, G	1
Kunelskaya, NL	1
Guseva, AL	1
Amelin, AV	1
Lilenko, SV	1
Samartcev, IN	1
Zaytseva, OV	1
Melnikov, OA	1
Voronov, VA	1
Lyapin, AV	1
Van Esch, B	1
van der Zaag-Loonen, H	1
Bruintjes, T	1
van Benthem, PP	1
Kıroğlu, O	1
Sürmelioğlu, Ö	1
Kıroğlu, M	1
Bruderer, SG	1
Bodmer, D	1
Stohler, NA	1
Jick, SS	1
Meier, CR	1
Ernst, A	1
Schlattmann, P	1
Waldfahrer, F	1
Westhofen, M	1
Rosenbaum, A	1
Winter, M	1
Strupp, M	6
Kraus, L	1
Schautzer, F	1
Rujescu, D	1
Sbeih, F	1
Christov, F	1
Gluth, MB	1
Kim, SB	1
Kim, KH	1
Kim, TN	1
Magnan, J	2
Özgirgin, ON	1
Trabalzini, F	2
Lacour, M	2
Escamez, AL	1
Magnusson, M	1
Güneri, EA	1
Guyot, JP	1
Nuti, D	3
Mandalà, M	2
Casani, AP	1
Guidetti, G	2
Schoenhuber, R	1
Quaranta, N	1
Picciotti, P	1
Porro, G	1
Sterlicchio, B	1
Danesi, G	1
Petrone, P	1
Asprella Libonati, G	1
Ward, B	1
Wettstein, V	1
Golding, J	1
Corallo, G	1
Wu, V	1
Sykes, EA	1
Beyea, MM	1
Simpson, MTW	1
Beyea, JA	1
Djelilovic-Vranic, J	1
Alajbegovic, A	1
Tiric-Campara, M	1
Volic, A	1
Sarajlic, Z	1
Osmanagic, E	1
Todorovic, L	1
Beslagic, O	1
Nauta, JJ	1
Pollak, L	1
Sharaf, K	1
Barraclough, K	1
Bronstein, AM	1
Teggi, R	1
Gatti, O	1
Sykopetrites, V	1
Quaglieri, S	1
Benazzo, M	1
Bussi, M	1
Møller, MN	1
Kirkeby, S	1
Vikeså, J	1
Nielsen, FC	1
Caye-Thomasen, P	1
Cosentino, S	1
Adrion, C	3
Fischer, CS	1
Wagner, J	2
Gürkov, R	3
Mansmann, U	4
Okamoto, H	1
Fukushima, M	1
Ito, T	1
Ota, I	1
Yamanaka, T	1
Ganança, MM	1
Caovilla, HH	1
Ganança, FF	1
Weikert, S	1
Rotter, A	1
Scherer, H	3
Hölzl, M	1
Enrique-Gonzaleza, A	1
Sánchez-Ferrándiz, N	1
Pérez-Fernández, N	1
James, AL	2
Thorp, MA	1
Martín González, C	1
González, FM	1
Trinidad, A	1
Ibáñez, A	1
Pinilla, M	1
Martínez Ruiz-Coello, A	1
Rodríguez Valiente, A	1
López-Cortijo, C	1
Karapolat, H	1
Celebisoy, N	1
Kirazli, Y	1
Bilgen, C	1
Eyigor, S	1
Gode, S	1
Akyuz, A	1
Kirazli, T	1
Derebery, MJ	1
Berliner, KI	1
Greenberg, SL	1
Nedzelski, JM	1
Redon, C	1
Lopez, C	1
Bernard-Demanze, L	1
Dumitrescu, M	1
Borel, L	1
Lezius, F	1
Jahn, K	2
Franz, B	1
Shafton, AD	1
Anderson, CR	1
Syed, I	1
Aldren, C	1
Filipe Mingas, LB	1
Rader, T	1
Louza, J	1
Olzowy, B	1
Krause, E	2
Meng, J	1
Liu, B	1
Li, X	1
Yang, Y	1
Liu, S	1
Kong, W	1
Hu, G	1
