beta-elemene has been researched along with Leukemia* in 3 studies
3 other study(ies) available for beta-elemene and Leukemia
| Article | Year |
|---|---|
Combination of chemotherapy and gaseous signaling molecular therapy: Novel β-elemene nitric oxide donor derivatives against leukemia.
This study aimed to design and synthesize active hybrids of β-elemene and nitric oxide (NO) donor pharmacophore as potential agents for treating leukemia. Derivatives reported herein exerted better inhibitory effects against human chronic myeloid leukemia K562 cells compared to β-elemene (IC Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; K562 Cells; Leukemia; Mice; Nitric Oxide; Nitric Oxide Donors; Sesquiterpenes | 2023 |
N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway.
Beta-elemene is an active component of herb medicine Curcuma Wenyujin and N-(beta-elemene-13-yl)tryptophan methyl ester (ETME) was synthesized for increasing its antitumor activity. ETME induced apoptosis in human leukemia HL-60 and NB4 cells at concentrations less than 40 microM. The apoptosis induction ability of ETME was associated with the production of hydrogen peroxide (H(2)O(2)), the decrease of mitochondrial membrane potential, and the activation of caspase-3 that was blocked by catalase. ETME in combination with arsenic trioxide (As(2)O(3)), an agent used to treat acute promyelocytic leukemia, synergistically induced apoptosis in both cell lines by enhanced production of H(2)O(2). These data suggest that ETME induces apoptosis and synergizes with As(2)O(3) in leukemia cells through a H(2)O(2)-dependent pathway. Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Catalase; Cell Proliferation; Cell Survival; Drug Synergism; HL-60 Cells; Humans; Hydrogen Peroxide; Leukemia; Oxides; Sesquiterpenes; Tryptophan | 2008 |
[beta-elemene induces apoptosis of K562 leukemia cells].
To investigate the apoptosis-inducing effect of beta-elemene on K562 leukemia cells.. Hoechst 33342 and PI fluorescence staining, DNA fragmentation, electron microscopy, flow cytometry, and immunocytochemistry were used to evaluate the effect of beta-elemene on K562 cells.. beta-elemene heatment induced the formation of apoptotic bodies and DNA ladder. The effect was dose- and time-dependent. The expression of bcl-2 was decreased in beta-elemene treated cells as compared with the untreated control cells.. beta-elemene exerts its cytotoxic effect on K562 leukemic cells by the induction of apoptosis. Topics: Apoptosis; DNA Fragmentation; Dose-Response Relationship, Drug; Gene Expression; Genes, bcl-2; Humans; Immunohistochemistry; K562 Cells; Leukemia; Plant Extracts; Sesquiterpenes | 2001 |