beta-lapachone has been researched along with Disease Models, Animal in 18 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacological activation of NADH oxidation by NQO1 resolves obesity and related phenotypes in mice, opening the possibility that it may provide the basis for a new therapy for the treatment of metabolic syndrome." | 7.75 | Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. ( Choi, HS; Chung, J; Han, J; Hwang, JH; Jang, C; Jo, EJ; Jo, YS; Kho, YL; Kim, DW; Kim, JM; Kim, YK; Kwak, TH; Kweon, GR; Kyung, T; Lee, I; Lee, SH; Park, JH; Park, MK; Shong, M; Yoo, SK, 2009) |
| "Hypertension is one of the most common human diseases worldwide, and extensive research efforts are focused upon the identification and utilizing of novel therapeutic drug targets." | 5.37 | Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. ( Gang, GT; Hwang, JH; Kim, DH; Kim, YH; Kwak, TH; Lee, CH; Lee, IK; Noh, JR; Shong, M; Son, HY, 2011) |
| "Pharmacological activation of NADH oxidation by NQO1 resolves obesity and related phenotypes in mice, opening the possibility that it may provide the basis for a new therapy for the treatment of metabolic syndrome." | 3.75 | Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. ( Choi, HS; Chung, J; Han, J; Hwang, JH; Jang, C; Jo, EJ; Jo, YS; Kho, YL; Kim, DW; Kim, JM; Kim, YK; Kwak, TH; Kweon, GR; Kyung, T; Lee, I; Lee, SH; Park, JH; Park, MK; Shong, M; Yoo, SK, 2009) |
| "Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase." | 1.56 | ( de A Pontes, ACA; de B Oliveira, AL; de Oliveira, AB; de Oliveira, JP; Dorneles, GP; Dos Santos, SM; Júnior, LCR; Monteiro, MC; Monteiro, VVS; Navegantes-Lima, KC; Quadros, LBG; Romão, PRT, 2020) |
| "Hypertension is one of the most common human diseases worldwide, and extensive research efforts are focused upon the identification and utilizing of novel therapeutic drug targets." | 1.37 | Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. ( Gang, GT; Hwang, JH; Kim, DH; Kim, YH; Kwak, TH; Lee, CH; Lee, IK; Noh, JR; Shong, M; Son, HY, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, TS | 1 |
| Liu, Y | 1 |
| Tucker, T | 1 |
| Daniel, KR | 1 |
| Sane, DC | 1 |
| Toone, E | 1 |
| Burke, JR | 1 |
| Strittmatter, WJ | 1 |
| Greenberg, CS | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Soares, RN | 1 |
| Ximenes, ECPA | 1 |
| Araújo, SB | 1 |
| Silva, RLD | 1 |
| Souza, VMO | 1 |
| Coelho, LCBB | 1 |
| Neto, JLF | 1 |
| Neto, PJR | 1 |
| Araújo, HDA | 1 |
| Aires, AL | 1 |
| Albuquerque, MCPA | 1 |
| Cascabulho, CM | 1 |
| Meuser-Batista, M | 1 |
| Moura, KCG | 1 |
| Pinto, MDC | 1 |
| Duque, TLA | 1 |
| Demarque, KC | 1 |
| Guimarães, ACR | 1 |
| Manso, PPA | 1 |
| Pelajo-Machado, M | 1 |
| Oliveira, GM | 1 |
| Castro, SL | 1 |
| Menna-Barreto, RF | 1 |
| de B Oliveira, AL | 1 |
| Navegantes-Lima, KC | 1 |
| Monteiro, VVS | 1 |
| Quadros, LBG | 1 |
| de Oliveira, JP | 1 |
| Dos Santos, SM | 1 |
| de A Pontes, ACA | 1 |
| Dorneles, GP | 1 |
| Romão, PRT | 1 |
| Júnior, LCR | 1 |
| de Oliveira, AB | 1 |
| Monteiro, MC | 1 |
| Yang, Y | 1 |
| Zhou, X | 1 |
| Xu, M | 1 |
| Piao, J | 1 |
| Zhang, Y | 1 |
| Lin, Z | 1 |
| Chen, L | 1 |
| Shin, S | 1 |
| Park, J | 2 |
| Li, Y | 1 |
| Min, KN | 2 |
| Kong, G | 1 |
| Hur, GM | 1 |
| Kim, JM | 2 |
| Shong, M | 4 |
| Jung, MS | 1 |
| Park, JK | 1 |
| Jeong, KH | 3 |
| Park, MG | 2 |
| Kwak, TH | 5 |
| Brazil, DP | 1 |
| Morales, J | 1 |
| Li, L | 1 |
| Fattah, FJ | 1 |
| Dong, Y | 1 |
| Bey, EA | 1 |
| Patel, M | 1 |
| Gao, J | 1 |
| Boothman, DA | 2 |
| Kim, YH | 2 |
| Hwang, JH | 4 |
| Kim, KS | 1 |
| Noh, JR | 2 |
| Gang, GT | 2 |
| Seo, Y | 1 |
| Nam, KH | 1 |
| Lee, HG | 1 |
| Lee, CH | 2 |
| Lee, EJ | 1 |
| Ko, HM | 1 |
