beta-n-methylamino-l-alanine and ALS - Amyotrophic Lateral Sclerosis

beta-n-methylamino-l-alanine has been researched along with ALS - Amyotrophic Lateral Sclerosis in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (7.04)	18.7374
1990's	6 (8.45)	18.2507
2000's	23 (32.39)	29.6817
2010's	33 (46.48)	24.3611
2020's	4 (5.63)	2.80

Authors

Authors	Studies
Angelis, G; Pampalakis, G; Sotiropoulou, G; Vekrellis, K; Zingkou, E	1
Brooks, J; Burton, B; Collins, K; Marx, K; Moore, E; Osowski, K; Pawlus, M; Renner, A; Riley, J; Rowe, J; Wilcox, K	1
Banack, SA; Cox, PA; Green, AJ; Howell, S; Metcalf, JS; Planchart, A; Thunga, P; Weeks, RD	1
Banack, SA; Beierschmitt, A; Bradley, WG; Cox, PA; Davis, DA; Garamszegi, SP; Hagan, MJ; Lecusay, PD; Mash, DC; Metcalf, JS; Palmour, RM; Powell, JT	1
Banack, SA; Cox, PA	2
Bradley, W; Facciponte, D; Michaelson, N; Stommel, E	1
Cox, PA; Guillemin, GJ; Kostrzewa, RM	1
Chernoff, N; Diggs, DL; Faison, BD; Francis, BM; Hill, DJ; Lang, JR; Larue, MM; Le, TT; Loftin, KA; Lugo, JN; Schmid, JE; Winnik, WM	1
Banack, SA; Cox, PA; Kokubo, Y; Kuzuhara, S; Metcalf, JS; Morimoto, S; Murayama, S; Togashi, T	1
Bereman, MS; Beri, J; Martin, RM; Nash, T	1
Nunn, PB	2
Cai, HY; Han, S; Jiang, H; Tian, KW; Zhang, YY	1
Dokholyan, NV; Mowrey, DD; Proctor, EA	1
Banack, SA; Caller, TA; Cox, PA; Field, NC; Metcalf, JS; Stommel, EW	1
Arahuetes, RM; de Munck, E; Gil, C; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Ojeda, I; Solas, MT	1
Basile, M; Mash, DC; Xie, X	1
Boumediene, F; Couratier, P; Delzor, A; Marin, B; Preux, PM	1
Kisby, GE; Moore, H; Spencer, PS	1
Eriksson, J; Ilag, LL; Jiang, L; Jonasson, S; Lage, S; Mehine, M; Rasmussen, U; Shams, S	1
Camu, W; Corcia, P; Juntas-Morales, R; Pageot, N	1
Combes, A; El Abdellaoui, S; Lagrange, E; Pichon, V; Vial, J	1
Acab, A; Chiang, BJ; Hsu, CI; Liu, J; Tao, A; Weiss, JH; Wu, R; Yin, HZ; Yu, S	1
Banack, SA; Bradley, WG; Cox, PA; Metcalf, JS	1
Abadie, E; Besson, G; Bicout, DJ; Bonneterre, V; Boumédiène, F; Boutonnat, J; Brient, L; Camu, W; Combès, A; Couratier, P; Delzor, A; Druet-Cabanac, M; El Abdellaoui, S; Juntas-Morales, R; Lagrange, E; Leleu, JP; Lengronne, M; Marin, B; Masseret, E; Méjean, A; Nicol, M; Pageot, N; Paraf, F; Pichon, V; Ploux, O; Preux, PM; Rigau, V	1
Banack, SA; Caller, T; Cox, PA; Haney, J; Henegan, P; Metcalf, JS; Murby, A; Powell, J; Stommel, E	1
Bergman, B; Berntzon, L; Eriksson, J; Ronnevi, LO	1
Buscail, C; Dupas, R; Grimaldi, C; Serrano, T; Upegui, E; Viel, JF	1
Arahuetes, RM; de Munck, E; Martínez, A; Miguel, BG; Muñoz-Sáez, E; Solas, MT	1
Banack, SA; Cox, PA; Davis, DA; Mash, DC; Metcalf, JS	1
Kwok, S; Lavin, T; Lovejoy, E; Powers, S; Sher, RB	1
Cui, AM; Davenport, B; Garruto, RM; Go, RC; Heizer, JW; Hermosura, MC; Mocz, G; Perraud, AL; Schmitz, C; Shetler, CM	1
Banack, SA; Bradley, WG; Cox, PA	1
Cruz-Aguado, R; Shaw, CA	1
Kisby, G; Palmer, V; Spencer, PS	1
Banack, SA; Bradley, WG; Buck, A; Cox, PA; Johnson, TE; Mash, DC; Pablo, J; Papapetropoulos, S	1
Liu, X; Lobner, D; Rush, T; Zapata, J	1
Barceloux, DG	1
Bradley, WG; Mash, DC	1
Ball, A; Caller, TA; Doolin, JW; Farrar, HE; Haney, JF; Harris, BT; Murby, AJ; Stommel, EW; West, KG	1
Banack, SA; Caller, TA; Stommel, EW	1
Caller, TA; Chipman, JW; Field, NC; Harris, BT; Shi, X; Stommel, EW	1
Deschl, U; Dietrich, DR; Okle, O; Stemmer, K	1
Brenner, SR	1
Caller, TA; Field, NC; Stommel, EW	1
Guseo, A	1
Borenstein, AR; Bradley, WG; Codd, GA; Cox, PA; Nelson, LM; Rosen, BH; Stommel, EW	1
Armon, C	1
Banack, SA; Cox, PA; Murch, SJ	1
Banack, SA; Cox, PA; Murch, SJ; Sacks, OW; Steele, JC	1
Galasko, D; Li, K; Montine, TJ; Perl, DP	1
Banack, SA; Cox, PA; Rao, SD; Weiss, JH	1
Miller, G	1
Arnetoli, G; Barsanti, L; Biondi, N; de Scisciolo, G; Lolli, F; Stipa, G; Taiuti, R; Tredici, MR	1
