beta-lapachone has been researched along with Multiple Myeloma in 2 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the anti-tumor potential of beta-lapachone in multiple myeloma (MM) cell lines (U266, RPMI8226, and MM." | 7.71 | beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells. ( Akiyama, M; Anderson, KC; Catley, L; Chauhan, D; Gupta, D; Hideshima, T; LeBlanc, R; Lin, B; Mitsiades, C; Mitsiades, N; Munshi, NC; Podar, K; Tai, YT, 2002) |
| "Human multiple myeloma (MM) remains an incurable hematological malignancy." | 5.31 | Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells. ( Li, CJ; Li, Y; Pardee, AB; Yu, D, 2000) |
| "To evaluate the anti-tumor potential of beta-lapachone in multiple myeloma (MM) cell lines (U266, RPMI8226, and MM." | 3.71 | beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells. ( Akiyama, M; Anderson, KC; Catley, L; Chauhan, D; Gupta, D; Hideshima, T; LeBlanc, R; Lin, B; Mitsiades, C; Mitsiades, N; Munshi, NC; Podar, K; Tai, YT, 2002) |
| "Human multiple myeloma (MM) remains an incurable hematological malignancy." | 1.31 | Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells. ( Li, CJ; Li, Y; Pardee, AB; Yu, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, D | 1 |
| Podar, K | 1 |
| Tai, YT | 1 |
| Lin, B | 1 |
| Hideshima, T | 1 |
| Akiyama, M | 1 |
| LeBlanc, R | 1 |
| Catley, L | 1 |
| Mitsiades, N | 1 |
| Mitsiades, C | 1 |
| Chauhan, D | 1 |
| Munshi, NC | 1 |
| Anderson, KC | 1 |
| Li, Y | 1 |
| Li, CJ | 1 |
| Yu, D | 1 |
| Pardee, AB | 1 |
2 other studies available for beta-lapachone and Multiple Myeloma
| Article | Year |
|---|---|
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Bone Marrow Cells; Caspas | 2002 |
Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Blotting, Western; Cell Division; Cell Survival; Cytochrome | 2000 |