beta-hederin has been researched along with Liver-Neoplasms* in 1 studies
1 other study(ies) available for beta-hederin and Liver-Neoplasms
Article | Year |
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CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells.
An antibody that specifically interacts with an antigen could be applied to an active targeting delivery system. In this study, CD147 antibody was coupled with α-hed chitosan nanoparticles (α-Hed-CS-NPs). α-Hed-CS-CD147-NPs were round and spherical in shape, with an average particle size of 148.23 ± 1.75 nm. The half-maximum inhibiting concentration (IC50) of α-Hed-CS-CD147-NPs in human liver cancer cell lines HepG2 and SMMC-7721 was lower than that of free α-Hed and α-Hed-CS-NPs. α-Hed-induced cell death was mainly triggered by apoptosis. The increase in intracellular accumulation of α-Hed-CS-CD147-NPs was also related to CD147-mediated internalization through the Caveolae-dependent pathway and lysosomal escape. The higher targeting antitumor efficacy of α-Hed-CS-CD147-NPs than that α-Hed-CS-NPs was attributed to its stronger fluorescence intensity in the tumor site in nude mice. Topics: Animals; Annexin A5; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Basigin; Chitosan; Endocytosis; Flow Cytometry; Fluorescence; Hep G2 Cells; Humans; Imaging, Three-Dimensional; Intracellular Space; Liver Neoplasms; Mice, Nude; Microscopy, Confocal; Nanoparticles; Oleanolic Acid; Particle Size; Propidium; Saponins; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Near-Infrared; Subcellular Fractions | 2015 |