Duncan, MW; Marini, AM	1
Banack, S; Cox, PA; Murch, S; Sacks, O	1
Kuzuhara, S	1
Karamyan, VT; Speth, RC	1
Hugon, J; Kisby, GE; Ludolph, AC; Nunn, PB; Ross, SM; Roy, DN; Spencer, PS	1
Cox, PA; Sacks, OW	1
Mannen, T	1
Duncan, MW	2
Choi, DW; Weiss, JH	1
Duncan, MW; Kopin, IJ; Markey, SP; Steele, JC	1
Kurland, LT	1
Hugon, J; Ludolph, A; Nunn, PB; Roy, DN; Spencer, PS	1
Gilks, CF	1
Gajdusek, DC; Garruto, RM; Yanagihara, R	1
Hugon, J; Ludolph, AC; Nunn, PB; Robertson, RC; Ross, SM; Roy, DN; Spencer, PS	1

Reviews

15 review(s) available for beta-n-methylamino-l-alanine and ALS - Amyotrophic Lateral Sclerosis

Article	Year
A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis. Clinical and translational medicine, 2022, Volume: 12, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Cycas; Disease Models, Animal; Mice	2022
BMAA and Neurodegenerative Illness. Neurotoxicity research, 2018, Volume: 33, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Excitatory Amino Acid Agonists; Humans; Parkinsonian Disorders	2018
A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans. Journal of toxicology and environmental health. Part B, Critical reviews, 2017, Volume: 20, Issue:4 Topics: Alzheimer Disease; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria; Cyanobacteria Toxins; Cycas; Flour; Humans; Neurodegenerative Diseases; Neurotoxins; Parkinsonian Disorders	2017
Animal models of brain maldevelopment induced by cycad plant genotoxins. Birth defects research. Part C, Embryo today : reviews, 2013, Volume: 99, Issue:4 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain; Cyanobacteria Toxins; Cycas; Disease Models, Animal; DNA Damage; Humans; Mutagens; Neurotoxins	2013
Cycad seeds and chronic neurologic disease (Cycas species). Disease-a-month : DM, 2009, Volume: 55, Issue:6 Topics: Alzheimer Disease; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System Diseases; Chronic Disease; Cyanobacteria Toxins; Cycas; Foodborne Diseases; Humans; Neurotoxins; Parkinson Disease; Plant Poisoning; Seeds	2009
The cyanobacteria derived toxin Beta-N-methylamino-L-alanine and amyotrophic lateral sclerosis. Toxins, 2010, Volume: 2, Issue:12 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Bacterial Toxins; Brain; Cyanobacteria; Cyanobacteria Toxins; Environmental Exposure; Guam; Humans	2010
Spatial clustering of amyotrophic lateral sclerosis and the potential role of BMAA. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2012, Volume: 13, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cluster Analysis; Cyanobacteria; Cyanobacteria Toxins; Environment; Epidemiologic Studies; Excitatory Amino Acid Agonists; Humans; Neurotoxins; Risk Factors	2012
[The Parkinson puzzle]. Orvosi hetilap, 2012, Dec-30, Volume: 153, Issue:52 Topics: alpha-Synuclein; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chiroptera; Cyanobacteria Toxins; Dementia; Depression; Depressive Disorder; Duodenal Ulcer; Encephalitis; Excitatory Amino Acid Agonists; Feces; Helicobacter Infections; Helicobacter pylori; Humans; Intestines; Lewy Bodies; Oxidative Stress; Parkinson Disease; Sleep Initiation and Maintenance Disorders; Stomach Ulcer	2012
Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases? Amyotrophic lateral sclerosis & frontotemporal degeneration, 2013, Volume: 14, Issue:5-6 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria; Cyanobacteria Toxins; Environmental Exposure; Gene-Environment Interaction; Humans; Neurodegenerative Diseases; Neurotoxins; Risk Factors	2013
