beta-lapachone has been researched along with Muscular Atrophy, Spinal in 1 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Camptothecin treatment reduced the DNA relaxation activity of DNA topoisomerase I in human fibroblasts." | 1.35 | Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent. ( Funanage, VL; Gómez-Curet, I; Scavina, M; Wang, W; Wu, CY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, CY | 1 |
| Gómez-Curet, I | 1 |
| Funanage, VL | 1 |
| Scavina, M | 1 |
| Wang, W | 1 |
1 other study available for beta-lapachone and Muscular Atrophy, Spinal
| Article | Year |
|---|---|
Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent.
Topics: Apoptosis; Camptothecin; Cells, Cultured; DNA Topoisomerases, Type I; Fibroblasts; Humans; Muscular | 2009 |