| Jeong, YH | 1 |
| Park, EM | 1 |
| Kim, HS | 1 |
| Li, LS | 1 |
| Reddy, S | 1 |
| Lin, ZH | 1 |
| Liu, S | 1 |
| Park, H | 1 |
| Chun, SG | 1 |
| Bornmann, WG | 1 |
| Thibodeaux, J | 1 |
| Yan, J | 1 |
| Chakrabarti, G | 1 |
| Xie, XJ | 1 |
| Sumer, BD | 1 |
| Yordy, JS | 1 |
| Kim, AY | 1 |
| Lee, JH | 1 |
| Kang, Y | 1 |
| Lee, SH | 2 |
| Baik, EJ | 1 |
| Kim, DW | 1 |
| Jo, EJ | 1 |
| Kim, YK | 1 |
| Jo, YS | 1 |
| Park, JH | 1 |
| Yoo, SK | 1 |
| Park, MK | 1 |
| Kho, YL | 1 |
| Han, J | 1 |
| Choi, HS | 1 |
| Lee, I | 1 |
| Kyung, T | 1 |
| Jang, C | 1 |
| Chung, J | 1 |
| Kweon, GR | 2 |
| Kim, SY | 1 |
| Jeoung, NH | 1 |
| Oh, CJ | 1 |
| Choi, YK | 1 |
| Lee, HJ | 1 |
| Kim, HJ | 1 |
| Kim, JY | 1 |
| Tadi, S | 1 |
| Yim, YH | 1 |
| Lee, KU | 1 |
| Park, KG | 1 |
| Huh, S | 1 |
| Inukai, K | 1 |
| Lee, IK | 2 |
| Kim, DH | 1 |
| Son, HY | 1 |
| Xu, J | 1 |
| Wagoner, G | 1 |
| Douglas, JC | 1 |
| Drew, PD | 1 |
| Tzeng, HP | 1 |
| Ho, FM | 1 |
| Chao, KF | 1 |
| Kuo, ML | 1 |
| Lin-Shiau, SY | 1 |
| Liu, SH | 1 |
1 review available for beta-lapachone and Disease Models, Animal
| Article | Year |
|---|---|
Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.
Topics: Animals; Disease Models, Animal; DNA Repair; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Molecul | 2014 |
17 other studies available for beta-lapachone and Disease Models, Animal
| Article | Year |
|---|---|
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
Topics: Animals; Calcium; Combinatorial Chemistry Techniques; Disease Models, Animal; Drosophila melanogaste | 2008 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Evaluation of β-lapachone-methyl-β-cyclodextrin inclusion complex prepared by spray drying and its application against different developmental stages of Schistosoma mansoni in murine model.
Topics: Animals; Disease Models, Animal; Mice; Naphthoquinones; Schistosoma mansoni; Spray Drying | 2023 |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocar | 2020 |
Topics: Animals; Anti-Inflammatory Agents; Chemoprevention; Cytokines; Disease Models, Animal; Immunosuppres | 2020 |
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; D | 2017 |
β-Lapachone alleviates alcoholic fatty liver disease in rats.
Topics: Alcohol Dehydrogenase; Aldehyde Dehydrogenase; AMP-Activated Protein Kinases; Animals; Cells, Cultur | 2014 |
NAD(P)H:quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive rats.
Topics: Acetylation; Animals; Antihypertensive Agents; Blood Pressure; Cell Line; Disease Models, Animal; En | 2015 |
β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cells, Cultured; Cytokines; Disease Models, Animal; En | 2015 |
NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer.
Topics: Adenosine Triphosphate; Animals; Catalase; Cell Death; Cell Line, Tumor; Cell Survival; Disease Mode | 2016 |
Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion.
Topics: Animals; Astrocytes; Brain; Brain Ischemia; Cell Death; Cells, Cultured; Coculture Techniques; Disea | 2017 |
Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.
Topics: Adenylate Kinase; Animals; Disease Models, Animal; Energy Metabolism; Metabolic Syndrome; Mice; Mice | 2009 |
Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals | 2009 |
Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Topics: Acetylcholine; AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Blood Pressure; Calc | 2011 |
β-Lapachone ameliorization of experimental autoimmune encephalomyelitis.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Bone Marro | 2013 |
beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality.
Topics: Animals; Anti-Infective Agents; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinica | 2003 |