beta-lapachone has been researched along with Cell Transformation, Neoplastic in 5 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most chemotherapeutic drugs kill cancer cells by indirectly activating checkpoint-mediated apoptosis after creating nonselective damage to DNA or microtubules, which accounts for their toxicity toward normal cells." | 1.32 | Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer. ( LaMont, JT; Li, CJ; Li, Y; Pardee, AB; Sun, X, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Sun, X | 1 |
| LaMont, JT | 1 |
| Pardee, AB | 3 |
| Li, CJ | 1 |
| Bentle, MS | 1 |
| Bey, EA | 1 |
| Dong, Y | 1 |
| Reinicke, KE | 1 |
| Boothman, DA | 4 |
| Schlegel, R | 1 |
2 reviews available for beta-lapachone and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors.
Topics: Anticarcinogenic Agents; Cell Transformation, Neoplastic; DNA Breaks, Double-Stranded; DNA Breaks, S | 2006 |
Anticarcinogenic potential of DNA-repair modulators.
Topics: Animals; Antibiotics, Antineoplastic; Carcinogens; Cell Transformation, Neoplastic; DNA Damage; DNA | 1988 |
3 other studies available for beta-lapachone and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell C | 2003 |
Enhanced malignant transformation is accompanied by increased survival recovery after ionizing radiation in Chinese hamster embryo fibroblasts.
Topics: Animals; Camptothecin; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Cells | 1994 |
Inhibition of radiation-induced neoplastic transformation by beta-lapachone.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA | 1989 |