beta-endorphin and Dermatitis

Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear.. C57BL/6j male mice were irradiated with UVB (1.0 kJ/m2/day) for 3 days. Five days after the final session of UVB irradiation, the dorsal skin, ear epidermis, and blood samples were analyzed to investigate the inflammatory factors, melanogenesis factors and related hormones.. After the oral administration of CA (100 mg/day) or CGA (100 mg/day) for 8 days, only CA was found to inhibit dermatitis and pigmentation. The pathway by which CA inhibits dermatitis is related to the mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK)1/2/cAMP response element binding protein (CREB) pathway. Otherwise, the pathway by which CA inhibits pigmentation is related to the activation of the β-endorphin-μ-opioid receptor and suppresses the cAMP-microphthalmia-associated transcription factor (MITF) pathway.. It is suggested that the oral administration of CA prevented dermatitis and pigmentation after UVB irradiation in mice.

Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; beta-Endorphin; Caffeic Acids; Chlorogenic Acid; Coffee; Dermatitis; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Skin; Skin Pigmentation; Ultraviolet Rays

Topics: Arthritis, Rheumatoid; beta-Endorphin; Dermatitis; Humans; Immunity, Innate; Interleukin 1 Receptor Antagonist Protein; Killer Cells, Natural; Pain; Sialoglycoproteins; Stress, Physiological; Superoxide Dismutase