beta-endorphin and Demyelinating-Diseases

The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturally occurring neuropeptide, beta-endorphin, reduced the incidence of JHMV-induced paralytic-demyelinating disease 40-50% in C57Bl/6 mice. Protection from disease was accompanied by significantly reduced virus replication in the brain as early as 3 days post-infection and did not occur in irradiated, or immunoincompetent mice. The data suggest that beta-endorphin engages immune mechanisms of host resistance to JHMV infection to protect the mice from disease.

Topics: Amino Acid Sequence; Animals; Antibodies, Viral; beta-Endorphin; Brain; Coronavirus Infections; Demyelinating Diseases; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Murine hepatitis virus; Paralysis; Structure-Activity Relationship; Virus Replication; Whole-Body Irradiation