beta-lapachone has been researched along with Cancer of Colon in 5 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, betulinic acid, a novel chemotherapeutic compound, induced apoptosis and KILLER/DR5 mRNA in melanoma and glioblastoma cells through a p53-independent mechanism." | 3.71 | p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma. ( El-Deiry, WS; Meng, RD, 2001) |
| "Human colon cancers have a high frequency of p53 mutations, and cancer cells expressing mutant p53 tend to be resistant to current chemo- and radiation therapy." | 1.30 | beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells. ( Huang, L; Pardee, AB, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, N | 1 |
| Zhao, Y | 1 |
| Ge, N | 1 |
| Qian, L | 1 |
| Liu, Y | 1 |
| Kwon, T | 1 |
| Kim, JS | 1 |
| Chandimali, N | 1 |
| Jin, YH | 1 |
| Gong, YX | 1 |
| Xie, DP | 1 |
| Han, YH | 1 |
| Jin, MH | 1 |
| Shen, GN | 1 |
| Jeong, DK | 1 |
| Lee, DS | 1 |
| Cui, YD | 1 |
| Sun, HN | 1 |
| Liu, H | 1 |
| Li, Q | 1 |
| Cheng, X | 1 |
| Wang, H | 1 |
| Wang, G | 1 |
| Hao, H | 1 |
| Huang, L | 1 |
| Pardee, AB | 1 |
| Meng, RD | 1 |
| El-Deiry, WS | 1 |
5 other studies available for beta-lapachone and Cancer of Colon
| Article | Year |
|---|---|
A pH/ROS cascade-responsive and self-accelerating drug release nanosystem for the targeted treatment of multi-drug-resistant colon cancer.
Topics: Animals; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Dextrans; Drug Carriers; Drug Delivery | 2020 |
Peroxiredoxin V Reduces β-Lapachone-induced Apoptosis of Colon Cancer Cells.
Topics: Apoptosis; Cell Line, Tumor; Colon; Colonic Neoplasms; Humans; Naphthoquinones; Peroxiredoxins; Reac | 2019 |
UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Drug Resistance, Neoplasm; Forkhead Box Protein | 2015 |
beta-lapachone induces cell cycle arrest and apoptosis in human colon cancer cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Cycle Proteins; | 1999 |
p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Topics: Antibiotics, Antineoplastic; Apoptosis; Betulinic Acid; Colonic Neoplasms; Dactinomycin; Dexamethaso | 2001 |