[Revisit to Kii ALS--the innovated concept of ALS-Parkinsonism-dementia complex, clinicopathological features, epidemiology and etiology]. Brain and nerve = Shinkei kenkyu no shinpo, 2007, Volume: 59, Issue:10 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Brain; Cyanobacteria Toxins; Dementia; DNA-Binding Proteins; Humans; Japan; Minerals; Morbidity; Mutation; Parkinsonian Disorders; Superoxide Dismutase; Superoxide Dismutase-1; tau Proteins	2007
Animal models of BMAA neurotoxicity: a critical review. Life sciences, 2008, Jan-30, Volume: 82, Issue:5-6 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain; Cyanobacteria Toxins; Disease Models, Animal; Environmental Exposure; Excitatory Amino Acid Antagonists; Food Chain; Food Contamination; Guam; Meat; Neurotoxins; Parkinson Disease, Secondary; Plants, Edible	2008
Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology, 2002, Mar-26, Volume: 58, Issue:6 Topics: Alzheimer Disease; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chiroptera; Cyanobacteria Toxins; Cycas; Cycasin; Diet; Female; Guam; Humans; Incidence; Male; Native Hawaiian or Other Pacific Islander; Parkinson Disease; Parkinson Disease, Secondary; Plants, Toxic; Seeds	2002
[Amyotrophic lateral sclerosis--its problem]. No to shinkei = Brain and nerve, 1992, Volume: 44, Issue:6 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Autoimmune Diseases; Cyanobacteria Toxins; Humans; N-Methylaspartate	1992
beta-Methylamino-L-alanine (BMAA) and amyotrophic lateral sclerosis-parkinsonism dementia of the western Pacific. Annals of the New York Academy of Sciences, 1992, May-11, Volume: 648 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria Toxins; Diet; Guam; Humans; Neurotoxins; Parkinson Disease, Secondary; Risk Factors	1992
Amyotrophic lateral sclerosis and Parkinson's disease complex on Guam linked to an environmental neurotoxin. Trends in neurosciences, 1988, Volume: 11, Issue:2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria Toxins; Guam; Humans; Neurotoxins; Parkinson Disease, Secondary; Plant Poisoning	1988

Other Studies

56 other study(ies) available for beta-n-methylamino-l-alanine and ALS - Amyotrophic Lateral Sclerosis

Article	Year
The biotoxin BMAA promotes dysfunction via distinct mechanisms in neuroblastoma and glioblastoma cells. PloS one, 2023, Volume: 18, Issue:3 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Glioblastoma; Humans; Neuroblastoma; Neurotoxins; Parkinsonian Disorders	2023
The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD Neurotoxicity research, 2023, Volume: 41, Issue:5 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Neurodegenerative Diseases; Neurotoxins; Superoxide Dismutase; Zebrafish	2023
l-Serine Reduces Spinal Cord Pathology in a Vervet Model of Preclinical ALS/MND. Journal of neuropathology and experimental neurology, 2020, 04-01, Volume: 79, Issue:4 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chlorocebus aethiops; Cyanobacteria Toxins; Disease Models, Animal; Male; Microglia; Motor Neuron Disease; Motor Neurons; Pyramidal Tracts; Serine; Spinal Cord	2020
Creating a Simian Model of Guam ALS/PDC Which Reflects Chamorro Lifetime BMAA Exposures. Neurotoxicity research, 2018, Volume: 33, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain; Chlorocebus aethiops; Cyanobacteria Toxins; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Guam; Humans; Male; Neurofibrillary Tangles; Parkinsonian Disorders; Plaque, Amyloid	2018
Cytokine expression levels in ALS: A potential link between inflammation and BMAA-triggered protein misfolding. Cytokine & growth factor reviews, 2017, Volume: 37 Topics: Adaptive Immunity; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Cytokines; Gene Expression; Humans; Immunity, Innate; Inflammasomes; Inflammation; Mice; Neuroimmunomodulation; NLR Family, Pyrin Domain-Containing 3 Protein; Proteostasis Deficiencies	2017
