betadex and Sexually-Transmitted-Diseases

betadex has been researched along with Sexually-Transmitted-Diseases* in 1 studies

Other Studies

1 other study(ies) available for betadex and Sexually-Transmitted-Diseases

Article	Year
Phase solubility studies and anti-Trichomonas vaginalis activity evaluations of metronidazole and methylated β-cyclodextrin complexes: Comparison of CRYSMEB and RAMEB. Experimental parasitology, 2018, Volume: 189 Metronidazole (MTZ) is a 5-nitroimidazole drug used for the treatment of Trichomonas vaginalis parasitic infection. Aqueous formulations containing MTZ are restricted because apparent solubility in water of this drug is low. In this context, two methylated-β-cyclodextrins (CRYSMEB and RAMEB) were used as a tool to increase apparent solubility of MTZ in water. CRYSMEB was limited by its own solubility in water (15% w/w, 12.59 mM), while RAMEB at a concentration of 40% w/w (300.44 mM) allowed a maximal increase of apparent solubility of MTZ (3.426% w/w, 200.19 mM). From our knowledge, this corresponds to the highest enhancement of MTZ apparent aqueous solubility ever reported in the literature using methylated cyclodextrins. In vitro evaluations showed that anti-T. vaginalis activity of MTZ formulated with CRYSMEB and RAMEB was preserved. Topics: Antiprotozoal Agents; beta-Cyclodextrins; Calibration; Chromatography, High Pressure Liquid; Crystallization; Female; Humans; Methylation; Metronidazole; Sexually Transmitted Diseases; Solubility; Trichomonas vaginalis; Trichomonas Vaginitis	2018

Article

Year

Phase solubility studies and anti-Trichomonas vaginalis activity evaluations of metronidazole and methylated β-cyclodextrin complexes: Comparison of CRYSMEB and RAMEB.

Experimental parasitology, 2018, Volume: 189

Metronidazole (MTZ) is a 5-nitroimidazole drug used for the treatment of Trichomonas vaginalis parasitic infection. Aqueous formulations containing MTZ are restricted because apparent solubility in water of this drug is low. In this context, two methylated-β-cyclodextrins (CRYSMEB and RAMEB) were used as a tool to increase apparent solubility of MTZ in water. CRYSMEB was limited by its own solubility in water (15% w/w, 12.59 mM), while RAMEB at a concentration of 40% w/w (300.44 mM) allowed a maximal increase of apparent solubility of MTZ (3.426% w/w, 200.19 mM). From our knowledge, this corresponds to the highest enhancement of MTZ apparent aqueous solubility ever reported in the literature using methylated cyclodextrins. In vitro evaluations showed that anti-T. vaginalis activity of MTZ formulated with CRYSMEB and RAMEB was preserved.

Topics: Antiprotozoal Agents; beta-Cyclodextrins; Calibration; Chromatography, High Pressure Liquid; Crystallization; Female; Humans; Methylation; Metronidazole; Sexually Transmitted Diseases; Solubility; Trichomonas vaginalis; Trichomonas Vaginitis

2018