beta-carotene and Metabolic-Diseases

Observational studies evaluating the relation between dietary or circulating level of beta-carotene and risk of total mortality yielded inconsistent results. We conducted a comprehensive search on publications of PubMed and EMBASE up to 31 March 2016. Random effect models were used to combine the results. Potential publication bias was assessed using Egger's and Begg's test. Seven studies that evaluated dietary beta-carotene intake in relation to overall mortality, indicated that a higher intake of beta-carotene was related to a significant lower risk of all-cause mortality (RR for highest vs. lowest group = 0.83, 95%CI: 0.78-0.88) with no evidence of heterogeneity between studies (I(2) = 1.0%, P = 0.416). A random-effect analysis comprising seven studies showed high beta-carotene level in serum or plasma was associated with a significant lower risk of all-cause mortality (RR for highest vs. lowest group = 0.69, 95%CI: 0.59-0.80) with low heterogeneity (I(2) = 37.1%, P = 0.145). No evidence of publication bias was detected by Begg's and Egger's regression tests. In conclusion, dietary or circulating beta-carotene was inversely associated with risk of all-cause mortality. More studies should be conducted to clarify the dose-response relationship between beta-carotene and all-cause mortality.

Topics: Adult; Aged; Aged, 80 and over; beta Carotene; Cardiovascular Diseases; Diet; Female; Humans; Male; Metabolic Diseases; Middle Aged; Neoplasms; Phytochemicals; Prospective Studies; Survival Analysis

Topics: Alzheimer Disease; Animals; Antioxidants; Apoptosis; beta Carotene; Carotenoids; Humans; Metabolic Diseases; Neoplasms; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Retinoids; Tretinoin; Vitamin A

The combination of sarcopenia and obesity (i.e., sarcopenic obesity) is more strongly associated with disability and metabolic/cardiovascular diseases than obesity or sarcopenia alone. Therefore, countermeasures that simultaneously suppress fat gain and muscle atrophy to prevent an increase in sarcopenic obesity are warranted. The aim of this study was to investigate the simultaneous effects of fucoxanthinol (FXOH) on fat loss in mature adipocytes and the inhibition of atrophy and loss in myotubes induced by oxidative stress. C2C12 myotubes were treated with FXOH for 24 h and further incubated with hydrogen peroxide (H

Topics: 3T3-L1 Cells; Adipocytes; Animals; Atrophy; beta Carotene; Cell Line; Fatty Acids; Hydrogen Peroxide; Lipolysis; Metabolic Diseases; Mice; Muscle Fibers, Skeletal; Muscular Atrophy; Obesity; Oxidative Stress; Triglycerides

Cancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer according to tumor-node-metastasis (TNM) stages.. A total of 194 patients with oral cancer were enrolled in this study. The patients were stratified for four groups according to cancer stages and that the statistics are comparisons across these groups. The levels of antioxidant vitamins (ubiquinone, β-carotene, vitamin A and E), metabolic parameters, oxidative stress, antioxidant enzymes activity, and inflammatory markers were measured.. More than half of the subjects had high blood pressure, central obesity, hyperglycemia, and hyperlipidemia regardless of TNM stage. With regard to antioxidant vitamins status, 46 and 94% of patients had β-carotene and ubiquinone deficiency, respectively. Patients in T3 and T4 stages had significantly lower antioxidant enzyme (catalase, p = 0.03) activity and higher inflammatory markers levels (high sensitivity C-reactive protein and interleukin-6, p < 0.01) than patients in the other stages. In addition, the level of β-carotene was negatively associated with waist circumference, and ubiquinone was positively associated with the level of high-density lipoprotein cholesterol (p < 0.05). Higher β-carotene and ubiquinone levels were negatively associated with hypertriglyceridemia and the risk of metabolic syndrome (p < 0.05).. A high proportion of patients with oral cancer had ubiquinone or β-carotene deficiency and metabolic disorders. The level of ubiquinone or β-carotene was negatively associated with the risk of central obesity, hypertriglyceridemia, and metabolic syndrome. Since patients with oral cancer suffer from high oxidative stress and inflammation (particularly in the T3 and T4 stages), supplementation with antioxidant vitamins such as ubiquinone or β-carotene could be preferentially applied.