β-N-methylamino-l-alanine analysis in the brains of patients with Kii ALS/PDC. Neurology, 2017, 09-05, Volume: 89, Issue:10 Topics: Aged; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Brain; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Dementia; Female; Humans; Japan; Male; Mass Spectrometry; Middle Aged; Parkinsonian Disorders	2017
Exposure to BMAA mirrors molecular processes linked to neurodegenerative disease. Proteomics, 2017, Volume: 17, Issue:17-18 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cyanobacteria Toxins; Diet; Excitatory Amino Acid Agonists; Gene Expression Regulation; Mice; Motor Neurons; Neuroblastoma	2017
50 years of research on α-amino-β-methylaminopropionic acid (β-methylaminoalanine). Phytochemistry, 2017, Volume: 144 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Cycas; Dementia; Guam; Humans; Molecular Structure; Parkinsonian Disorders; Seeds	2017
Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model. Aging, 2018, 11-25, Volume: 10, Issue:11 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Angiopoietin-1; Animals; Cyanobacteria Toxins; Gene Expression Regulation; Integrin alpha Chains; Male; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley	2018
β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology. PLoS computational biology, 2019, Volume: 15, Issue:7 Topics: Amino Acid Substitution; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Binding Sites; Computational Biology; Cyanobacteria Toxins; Enzyme Stability; Humans; Molecular Dynamics Simulation; Protein Aggregation, Pathological; Protein Folding; Protein Modification, Translational; Protein Structure, Quaternary; Superoxide Dismutase-1	2019
Linking β-methylamino-L-alanine exposure to sporadic amyotrophic lateral sclerosis in Annapolis, MD. Toxicon : official journal of the International Society on Toxinology, 2013, Volume: 70 Topics: Aged; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Bacterial Toxins; Brachyura; Chromatography, Liquid; Cyanobacteria; Cyanobacteria Toxins; Environmental Exposure; Female; Humans; Male; Maryland; Middle Aged; Neurotoxins; Risk Factors; Surveys and Questionnaires; Tandem Mass Spectrometry	2013
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS. Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 3; Choline; Creatinine; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Endoplasmic Reticulum; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Magnetic Resonance Spectroscopy; Male; Mitochondria; Motor Activity; Motor Cortex; Nerve Degeneration; Neurologic Examination; Phenotype; Rats; Rats, Wistar; Spinal Cord; Time Factors	2013
Cerebral uptake and protein incorporation of cyanobacterial toxin β-N-methylamino-L-alanine. Neuroreport, 2013, Oct-02, Volume: 24, Issue:14 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Bacterial Toxins; Brain; Cyanobacteria Toxins; Dementia; Disease Models, Animal; Half-Life; Marine Toxins; Mice; Microcystins; Neurotoxins	2013
BMAALS: a French national project searching for a link between amyotrophic lateral sclerosis and the neurotoxic amino acid L-BMAA. Amyotrophic lateral sclerosis & frontotemporal degeneration, 2014, Volume: 15, Issue:1-2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria Toxins; Female; France; Humans; Male; Neurotoxicity Syndromes; Retrospective Studies	2014
Diatoms: a novel source for the neurotoxin BMAA in aquatic environments. PloS one, 2014, Volume: 9, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Diatoms; Environmental Exposure; Environmental Monitoring; Neurotoxins; Sweden; Tandem Mass Spectrometry	2014
