beta-lapachone has been researched along with Melanoma in 4 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, betulinic acid, a novel chemotherapeutic compound, induced apoptosis and KILLER/DR5 mRNA in melanoma and glioblastoma cells through a p53-independent mechanism." | 3.71 | p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. ( El-Deiry, WS; Meng, RD, 2001) |
| "However, the effect of β-lapachone on metastasis of melanoma cells is unclear." | 1.46 | β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway. ( Han, YH; Hong, SH; Kee, JY; Kim, DS; Mun, JG; Park, R; Park, SH; Park, SJ; So, HS; Um, JY, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gomes, CL | 1 |
| de Albuquerque Wanderley Sales, V | 1 |
| Gomes de Melo, C | 1 |
| Ferreira da Silva, RM | 1 |
| Vicente Nishimura, RH | 1 |
| Rolim, LA | 1 |
| Rolim Neto, PJ | 1 |
| Kee, JY | 1 |
| Han, YH | 1 |
| Kim, DS | 1 |
| Mun, JG | 1 |
| Park, SH | 1 |
| So, HS | 1 |
| Park, SJ | 1 |
| Park, R | 1 |
| Um, JY | 1 |
| Hong, SH | 1 |
| Bang, W | 1 |
| Jeon, YJ | 1 |
| Cho, JH | 1 |
| Lee, RH | 1 |
| Park, SM | 1 |
| Shin, JC | 1 |
| Choi, NJ | 1 |
| Choi, YH | 1 |
| Cho, JJ | 1 |
| Seo, JM | 1 |
| Lee, SY | 1 |
| Shim, JH | 1 |
| Chae, JI | 1 |
| Meng, RD | 1 |
| El-Deiry, WS | 1 |
1 review available for beta-lapachone and Melanoma
| Article | Year |
|---|---|
Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis.
Topics: Anti-Infective Agents; Humans; Melanoma; Naphthoquinones; Wound Healing | 2021 |
3 other studies available for beta-lapachone and Melanoma
| Article | Year |
|---|---|
β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway.
Topics: Animals; Female; Humans; Lung Neoplasms; MAP Kinase Signaling System; Melanoma; Mice; Mice, Inbred C | 2017 |
β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Dow | 2016 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Topics: Antibiotics, Antineoplastic; Apoptosis; Betulinic Acid; Colonic Neoplasms; Dactinomycin; Dexamethaso | 2001 |