beta-carotene and Tuberculosis--Pulmonary

To investigate vitamin A (VA), vitamin E (VE) and beta-carotene nutritional status and antioxidase level among tuberculosis patients.. Totally 70 tuberculosis patients were randomly selected as the experiment group from Tancheng Tuberculosis Control in 2010. And 70 matched normal persons were selected as the control group. Two groups of people were relative nutrition index test which include body mass index (BMI), hemoglobin (Hb), triglyceride (TG), total cholesterol ( TC) , high-density lipoprotein (HDL), superoxide dismutase (SOD), catalase (CAT), VA, VE and beta-carotene.. BMI of the experiment group was 19.13, which was obviously lower than those of the control group which was 21.95 (P<0.05), but Hb of the experiment group was 128.36 g/L which was lower than those of the control group, not with significant statistic differences. For blood lipid level, TG, TC, HDL of the experiment group were 1.54, 4.47 and 1.21 mmol/L respectively, compared with corresponding indexes of the control group which were 1.63, 5.20, 1.30 mmol/L respectively, were all dramatic decline (P<0.05). Antioxidase level contrast between two groups showed that SOD and CAT of the experiment group were 78.20 and 5.24 U/ml respectively, and corresponding indexes of the control group were 83.27 and 9.99 U/ml respectively, so the former was significantly lower than the later (P<0.05); compared with the control group on vitamin level, VA, VE of the experiment group were 0.256 and 1.148 microg/ml respectively which were all lower than the control group which were 0.385 and 1.182 microg/ml (P<0.05), but beta-carotene of the experiment group was 0.048 microg/ml which was slightly lower than 0.051 microg/ml of the control group, not with significant statistic differences.. Nutritional status among the tuberculosis patients is quite poor, especially antioxidase and VA, VE and beta-carotene level are significantly lower than normal people.

Topics: Adult; Aged; Aged, 80 and over; Antioxidants; beta Carotene; Body Mass Index; Case-Control Studies; Catalase; Female; Humans; Male; Middle Aged; Nutritional Status; Sampling Studies; Superoxide Dismutase; Tuberculosis, Pulmonary; Vitamin A; Vitamin E; Young Adult

Inflammation-related oxidative stress has been implicated in the pathogenesis of lung fibrosis and dysfunction in patients with pulmonary tuberculosis.. To investigate the effects of antimicrobial chemotherapy and smoking status on the plasma concentrations of the anti-oxidative nutrients vitamin C, vitamin E and beta-carotene, as well as those of iron, lipid peroxides and the acute phase reactants C-reactive protein (CRP) and ferritin.. A total of 41 patients with active pulmonary tuberculosis were studied at the outset and after 6 months of antimicrobial chemotherapy.. Initial plasma concentrations of vitamin C and beta-carotene were low, returning to normal values after chemotherapy in the non-smokers, but not in the smokers, while those of vitamin E remained low throughout in both groups. Ferritin and CRP concentrations decreased significantly following chemotherapy, with the former higher in smokers than in non-smokers. Serum lipid peroxides were elevated in patients with pulmonary tuberculosis and were unaffected by chemotherapy or smoking habits, while iron levels were not significantly affected by chemotherapy. Although residual dysfunction and infiltration were evident, pulmonary function (FEV1) and radiographic score improved equally in both smokers and non-smokers following antimicrobial chemotherapy.. Even after 6 months of apparently successful antimicrobial chemotherapy, pulmonary tuberculosis is associated with increased oxidative stress, which is unrelated to cigarette smoking and characterized by increased levels of circulating lipid peroxides and low concentrations of plasma vitamin E.

Topics: Acute-Phase Proteins; Adult; Antioxidants; Antitubercular Agents; Ascorbic Acid; beta Carotene; Female; Humans; Iron; Lipid Peroxides; Male; Middle Aged; Oxidative Stress; Respiratory Function Tests; Smoking; Tuberculosis, Pulmonary; Vitamin E

Topics: Ascorbic Acid; beta Carotene; Carotenoids; Humans; Plasma; Research; Tuberculosis; Tuberculosis, Pulmonary; Vitamin A; Vitamin K; Vitamins