[Environmental factors in ALS]. Presse medicale (Paris, France : 1983), 2014, Volume: 43, Issue:5 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria Toxins; Environment; Humans	2014
Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-L-alanine in brain tissues. Analytical and bioanalytical chemistry, 2014, Volume: 406, Issue:19 Topics: Amino Acids, Diamino; Aminobutyrates; Amyotrophic Lateral Sclerosis; Animals; Cattle; Chromatography, Reverse-Phase; Cyanobacteria Toxins; Hippocampus; Humans; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry	2014
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Experimental neurology, 2014, Volume: 261 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Survival; Cyanobacteria Toxins; Disease Models, Animal; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Glutamate Plasma Membrane Transport Proteins; Humans; Male; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Tyrosine	2014
Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida. Toxicon : official journal of the International Society on Toxinology, 2014, Volume: 90 Topics: Adult; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria; Cyanobacteria Toxins; Florida; Humans; Limit of Detection; Male; Middle Aged; Neurotoxins; Shellfish; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme. BMJ open, 2014, Sep-01, Volume: 4, Issue:8 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Brain; Brain Chemistry; Case-Control Studies; Cluster Analysis; Cyanobacteria Toxins; Drinking Water; Environmental Exposure; Food Analysis; France; Humans; Leisure Activities; Neurotoxins; Occupational Exposure; Occupations; Registries	2014
Detection of cyanotoxins, β-N-methylamino-L-alanine and microcystins, from a lake surrounded by cases of amyotrophic lateral sclerosis. Toxins, 2015, Jan-29, Volume: 7, Issue:2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain; Carps; Chromatography, Liquid; Cyanobacteria; Cyanobacteria Toxins; Environmental Monitoring; Eutrophication; Food Chain; Humans; Lakes; Limit of Detection; Liver; Microcystins; Muscle, Skeletal; New Hampshire; Tandem Mass Spectrometry; Water Pollutants, Chemical	2015
Detection of BMAA in the human central nervous system. Neuroscience, 2015, Apr-30, Volume: 292 Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Female; Humans; Male; Middle Aged; Oceans and Seas; Sweden; Tandem Mass Spectrometry; Young Adult	2015
Geographical modeling of exposure risk to cyanobacteria for epidemiological purposes. Environment international, 2015, Volume: 81 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria; Cyanobacteria Toxins; Environmental Exposure; Environmental Monitoring; Epidemiologic Studies; Eutrophication; France; Geographic Information Systems; Humans; Models, Theoretical; Phosphorus; Risk Factors	2015
Morphometric and neurochemical alterations found in l-BMAA treated rats. Environmental toxicology and pharmacology, 2015, Volume: 39, Issue:3 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria; Cyanobacteria Toxins; Diatoms; Disease Models, Animal; Humans; Male; Motor Cortex; Muscle, Skeletal; Neurotoxins; Rats	2015
Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain. Proceedings. Biological sciences, 2016, Jan-27, Volume: 283, Issue:1823 Topics: Amino Acids, Diamino; Amyloid beta-Peptides; Amyotrophic Lateral Sclerosis; Animals; Brain; Chlorocebus aethiops; Cyanobacteria Toxins; Food Contamination; Guam; Humans; Neurofibrillary Tangles; Plant Roots; Population Groups; Serine	2016
Editor's Highlight: Embryonic Exposure to the Environmental Neurotoxin BMAA Negatively Impacts Early Neuronal Development and Progression of Neurodegeneration in the Sod1-G93R Zebrafish Model of Amyotrophic Lateral Sclerosis. Toxicological sciences : an official journal of the Society of Toxicology, 2017, 05-01, Volume: 157, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cyanobacteria Toxins; Disease Models, Animal; Disease Progression; Environmental Exposure; Genotype; Neurotoxins; Superoxide Dismutase-1; Zebrafish	2017
