Page last updated: 2024-10-30

beta-lapachone and Experimental Mammary Neoplasms

beta-lapachone has been researched along with Experimental Mammary Neoplasms in 1 studies

beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.

Research Excerpts

ExcerptRelevanceReference
"Phenformin is a mitochondrial complex I inhibitor that induces bioenergetic stress."5.62STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer. ( Aguilar-Mahecha, A; Ahn, R; Avizonis, D; Basik, M; Cepeda Cañedo, E; Chabot, C; Dankner, M; Goulet, ML; Hébert, S; Im, YK; Kleinman, CL; Kuasne, H; La Selva, R; Lebeau, B; Lewis, K; Lin, R; Martínez, C; Najyb, O; Nguyen, A; Park, M; Petrecca, K; Pollak, M; Sabourin, V; Santos Martínez, N; Savage, P; Siegel, PM; St-Pierre, J; Topisirovic, I; Totten, SP; Ursini-Siegel, J; Witcher, M, 2021)
"Phenformin is a mitochondrial complex I inhibitor that induces bioenergetic stress."1.62STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer. ( Aguilar-Mahecha, A; Ahn, R; Avizonis, D; Basik, M; Cepeda Cañedo, E; Chabot, C; Dankner, M; Goulet, ML; Hébert, S; Im, YK; Kleinman, CL; Kuasne, H; La Selva, R; Lebeau, B; Lewis, K; Lin, R; Martínez, C; Najyb, O; Nguyen, A; Park, M; Petrecca, K; Pollak, M; Sabourin, V; Santos Martínez, N; Savage, P; Siegel, PM; St-Pierre, J; Topisirovic, I; Totten, SP; Ursini-Siegel, J; Witcher, M, 2021)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Totten, SP1
Im, YK1
Cepeda Cañedo, E1
Najyb, O1
Nguyen, A1
Hébert, S1
Ahn, R1
Lewis, K1
Lebeau, B1
La Selva, R1
Sabourin, V1
Martínez, C1
Savage, P1
Kuasne, H1
Avizonis, D1
Santos Martínez, N1
Chabot, C1
Aguilar-Mahecha, A1
Goulet, ML1
Dankner, M1
Witcher, M1
Petrecca, K1
Basik, M1
Pollak, M1
Topisirovic, I1
Lin, R1
Siegel, PM1
Kleinman, CL1
Park, M1
St-Pierre, J1
Ursini-Siegel, J1

Other Studies

1 other study available for beta-lapachone and Experimental Mammary Neoplasms

ArticleYear
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.
    Nature communications, 2021, 06-03, Volume: 12, Issue:1

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Electron Transpo

2021