beta-carotene and Sarcoma-180

The effect of intraperitoneal injection of beta-carotene in different doses on the formation of cytolytic T lymphocytes (CTL) in a one-way mixed lymphocyte culture (MLC) of allogeneic mice was studied. The maximal cytotoxic activity of lymphocytes was attained in the MLC with splenocytes of mice which received 10 mg/kg beta-carotene 6 days before experimentation. The correlation was studied between the beta-carotene ability to stimulate CTL formation and antineoplastic activity. It was discovered that injection of beta-carotene in doses and times provoking maximal CTL induction had no effect on the animals' lifespan and the size of transplanted sarcoma 180.

Topics: Animals; Antineoplastic Agents; beta Carotene; Carotenoids; Lymphocyte Culture Test, Mixed; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Sarcoma 180; T-Lymphocytes, Cytotoxic