beta-carotene and Diarrhea

Breath tests are quick, noninvasive, simple to perform and reliable. In particular in patients with diarrhea, bloating, nausea and uncharacteristic abdominal symptoms, the H2 breath test is highly useful. Using this procedure, malabsorption of various different carbohydrates, the absorptive performance of the upper abdominal tract, the orocecal transit time, or bacterial overgrowth in the small bowel, can be determined. Using 24-hour pH-metry, the acidity in the stomach and esophagus can be measured, and reflux disease, for example, diagnosed. Today, elevated fat in the stool is detected on the basis of the beta carotene level in the serum. Further function tests for the detection of pancreatic insufficiency, such as the determination of fecal pancreatic elastase, are also available.

Topics: beta Carotene; Breath Tests; Constipation; Diagnostic Techniques, Digestive System; Diarrhea; Esophageal pH Monitoring; Family Practice; Feces; Gastric Acidity Determination; Gastroesophageal Reflux; Gastrointestinal Diseases; Humans; Malabsorption Syndromes; Pancreatic Elastase; Pancreatic Function Tests

People with non-pathological diarrhoea-predominant irritable bowel syndrome (IBS-D)-like symptoms are present at a significant level even in healthy populations, but established prophylaxis is lacking. Previously, we have found that co-administration of Lactobacillus brevis KB290 (KB290) and β-carotene (βC) attenuated murine colitis (potential cause of IBS-D-like symptoms) significantly. Here, we investigated the effect of KB290 and βC on minor IBS-D-like symptoms in healthy volunteers. After a 4-week run-in period, subjects received a KB290 + βC or placebo capsule for 12 weeks, followed by a 4-week washout period. The KB290 + βC group showed a significant improvement in intensity of abdominal pain and stool frequency compared with the placebo group. The KB290 + βC group showed a significantly higher serum concentration of anti-inflammatory cytokine, interleukin-10, compared with the placebo group. In conclusion, we demonstrated that consumption of KB290 + βC improves minor IBS-D-like symptoms and inflammatory status in healthy volunteers. (UMIN000018002).

Topics: Abdominal Pain; Adult; beta Carotene; Defecation; Diarrhea; Double-Blind Method; Feces; Female; Humans; Irritable Bowel Syndrome; Levilactobacillus brevis; Male; Middle Aged; Probiotics; Young Adult

Ninety normal healthy adults were given 0, 8, 20 or 32 g/d olestra for 8 wk as part of a diet that provided 1 +/- 0.2 of the recommended dietary allowance (RDA) of vitamins A, D, E and K, folate zinc, calcium and iron. In addition, a 20 microg/d supplement of vitamin D was supplied. The diet provided 15% of energy from protein, 35% from fat and 55% from carbohydrate. The purpose of the study was to determine the dose response of olestra on vitamins D, E and K, carotenoids, vitamin B12, folate and zinc. Circulating concentrations of retinol, carotenoids, tocopherols, 25-hydroxy- and 1,25-dihydroxyvitamin D metabolites, phylloquinone, des-gamma-carboxyprothrombin, prothrombin, folate and hematological parameters were measured biweekly, as were urine concentrations of zinc and gamma-carboxyglutamic acid (Gla). Clinical chemistry, urinalysis and vitamin B12 absorption were measured at wk 0 and 8. Olestra reduced serum concentrations of carotenoids, alpha-tocopherol, 25-hydroxyergocalciferol and phylloquinone in a dose-responsive manner. Olestra did not affect Gla excretion, plasma des-gamma-carboxyprothrombin or prothrombin concentrations, prothrombin time, vitamin B12 absorption, overall vitamin D status or the status of folate or zinc. Laboratory evaluations showed no health-related effects of olestra. Subjects in all groups reported common gastrointestinal symptoms such as loose stools, fecal urgency and flatulence, which were transient and generally mild to moderate in severity. These symptoms did not affect protocol compliance or the ability to measure the potential for olestra to affect nutrient availability.

Topics: 25-Hydroxyvitamin D 2; Adult; beta Carotene; Calcifediol; Diarrhea; Dietary Fats, Unsaturated; Dose-Response Relationship, Drug; Double-Blind Method; Energy Intake; Fat Substitutes; Fatty Acids; Female; Folic Acid; Humans; Male; Nutritional Status; Sucrose; Vitamin D; Vitamin E; Vitamin K 1; Zinc