Altered functional properties of a TRPM2 variant in Guamanian ALS and PD. Proceedings of the National Academy of Sciences of the United States of America, 2008, Nov-18, Volume: 105, Issue:46 Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Calcium; Calcium Signaling; Cell Membrane; Conserved Sequence; Cyanobacteria Toxins; Evolution, Molecular; Guam; Humans; Hydrogen Peroxide; Ion Channel Gating; Leucine; Magnesium; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Mutation; Oxidative Stress; Parkinsonian Disorders; Proline; Temperature; TRPM Cation Channels	2008
The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology, 2009, Feb-03, Volume: 72, Issue:5 Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Bacterial Toxins; Brain; Causality; Cyanobacteria Toxins; Cycas; Dementia; Flour; Guam; Hazardous Substances; Humans; Marine Toxins; Microcystins; Parkinsonian Disorders; Plant Extracts; Syndrome	2009
The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology, 2009, Feb-03, Volume: 72, Issue:5 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Bacterial Toxins; Causality; Cyanobacteria Toxins; Cycas; Data Interpretation, Statistical; Dementia; Epidemiologic Research Design; Epidemiologic Studies; Flour; Guam; Hazardous Substances; Humans; Incidence; Marine Toxins; Microcystins; Parkinsonian Disorders; Plant Extracts; Sex Distribution; Syndrome	2009
The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology, 2009, Feb-03, Volume: 72, Issue:5 Topics: alpha-Synuclein; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Bacterial Toxins; Causality; Cyanobacteria Toxins; Cycas; Dementia; Disease Models, Animal; Epidemiologic Research Design; Epidemiologic Studies; Flour; Guam; Hazardous Substances; Humans; Incidence; Indonesia; Japan; Marine Toxins; Methylazoxymethanol Acetate; Microcystins; Nerve Degeneration; Parkinsonian Disorders; Plant Extracts; Syndrome; Tauopathies	2009
Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease. Acta neurologica Scandinavica, 2009, Volume: 120, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Female; Humans; Huntington Disease; Male; Mass Spectrometry; Middle Aged; Postmortem Changes; Retrospective Studies	2009
beta-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc(-). Experimental neurology, 2009, Volume: 217, Issue:2 Topics: Amino Acid Transport System y+; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Central Nervous System; Coculture Techniques; Cyanobacteria Toxins; Cystine; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glutathione; Mice; Neurodegenerative Diseases; Neurons; Neurotoxins; Oxidative Stress; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate	2009
Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2009, Volume: 10 Suppl 2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Bacterial Toxins; Cyanobacteria; Cyanobacteria Toxins; Ecosystem; Guam; Humans; Marine Toxins; Microcystins; Neurodegenerative Diseases	2009
Three phases of research on beta-N-methylamino-L-alanine (BMAA)--a neurotoxic amino acid. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2009, Volume: 10 Suppl 2 Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Biomedical Research; Blood-Brain Barrier; Cyanobacteria Toxins; Disease Models, Animal; Humans; Neurotoxicity Syndromes; Neurotoxins; Primates; Rats	2009
