beta-escin and Acute-Kidney-Injury

A case of acute renal insufficiency after therapy with gentamycin and beta-Aescin is reported. The role of these two agents in the causation of the acute renal failure is discussed. Renal function was restored using the REDY-Hemodialization System.

Topics: Acute Kidney Injury; Adult; Drug Interactions; Escin; Gentamicins; Humans; Male; Postoperative Complications; Renal Dialysis; Saponins

Topics: Acute Kidney Injury; Brain Concussion; Child; Crush Syndrome; Dextrans; Dose-Response Relationship, Drug; Edema; Escin; Fractures, Bone; Humans; Male; Saponins; Shock, Traumatic; Skull Fractures

The incidence of acute renal failure following cardiac surgery was markedly increased during the last years in our medical center. There was no correlation to known etiologic factors such as preexisting disease, hemolysis, low perfusion rates, post-operative low output syndrome etc. Post-operative renal failure was mainly seen in children between 2 and 10 years and was noted after 3-4 days of normal renal function. Peritoneal dialysis was carried out in 39% of out patients and the overall mortality was 10.7%. Careful analysis of our cases exhibited a correlation of the post operative acute renal failure to the intravenous application of Aescin. After abandoning this drug from our post-operative therapy we did not observe a similar case since almost one year.

Topics: Acute Kidney Injury; Child; Child, Preschool; Escin; Female; Heart Diseases; Humans; Peritoneal Dialysis; Postoperative Complications; Saponins; Time Factors

Topics: Acute Kidney Injury; Aesculus; Drug Combinations; Drug Hypersensitivity; Escin; Injections, Intravenous; Plant Extracts; Shock; Thiamine; Toxicology