Many foals develop diarrhoea within the first two weeks of life which has been suggested to coincide with postpartum oestrus in their dams. To analyse the pathogenesis of this diarrhoea we have determined faecal bacteria in foals and their dams (n=30 each), and serum IGF-1 and γ-globulins for 6 weeks after birth. In addition, effects of β-carotene supplementation to mares (group 1: 1000 mg/day, n=15, group 2: control, n=15) on diarrhoea in foals were studied. Diarrhoea occurred in 92 and 79% of foals in groups 1 and 2, respectively, but was not correlated with oestrus in mares. Beta-carotene supplementation was without effect on foal diarrhoea. In mares, bacterial flora remained stable. The percentage of foals with cultures positive for E. coli was low at birth but increased within one day, the percentage positive for Enterococcus sp. was low for 10 days and for Streptococcus sp. and Staphylococcus sp. was low for 2-4 weeks. By 4 weeks of age, bacterial flora in foals resembled an adult pattern. Concentration of serum IGF-1 was low at birth (group 1: 149 ± 11, group 2: 166 ± 17ng/ml), increased after day 1 (day 7 group 1: 384 ± 30, group 2: 372 ± 36) but at no time differed between groups. Serum γ-globulin concentration in foals was low before colostrum intake and highest on day 1 (p<0.001 over time). In conclusion, neonatal diarrhoea in foals does not coincide with postpartum oestrus in their dams but with changes in intestinal bacteria and is not influenced by β-carotene supplementation given to mares.

Topics: Animal Feed; Animals; Animals, Newborn; Bacteria; beta Carotene; Diarrhea; Estrus; Feces; Female; gamma-Globulins; Horse Diseases; Horses; Insulin-Like Growth Factor I; Intestines; Pregnancy

Olestra is a zero-calorie fat replacement intended to replace 100% of the fat used in the preparation of savory snacks. Olestra can affect the absorption of other dietary components, especially highly lipophilic ones, when ingested at the same time. The potential effects of olestra on the absorption of essential fat-soluble and water-soluble dietary components have been investigated in pigs and in humans. In these studies, subjects were fed daily amounts of olestra up to 10 times the estimated mean intake from savory snacks and the olestra was eaten each day of the studies. In real life, snacks are eaten on average five times in a 14-d period. Olestra did not affect the availability of water-soluble micronutrients or the absorption and utilization of macronutrients. Olestra reduced the absorption of fat-soluble vitamins A, D, E and K; however, the effects can be offset by adding specified amounts of the vitamins to olestra foods. Olestra also reduced the absorption of carotenoids; analysis of dietary patterns showed that in real life the reduction will likely be <10%. Any effect on vitamin A stores caused by a reduction in carotenoid uptake is offset by the addition of vitamin A to olestra foods. Because of the olestra-to-nutrient ratios fed and the nutritional requirements of the test subjects, the effects of olestra on nutritional status of subgroups of the population are unlikely to be different than those measured in the studies. An analysis of lipophilicity showed that olestra is unlikely to significantly affect the uptake of potentially beneficial phytochemicals from fruits and vegetables. Some people eating large amounts of olestra snacks may experience common GI symptoms such as stomach discomfort or changes in stool consistency, similar to symptoms accompanying other dietary changes. These symptoms present no health risks.

Topics: Animals; beta Carotene; Biological Availability; Carotenoids; Diarrhea; Diet; Dietary Fats, Unsaturated; Fat Substitutes; Fatty Acids; Humans; Liver; Nutritional Status; Sucrose; Vitamin A; Vitamins

Deficiency of serum vitamin A is one of the widespread public health problem among pre-school children in developing countries. A limited number of studies have been done about this problem in Turkey and there is no similar work done in Malatya. Serum vitamin A and beta-carotene levels in 56 pre-school age children who had recurrent acute respiratory infections (ARI) or recurrent diarrhoea were determined by a UV/VIS spectrometer. The results obtained were compared with 35 healthy pre-school age children. Serum vitamin A (51.66 +/- 8.10 micrograms/dL) and beta-carotene (82.88 +/- 18.5 micrograms/dL) levels in children with ARI's were found significantly lower than the control group (58.14 +/- 9.07 micrograms/dL and 131.43 +/- 22.38 micrograms/dL, respectively) (P < 0.001). Serum vitamin A (47.21 +/- 8.27 micrograms/dL) and beta-carotene (81.63 +/- 15.41 micrograms/dL) levels in children with recurrent diarrhoea were also found significantly lower than the control group (58.14 +/- 9.07 micrograms/dL and 131.43 +/- 22.38 micrograms/dL, respectively) (P < 0.001).

Topics: Acute Disease; beta Carotene; Case-Control Studies; Child; Child, Preschool; Deficiency Diseases; Developing Countries; Diarrhea; Female; Humans; Incidence; Infant; Male; Recurrence; Respiratory Tract Infections; Turkey; Urban Population; Vitamin A; Vitamin A Deficiency