beta-lapachone has been researched along with Malignant Melanoma in 4 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, betulinic acid, a novel chemotherapeutic compound, induced apoptosis and KILLER/DR5 mRNA in melanoma and glioblastoma cells through a p53-independent mechanism." | 3.71 | p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. ( El-Deiry, WS; Meng, RD, 2001) |
| "However, the effect of β-lapachone on metastasis of melanoma cells is unclear." | 1.46 | β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway. ( Han, YH; Hong, SH; Kee, JY; Kim, DS; Mun, JG; Park, R; Park, SH; Park, SJ; So, HS; Um, JY, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gomes, CL | 1 |
| de Albuquerque Wanderley Sales, V | 1 |
| Gomes de Melo, C | 1 |
| Ferreira da Silva, RM | 1 |
| Vicente Nishimura, RH | 1 |
| Rolim, LA | 1 |
| Rolim Neto, PJ | 1 |
| Kee, JY | 1 |
| Han, YH | 1 |
| Kim, DS | 1 |
| Mun, JG | 1 |
| Park, SH | 1 |
| So, HS | 1 |
| Park, SJ | 1 |
| Park, R | 1 |
| Um, JY | 1 |
| Hong, SH | 1 |
| Bang, W | 1 |
| Jeon, YJ | 1 |
| Cho, JH | 1 |
| Lee, RH | 1 |
| Park, SM | 1 |
| Shin, JC | 1 |
| Choi, NJ | 1 |
| Choi, YH | 1 |
| Cho, JJ | 1 |
| Seo, JM | 1 |
| Lee, SY | 1 |
| Shim, JH | 1 |
| Chae, JI | 1 |
| Meng, RD | 1 |
| El-Deiry, WS | 1 |
1 review available for beta-lapachone and Malignant Melanoma
| Article | Year |
|---|---|
Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis.
Topics: Anti-Infective Agents; Humans; Melanoma; Naphthoquinones; Wound Healing | 2021 |
3 other studies available for beta-lapachone and Malignant Melanoma
| Article | Year |
|---|---|
β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway.
Topics: Animals; Female; Humans; Lung Neoplasms; MAP Kinase Signaling System; Melanoma; Mice; Mice, Inbred C | 2017 |
β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Dow | 2016 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Topics: Antibiotics, Antineoplastic; Apoptosis; Betulinic Acid; Colonic Neoplasms; Dactinomycin; Dexamethaso | 2001 |