beta-carotene and Pulmonary-Disease--Chronic-Obstructive

Chronic obstructive pulmonary disease (COPD) is one of the most important and prevalent diseases suffered by the elderly. Evidence exists that its onset and severity might be conditioned by antioxidant status. The aim of the present study was to investigate the relationship between antioxidant status and COPD in institutionalised elderly people. In all, 183 elderly people aged >65 years (twenty-one had COPD and 160 healthy controls) were studied. The subjects' diets were investigated via the use of precise individual weighing for 7 d. Body weight, height, and biceps and triceps skinfold thickness were measured, and body fat (kg) and BMI (kg/m2) were calculated. Serum retinol, α-tocopherol, β-carotene and vitamin C levels were determined. Subjects with COPD ate less fruits than healthy controls (117 (sd 52) v. 192 (sd 161) g/d), their coverage of the recommended intake of vitamin C was smaller (150 (sd 45) v. 191 (sd 88) %; note that both exceeded 100 %) and their diets had a lower antioxidant capacity (6558 (sd 2381) v. 9328 (sd 5367) mmol trolox equivalent/d). Those with COPD had lower serum vitamin C and α-tocopherol concentrations than healthy controls (32·4 (sd 15·3) v. 41·5 (sd 14·8) µmol/l and 12·1 (sd 3·2) v. 13·9 (sd 2·8) µmol/l, respectively). In addition, subjects with α-tocopherol <14·1µmol/l (50th percentile) were at 6·43 times greater risk of having COPD than those subjects with ≥14·1µmol/l (OR 6·43; 95 % CI 1·17, 35·24; P<0·05), taking sex, age, use of tobacco, body fat and vitamin E intake as covariables. Subjects with COPD had diets of poorer antioxidant quality, especially with respect to vitamins C and E, compared with healthy controls.

Topics: Aged; Aged, 80 and over; alpha-Tocopherol; Antioxidants; Ascorbic Acid; beta Carotene; Biomarkers; Body Mass Index; Body Weight; Case-Control Studies; Diet; Female; Fruit; Humans; Male; Pulmonary Disease, Chronic Obstructive; Vitamin E

To investigate the prevalence and type of dietary supplements taken by Japanese patients with chronic obstructive pulmonary disease (COPD) and factors affecting their use.. Cross-sectional study by face-to-face interviews.. Six hospitals in central Japan.. Of the 300 referred COPD patients aged between 50 and 75 years, 278 eligible participants (244 men and 34 women) with complete data were available for analysis.. Prevalence of supplement use, dietary supplement categories (multivitamin, beta-carotene, vitamin C, vitamin E, and miscellaneous).. Overall, 42% of participants were dietary supplement users taking at least one category of supplements weekly; the prevalence being higher for female (47%) than male patients (41%). The most common supplements consumed were energy drink for men (11.1%), and multivitamin (11.8%) and vinegar (11.8%) for women. Dietary supplementation was found to be affected by age (p=0.04), COPD severity (p=0.03) and presence of co-morbidity (p=0.03). Older patients over 60 years were more likely to take dietary supplements (odds ratio (OR) 2.44, 95% CI 1.03-5.80), whereas severe COPD patients (OR 0.41, 95% CI 0.18-0.95) and those with a co-morbidity (OR 0.54, 95% CI 0.32-0.94) tended not to use.. Dietary supplements are popular for patients with COPD especially among older patients. The findings are important to clinical trials and experimental interventions advocating nutritional supplementation therapy for pulmonary rehabilitation.

Topics: Acetic Acid; Aged; Antioxidants; Ascorbic Acid; beta Carotene; Cross-Sectional Studies; Dietary Supplements; Female; Forced Expiratory Volume; Health Behavior; Humans; Japan; Logistic Models; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Vitamins

Topics: Adult; Aged; Ascorbic Acid; Asthma; beta Carotene; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Coronary Disease; Disease; Disease Susceptibility; Epidemiologic Factors; Female; Heart Transplantation; Humans; Incidence; Male; Men; Middle Aged; Neoplasms; Pregnancy; Prognosis; Pulmonary Disease, Chronic Obstructive; Risk Factors; Sex Factors