A cluster of amyotrophic lateral sclerosis in New Hampshire: a possible role for toxic cyanobacteria blooms. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2009, Volume: 10 Suppl 2 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Chromatography, High Pressure Liquid; Cluster Analysis; Cyanobacteria; Cyanobacteria Toxins; Ecosystem; Eukaryota; Humans; Incidence; New Hampshire; Phycocyanin; Retrospective Studies; Tandem Mass Spectrometry; Water Microbiology	2009
L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 131, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Caspase 12; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cyanobacteria Toxins; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Excitatory Amino Acid Agonists; Guam; HEK293 Cells; Humans; Parkinson Disease; Protein Binding; Protein Folding; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Supranuclear Palsy, Progressive; Ubiquitinated Proteins	2013
Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-L-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson-Dementia-Complex in Medical hypotheses, 2013, Volume: 80, Issue:1 Topics: Alzheimer Disease; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria; Cyanobacteria Toxins; Horse Diseases; Horses; Humans; Metagenome; Models, Biological; Motor Neuron Disease; Neurotoxins; Parkinson Disease; Supranuclear Palsy, Progressive	2013
Aerosolization of cyanobacteria as a risk factor for amyotrophic lateral sclerosis. Medical hypotheses, 2013, Volume: 80, Issue:2 Topics: Aerosols; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Bacterial Toxins; Cyanobacteria; Cyanobacteria Toxins; Humans; Models, Biological	2013
Western Pacific ALS/PDC and flying foxes: What's next? Neurology, 2003, Aug-12, Volume: 61, Issue:3 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chiroptera; Cyanobacteria Toxins; Cycasin; Food Chain; Guam; Humans; Indonesia; Japan; Parkinson Disease; Pollen	2003
Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam. Neurology, 2003, Aug-12, Volume: 61, Issue:3 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Chiroptera; Cyanobacteria Toxins; Cycas; Food Chain; Guam; Humans; Parkinson Disease; Seeds; Skin	2003
Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-11, Volume: 100, Issue:23 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain; Chiroptera; Cyanobacteria; Cyanobacteria Toxins; Cycas; Dementia; Ecosystem; Food Chain; Guam; Humans; Neurodegenerative Diseases; Neurotoxins; Parkinson Disease; Plant Roots; Plants, Edible	2003
Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam. Acta neurologica Scandinavica, 2004, Volume: 110, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Bacterial Toxins; Case-Control Studies; Cyanobacteria Toxins; Dementia; Female; Frontal Lobe; Guam; Humans; Male; Marine Toxins; Microcystins; Middle Aged; Neurotoxins; Parkinsonian Disorders	2004
Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC. Neurology, 2005, Sep-13, Volume: 65, Issue:5 Topics: Aged; Alzheimer Disease; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Brain; Brain Chemistry; Canada; Cyanobacteria Toxins; Environmental Exposure; Female; Guam; Humans; Male; Middle Aged; Parkinsonian Disorders; Reproducibility of Results	2005
BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Experimental neurology, 2006, Volume: 201, Issue:1 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Calcium; Cell Survival; Cells, Cultured; Cyanobacteria Toxins; Cycas; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Mice; Motor Neurons; Neurotoxins; Plant Extracts; Plant Poisoning; Quinoxalines; Reactive Oxygen Species; Receptors, AMPA; Receptors, Kainic Acid; Seeds; Spinal Cord	2006
Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide? Science (New York, N.Y.), 2006, Jul-28, Volume: 313, Issue:5786 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain Chemistry; Chiroptera; Cyanobacteria; Cyanobacteria Toxins; Cycadopsida; Diet; Ethnicity; Food Chain; Guam; Humans; Models, Animal; Neurodegenerative Diseases; Neurotoxins; Parkinsonian Disorders; Seeds; Water Supply	2006
Sporadic amyotrophic lateral sclerosis as an infectious disease: a possible role of cyanobacteria? Medical hypotheses, 2006, Volume: 67, Issue:6 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Communicable Diseases; Cyanobacteria; Cyanobacteria Toxins; Humans; Incidence; Models, Biological; Population Groups	2006
Debating the cause of a neurological disorder. Science (New York, N.Y.), 2006, Sep-22, Volume: 313, Issue:5794 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Brain Chemistry; Chiroptera; Cyanobacteria Toxins; Cycadopsida; Diet; Guam; Humans; Neurodegenerative Diseases; Neurotoxins	2006
Commentary on: Return of the cycad hypothesis--does the amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? Neuropathology and applied neurobiology, 2006, Volume: 32, Issue:6 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Bacterial Toxins; Cyanobacteria; Cyanobacteria Toxins; Cycas; Diet; Excitatory Amino Acid Agonists; Guam; Humans; Marine Toxins; Microcystins; Parkinsonian Disorders	2006
Guam ALS-PDC: possible causes. Science (New York, N.Y.), 1993, Nov-05, Volume: 262, Issue:5135 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Cycasin; Dementia; Guam; Humans; Macaca; Methylazoxymethanol Acetate; Neurotoxins; Parkinson Disease; Plants, Toxic; Syndrome	1993
Slow non-NMDA receptor mediated neurotoxicity and amyotrophic lateral sclerosis. Advances in neurology, 1991, Volume: 56 Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Humans; Neurotoxins; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Time Factors	1991
Role of the cycad neurotoxin BMAA in the amyotrophic lateral sclerosis-parkinsonism dementia complex of the western Pacific. Advances in neurology, 1991, Volume: 56 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Biological Transport; Blood-Brain Barrier; Cells, Cultured; Chromatography, Gas; Cyanobacteria Toxins; Dementia; Flour; Humans; Mass Spectrometry; Neurons; Neurotoxins; Pacific Islands; Parkinson Disease, Secondary; Plants, Toxic; Seeds; Syndrome	1991
2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Neurology, 1990, Volume: 40, Issue:5 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria Toxins; Flour; Guam; Humans; Neurotoxins; Parkinson Disease, Secondary; Plants, Edible; Seeds; Statistics as Topic	1990
Motorneurone disease on Guam: possible role of a food neurotoxin. Lancet (London, England), 1986, Apr-26, Volume: 1, Issue:8487 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Food Analysis; Guam; Humans; Macaca fascicularis; Male; Neurotoxins; Seeds	1986
Cycads and sago. Lancet (London, England), 1988, Jan-23, Volume: 1, Issue:8578 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Cyanobacteria Toxins; Dementia; Humans; Neurotoxins; Parkinson Disease; Plants, Edible	1988
Cycads and amyotrophic lateral sclerosis/parkinsonism dementia. Lancet (London, England), 1988, Nov-05, Volume: 2, Issue:8619 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Dementia; Disease Models, Animal; Female; Humans; Macaca fascicularis; Parkinson Disease, Secondary; Seeds	1988
Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science (New York, N.Y.), 1987, Jul-31, Volume: 237, Issue:4814 Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Basal Ganglia Diseases; Cyanobacteria Toxins; Environmental Exposure; Guam; Macaca fascicularis; Male; Motor Cortex; Motor Neurons; Neural Conduction; Neuromuscular Diseases; Neurotoxins; Plants, Toxic; Spinal Cord; Substantia Nigra	1987