Topics: Adult; Aged; beta Carotene; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Interleukin-6; Male; Metabolic Diseases; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Oxidative Stress; Ubiquinone; Vitamin A; Vitamin E

Using archival data, we conducted a secondary analysis to examine race differences in the relation of serum vitamins A, C, E and β-carotene to insulin resistance (IR), fasting insulin and glucose, high sensitivity C-reactive protein (hs-CRP), and leukocyte count in 176 non-smoking, healthy, white, and African American (AA) adults aged 18 to 65 years (48% women, 33% AA). We hypothesized that micronutrient concentrations would be associated with early risk markers of cardiometabolic diseases in a race-dependent manner. Fasting blood samples were analyzed for micronutrients, insulin, glucose, hs-CRP, and leukocyte count. Insulin resistance was estimated using the homeostatic model assessment. After adjusting for age, body mass index, gender, educational level, use of vitamin supplements, alcohol intake, leisure time physical activity, menopausal status, and total cholesterol, we observed that β-carotene was significantly associated with insulin resistance and fasting insulin in a race-dependent manner. Among AA, lower β-carotene levels were associated with higher estimates of insulin resistance and fasting insulin; whereas, these same associations were not significant for whites. Race also significantly moderated the relation of vitamin C to leukocyte count, with lower vitamin C being associated with higher leukocyte count only in AA but not whites. For all subjects, lower β-carotene was associated with higher hs-CRP. In AA, but not whites, lower levels of β-carotene and vitamin C were significantly associated with early risk markers implicated in cardiometabolic conditions and cancer. Whether or not lower levels of micronutrients contribute uniquely to racial health disparities is a worthwhile aim for future research.

Topics: Adiposity; Adolescent; Adult; Aged; Ascorbic Acid; beta Carotene; Biomarkers; Black or African American; Blood Glucose; C-Reactive Protein; Female; Humans; Inflammation; Insulin; Insulin Resistance; Leukocyte Count; Male; Metabolic Diseases; Middle Aged; Racial Groups; Risk Factors; Vitamin A; Vitamin E; Vitamins; White People

Some of the main nutritional reasons for recommending a Mediterranean diet is to prevent metabolic diseases arising through free radical formation. A key constituent compound is beta-carotene which, amongst the carotenoids, displays the greatest provitamin A activity as well as possessing significant antioxidant properties.. Principally, to determine the relationship between serum beta-carotene levels and the effect of Mediterranean diet guidelines in a selected group of women.. The subject group consisted of 26 women aged 19-22 years. A nutritional assessment was performed using 3 day repeats of 24-hour recall interviews. A 9-point aMED (alternate Mediterranean Diet) score was used to study dietary habits. Serum beta-carotene was measured by liquid chromatography with photodiode array detection (HPLC-PDA).. Beta-carotene dietary intake was highly variable, ranging from 734 to 14476 microg/day (median 3022 microg/day). Serum beta-carotene concentration ranged between 0.071-1.905 micromol/L (median 0.519 micromol/L) and was significantly associated with the Mediterranean Diet model (Spearman r = 0.633, p < 0.001). Out of the dietary sources of beta-carotene, consuming carrots had the most significant impact on its serum concentration. Other dietary factors positively affecting serum beta-carotene were: consumption of nuts and seeds, pulses, a favourable ratio of mono-unsaturated fatty acids to saturated fatty acids and eating fruit and wholegrain cereal products.. Adopting a Mediterranean-based diet had a positive effect on increasing serum beta-carotene levels.

Topics: Antioxidants; beta Carotene; Chromatography, High Pressure Liquid; Diet, Mediterranean; Feeding Behavior; Female; Fruit; Humans; Metabolic Diseases; Nutritional Status; Poland; Vegetables; Women's Health; Young Adult

Carotenemia is a common benign pediatric condition of yellowing of the skin and elevated beta-carotene levels in the blood. The condition is usually caused by excessive beta-carotene intake but is also more rarely associated with a few serious metabolic disorders. Carotenemia caused by high beta-carotene intake does not have serious sequelae; discoloration remits with dietary modification.

Topics: beta Carotene; Diagnosis, Differential; Humans; Metabolic Diseases; Nutrition Disorders; Skin Diseases