beta-lapachone has been researched along with Hypertension in 4 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension is one of the most common human diseases worldwide, and extensive research efforts are focused upon the identification and utilizing of novel therapeutic drug targets." | 5.37 | Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. ( Gang, GT; Hwang, JH; Kim, DH; Kim, YH; Kwak, TH; Lee, CH; Lee, IK; Noh, JR; Shong, M; Son, HY, 2011) |
| "Hypertension is one of the most common human diseases worldwide, and extensive research efforts are focused upon the identification and utilizing of novel therapeutic drug targets." | 1.37 | Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. ( Gang, GT; Hwang, JH; Kim, DH; Kim, YH; Kwak, TH; Lee, CH; Lee, IK; Noh, JR; Shong, M; Son, HY, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, YH | 4 |
| Hwang, JH | 4 |
| Kim, KS | 3 |
| Noh, JR | 4 |
| Gang, GT | 4 |
| Kim, SW | 1 |
| Jang, SP | 1 |
| Lee, SJ | 1 |
| Her, SH | 1 |
| Jeong, KH | 2 |
| Kwak, TH | 4 |
| Park, WJ | 1 |
| Balyasnikova, IV | 1 |
| Shong, M | 2 |
| Lee, CH | 4 |
| Oh, WK | 1 |
| Choi, HS | 1 |
| Lee, IK | 2 |
| Seo, Y | 1 |
| Nam, KH | 1 |
| Lee, HG | 1 |
| Kim, DH | 1 |
| Son, HY | 1 |
4 other studies available for beta-lapachone and Hypertension
| Article | Year |
|---|---|
NQO1 activation regulates angiotensin-converting enzyme shedding in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Culture | 2013 |
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-media
Topics: AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cell Line; C | 2014 |
NAD(P)H:quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive rats.
Topics: Acetylation; Animals; Antihypertensive Agents; Blood Pressure; Cell Line; Disease Models, Animal; En | 2015 |
Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Topics: Acetylcholine; AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Blood Pressure; Calc | 2011 |