beta-naphthoflavone has been researched along with Acute Liver Injury, Drug-Induced in 10 studies
beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308)
beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple doses of beta-naphthoflavone to iron-loaded C57BL/10ScSn mice for 6 weeks caused inhibition of hepatic uroporphyrinogen decarboxylase and a porphyria indistinguishable from that previously only reported for polyhalogenated aromatic chemicals." | 3.67 | Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. ( Francis, JE; Smith, AG, 1987) |
| " Pretreatment with Aroclor 1254 or beta-naphthoflavone (beta-NF) did not alter the LD50 of 1-NN." | 1.29 | 1-Nitronaphthalene toxicity in rat lung and liver: effects of inhibiting and inducing cytochrome P450 activity. ( Carthew, P; Dinsdale, D; Verschoyle, RD; Wolf, CR, 1993) |
| "Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice." | 1.29 | Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993) |
| "Coumarin (200 mg/kg) was hepatotoxic to both strains, resulting in 2- to 15-fold plasma aminotransferase elevations, mild subcapsular linear hepatocyte necrosis after 24 hr, and, in some C3H/He mice, centrilobular necrosis." | 1.29 | Strain-specific enhancement or inhibition of coumarin hepatotoxicity in mice following pretreatment with two different liver enzyme-inducing agents. ( Cottrell, S; Lake, BG; Oliver, K; Powell, CJ, 1996) |
| " The activities of NADPH-cytochrome P-450 reductase, AHH, and ECOD following treatment with HCB were similar to those found after dosing with PB." | 1.27 | A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. ( Buhler, DR; Carpenter, HM; Williams, DE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donald, S | 1 |
| Verschoyle, RD | 2 |
| Greaves, P | 1 |
| Orr, S | 1 |
| Jimeno, J | 1 |
| Gescher, AJ | 1 |
| Carthew, P | 1 |
| Wolf, CR | 1 |
| Dinsdale, D | 1 |
| Jaw, S | 1 |
| Jeffery, EH | 1 |
| Gadberry, MG | 1 |
| DeNicola, DB | 1 |
| Carlson, GP | 1 |
| Cottrell, S | 1 |
| Oliver, K | 1 |
| Lake, BG | 1 |
| Powell, CJ | 1 |
| Mizutani, T | 1 |
| Satoh, K | 1 |
| Nomura, H | 1 |
| Nakanishi, K | 1 |
| Sequeira, S | 1 |
| So, PW | 1 |
| Everett, JR | 1 |
| Elcombe, CR | 1 |
| Kelvin, AS | 1 |
| Nicholson, JK | 1 |
| Yoshikawa, T | 1 |
| Ruhr, LP | 1 |
| Flory, W | 1 |
| Banton, MI | 1 |
| Giamalva, D | 1 |
| Church, DF | 1 |
| Pryor, WA | 1 |
| Francis, JE | 1 |
| Smith, AG | 1 |
| Carpenter, HM | 1 |
| Williams, DE | 1 |
| Buhler, DR | 1 |
10 other studies available for beta-naphthoflavone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotra | 2004 |
1-Nitronaphthalene toxicity in rat lung and liver: effects of inhibiting and inducing cytochrome P450 activity.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chemical and Drug Induced Liver Injury; Chlor | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav | 1993 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; C | 1996 |
Strain-specific enhancement or inhibition of coumarin hepatotoxicity in mice following pretreatment with two different liver enzyme-inducing agents.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; beta-Naphthoflavone; Chemical | 1996 |
Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine.
Topics: Alanine Transaminase; Animals; Antimetabolites; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfo | 1991 |
1H-NMR spectroscopy of biofluids and the investigation of xenobiotic-induced changes in liver biochemistry.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Fluids; Chemical and Drug Induced Liver Injury; Ga | 1990 |
Toxicity of polycyclic aromatic hydrocarbons. III. Effects of beta-naphthoflavone pretreatment on hepatotoxicity of compounds produced in the ozonation or NO2-nitration of phenanthrene and pyrene in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chemical and Drug Induced Liver Injury; Flavonoids; L-L | 1987 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Che | 1987 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Ch | 1985 |