beta-lapachone has been researched along with Eye Cancer, Retinoblastoma in 2 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the cytotoxicity of beta-lapachone, a potent agent that may selectively target tumour cells, in retinoblastoma (RB) cell lines." | 7.74 | Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines. ( Conway, RM; Howard, SA; Madigan, MC; O'Brien, JM; Qi, J; Shah, HR; Van Quill, KR; Weinberg, V, 2008) |
| "Treatment with wortmannin or transfection with a dominant negative form of Akt anticipated at 24 h the effects induced by PTX/LPC, suggesting a protective role against apoptosis played by Akt in Y79 cells." | 5.36 | Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. ( Augello, G; D'Anneo, A; di Fiore, R; Giuliano, M; Messina, C; Santulli, A; Tesoriere, G; Vento, R, 2010) |
| "To investigate the cytotoxicity of beta-lapachone, a potent agent that may selectively target tumour cells, in retinoblastoma (RB) cell lines." | 3.74 | Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines. ( Conway, RM; Howard, SA; Madigan, MC; O'Brien, JM; Qi, J; Shah, HR; Van Quill, KR; Weinberg, V, 2008) |
| "Treatment with wortmannin or transfection with a dominant negative form of Akt anticipated at 24 h the effects induced by PTX/LPC, suggesting a protective role against apoptosis played by Akt in Y79 cells." | 1.36 | Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. ( Augello, G; D'Anneo, A; di Fiore, R; Giuliano, M; Messina, C; Santulli, A; Tesoriere, G; Vento, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| D'Anneo, A | 1 |
| Augello, G | 1 |
| Santulli, A | 1 |
| Giuliano, M | 1 |
| di Fiore, R | 1 |
| Messina, C | 1 |
| Tesoriere, G | 1 |
| Vento, R | 1 |
| Shah, HR | 1 |
| Conway, RM | 1 |
| Van Quill, KR | 1 |
| Madigan, MC | 1 |
| Howard, SA | 1 |
| Qi, J | 1 |
| Weinberg, V | 1 |
| O'Brien, JM | 1 |
2 other studies available for beta-lapachone and Eye Cancer, Retinoblastoma
| Article | Year |
|---|---|
Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.
Topics: Active Transport, Cell Nucleus; Androstadienes; Antineoplastic Agents, Phytogenic; Antineoplastic Co | 2010 |
Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Induct | 2008 |