Flatz, W	1
Keeser, D	1
Ertl-Wagner, B	1
Monzani, D	1
Barillari, MR	1
Alicandri Ciufelli, M	1
Aggazzotti Cavazza, E	1
Neri, V	1
Presutti, L	1
Genovese, E	1
Kostenko, EV	1
Petrova, LV	1
Torgovanova, EA	1
Ganzhula, PA	1
Lisenker, LN	1
Otcheskaia, OV	1
Khozova, AA	1
Lebedeva, AV	1
Boĭko, AN	1
Mira, E	3
Ghilardi, L	1
Fattori, B	1
Malannino, N	1
Maiolino, L	1
Mora, R	1
Ottoboni, S	1
Pagnini, P	1
Leprini, M	1
Pallestrini, E	2
Passali, D	2
Russolo, M	1
Tirelli, G	1
Simoncelli, C	1
Brizi, S	1
Vicini, C	2
Frasconi, P	1
Albera, R	1
Ciuffolotti, R	1
Di Cicco, M	1
De Benedittis, G	1
Grazioli, I	1
Melzi, G	1
Serra, A	1
James, A	4
Thorp, M	4
Novotný, M	1
Kostrica, R	1
Hoenders, HJ	1
Wilterdink, J	1
Smith, WK	1
Sankar, V	1
Pfleiderer, AG	1
Helling, K	1
Jeck-Thole, S	1
Wagner, W	1
Stratmann, L	1
Heinen-Kammerer, T	1
Motzkat-Gniss, K	1
Holtmannspötter, C	1
Rychlik, R	1
Thömke, F	1
Smale, E	1
McDonald, S	1
Maha, N	1
Short, S	1
Phillips, JS	1
Prinsley, PR	1
Hupert, D	1
Frenzel, C	1
Hahn, A	1
Zingler, VC	1
Brandt, T	1
Barak, N	1
Harris, T	1
Oosterveld, WJ	2
Reker, U	1
Curley, JW	1
Petermann, W	1
Mulch, G	1
Pialoux, P	1
Bertrand, RA	3
Bandtlow, O	1
Kubiczkowa, J	1
Kadymov, MI	1
Poliakova, TS	1
Vladimirova, TN	1
Colletti, V	1
Darrouzet, V	1
Bouccara, D	1
Bozorg Grayeli, A	1
Couloigner, V	1
Negrevergne, M	1
Sterkers, O	1
Lumholtz, IB	2
Chüden, HG	2
Pedersen, CB	1
Kampmann, JP	1
Wilmot, TJ	3
Menon, GN	2
Frew, IJ	1
Aantaa, E	2
Skinhoj, A	1
Stupp, H	2
Kahl, S	1
Hood, NA	1
Segers, JM	2
Boedts, D	1
Romeo, A	1
Schmidt, JT	1
Huizing, EH	1
Fraysse, B	1
Bebear, JP	1
Dubreuil, C	1
Berges, C	1
Dauman, R	1
Fischer, AJ	1
Thornton, AR	1
Farrell, G	1
Haacke, NP	1
Kluyskens, P	1
Lambert, P	1
D'Hooge, D	1
Martini, A	1
De Domenico, F	1
Pilgramm, M	1
Schumann, K	1
Mizukoshi, K	1
Watanabe, I	1
Matsunaga, T	2
Hinoki, M	1
Komatsuzaki, A	1
Takayasu, S	1
Tokita, T	1
Matsuoka, I	1
Tanaka, T	1
Meyer, ED	1
Beck, C	1
Arnold, W	1
Lange, G	1
Rudert, H	1
Hommes, OR	1
Elia, JC	1
Hicks, JJ	1
Hicks, JN	1
Cooley, HN	1
Watanabe, K	1
Fukami, J	1
Yoshimoto, H	1
Ueda, M	1
Suzuki, J	1
Okamoto, K	1
Hazeyama, F	1
Taira, T	1
Yoshida, A	1
Onoda, T	1
Martins, JK	1
Elia, J	1
Bosch, J	1
Piercy, NM	1
Tuke, JU	1