beta-endorphin and Erythema

Chlorpropamide-alcohol flushing may be due to sensitivity to endogenous opiates. To investigate this possibility the plasma met-enkephalin and beta-endorphin responses to sherry with and without chlorpropamide were studied in six patients with non-insulin dependent diabetes and in six normal subjects. After chlorpropamide all patients showed a rise in met-enkephalin concentrations from a basal level of 50 +/- 7.2 ng/l to a peak of 75 +/- 8.1 ng/l (p less than 0.001). In contrast, before chlorpropamide treatment was started met-enkephalin values did not change after alcohol. No significant changes in beta-endorphin values were observed. In six normal subjects pretreated with chlorpropamide the met-enkephalin concentration also rose from a basal level of 72 +/- 15 ng/l to a peak of 103 +/- 9.4 ng/l (p less than 0.002). Again, the met-enkephalin rise was not observed after placebo. Neither beta-endorphin concentrations nor facial temperature changed significantly. These data suggest that endogenous opiates may be implicated in CPAF. Furthermore, this is the first study in which a significant change in circulating met-enkephalin values has occurred.

Topics: beta-Endorphin; Chlorpropamide; Diabetes Mellitus; Double-Blind Method; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Erythema; Face; Female; Humans; Male; Wine

Topics: Adult; beta-Endorphin; Dose-Response Relationship, Radiation; Endorphins; Epinephrine; Erythema; Heart Rate; Humans; Male; Norepinephrine; Oxygen; Physical Exertion; Spirometry; Sunlight; Ultraviolet Rays