betadex has been researched along with Fissure-in-Ano* in 1 studies
1 other study(ies) available for betadex and Fissure-in-Ano
Article | Year |
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Modified-release ointment with nitroglycerin β-cyclodextrin inclusion complex for treatment of anal fissures.
The aim was to evaluate ointments for local treatment of anal fissures. Nitroglycerin (NTG) was complexed with β-cyclodextrin (β-CD) to provide prolonged NTG release, with the intention of decreasing systemic drug absorption and thus reducing side effects.. Gels, creams and anhydrous water-emulsifying (AWE) ointment with NTG-CD were compared with preparations containing uncomplexed NTG (diluted with crospovidone, NTG-cP). The in-vitro NTG release and ex-vivo skin absorption were studied.. The prolonged-release ointment with the NTG-CD complex was formulated using AWE base or w/o cream (20% water); release of NTG from a hydrogel was very fast with both the complexed and uncomplexed forms. From the AWE ointment base, 16.4% or 4.5% of the total NTG dose was released after 6 h when NTG-cP or NTG-CD was incorporated, respectively. With the complexed form, NTG absorption to the skin after a 5-h application was 18.1 or 11.1 μg/g from AWE ointment or cream, respectively; absorption of the uncomplexed NTG was higher: 52.3 or 21.9 μg/g from AWE ointment and cream, respectively.. Complexation with β-CD results in prolonged release of NTG from AWE ointment and w/o cream, which was confirmed by the ex-vivo skin absorption results. Topics: Adult; beta-Cyclodextrins; Cadaver; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Female; Fissure in Ano; Humans; Hydrogels; In Vitro Techniques; Nitroglycerin; Ointments; Skin; Skin Absorption; Solubility | 2013 |