beta-lapachone has been researched along with Ovarian Neoplasms in 4 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, betulinic acid, a novel chemotherapeutic compound, induced apoptosis and KILLER/DR5 mRNA in melanoma and glioblastoma cells through a p53-independent mechanism." | 3.71 | p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. ( El-Deiry, WS; Meng, RD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, M | 1 |
| Chang, W | 1 |
| Zhang, K | 1 |
| Cui, M | 1 |
| Wu, S | 1 |
| Xu, T | 1 |
| Li, CJ | 1 |
| Li, YZ | 1 |
| Pinto, AV | 1 |
| Pardee, AB | 1 |
| Meng, RD | 1 |
| El-Deiry, WS | 1 |
| Katz, EJ | 1 |
| Vick, JS | 1 |
| Kling, KM | 1 |
| Andrews, PA | 1 |
| Howell, SB | 1 |
4 other studies available for beta-lapachone and Ovarian Neoplasms
| Article | Year |
|---|---|
Expression and purification of recombinant ATF-mellitin, a new type fusion protein targeting ovarian cancer cells, in P. pastoris.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Gene Expression; | 2016 |
Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Cyclin-Dependent Kinases; Drug | 1999 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Topics: Antibiotics, Antineoplastic; Apoptosis; Betulinic Acid; Colonic Neoplasms; Dactinomycin; Dexamethaso | 2001 |
Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cells.
Topics: Antibiotics, Antineoplastic; Camptothecin; Cell Line; Cisplatin; DNA Topoisomerases, Type I; Drug In | 1990 |