beta-lapachone has been researched along with Retinoblastoma in 2 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the cytotoxicity of beta-lapachone, a potent agent that may selectively target tumour cells, in retinoblastoma (RB) cell lines." | 7.74 | Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines. ( Conway, RM; Howard, SA; Madigan, MC; O'Brien, JM; Qi, J; Shah, HR; Van Quill, KR; Weinberg, V, 2008) |
| "Treatment with wortmannin or transfection with a dominant negative form of Akt anticipated at 24 h the effects induced by PTX/LPC, suggesting a protective role against apoptosis played by Akt in Y79 cells." | 5.36 | Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. ( Augello, G; D'Anneo, A; di Fiore, R; Giuliano, M; Messina, C; Santulli, A; Tesoriere, G; Vento, R, 2010) |
| "To investigate the cytotoxicity of beta-lapachone, a potent agent that may selectively target tumour cells, in retinoblastoma (RB) cell lines." | 3.74 | Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines. ( Conway, RM; Howard, SA; Madigan, MC; O'Brien, JM; Qi, J; Shah, HR; Van Quill, KR; Weinberg, V, 2008) |
| "Treatment with wortmannin or transfection with a dominant negative form of Akt anticipated at 24 h the effects induced by PTX/LPC, suggesting a protective role against apoptosis played by Akt in Y79 cells." | 1.36 | Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. ( Augello, G; D'Anneo, A; di Fiore, R; Giuliano, M; Messina, C; Santulli, A; Tesoriere, G; Vento, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| D'Anneo, A | 1 |
| Augello, G | 1 |
| Santulli, A | 1 |
| Giuliano, M | 1 |
| di Fiore, R | 1 |
| Messina, C | 1 |
| Tesoriere, G | 1 |
| Vento, R | 1 |
| Shah, HR | 1 |
| Conway, RM | 1 |
| Van Quill, KR | 1 |
| Madigan, MC | 1 |
| Howard, SA | 1 |
| Qi, J | 1 |
| Weinberg, V | 1 |
| O'Brien, JM | 1 |
2 other studies available for beta-lapachone and Retinoblastoma
| Article | Year |
|---|---|
Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.
Topics: Active Transport, Cell Nucleus; Androstadienes; Antineoplastic Agents, Phytogenic; Antineoplastic Co | 2010 |
Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Induct | 2008 |