beta-ionone and Staphylococcal-Infections

A series of chalcones (3a-v) have been synthesized by condensation of β-ionone (1) with a variety of aldehydes (2a-v). The synthesized compounds have been screened for their in vitro antimicrobial activity against five bacterial and five fungal strains, using disc diffusion assay. The evaluated compounds display a wide range of activities, from completely inactive to the highly active compounds. Some of the compounds are also active against methicillin resistant staphylococcus aureus (MRSA).

Topics: Anti-Infective Agents; Bacteria; Bacterial Infections; Chalcones; Fungi; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mycoses; Norisoprenoids; Staphylococcal Infections

Topics: Ammonium Compounds; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chemistry, Pharmaceutical; Escherichia coli; Mice; Norisoprenoids; Pharmacology; Pseudomonas aeruginosa; Pseudomonas Infections; Quaternary Ammonium Compounds; Research; Salmonella typhi; Staphylococcal Infections; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Toxicology