beta-carotene and Anemia--Aplastic

beta-carotene has been researched along with Anemia--Aplastic* in 2 studies

Other Studies

2 other study(ies) available for beta-carotene and Anemia--Aplastic

Article	Year
Plasma vitamin E and beta-carotene concentrations during radiochemotherapy preceding bone marrow transplantation. The American journal of clinical nutrition, 1990, Volume: 51, Issue:2 Blood from 19 patients was examined for the essential antioxidants alpha-tocopherol and beta-carotene before, during, and after bone marrow transplantation (BMT). Marrow ablation and immunosuppression for BMT conditioning was achieved by treatment with high-dose chemotherapy, mostly combined with total body irradiation. All patients required total parenteral nutrition beginning 1 wk before BMT. After conditioning therapy the concentration of absolute and lipid-standardized alpha-tocopherol and beta-carotene in plasma decreased significantly, presumably as a result of an enhanced breakdown of these antioxidants. The loss of these lipid-soluble antioxidants has to be considered as a possible cause for early posttransplant organ toxicity. Topics: Adolescent; Adult; Anemia, Aplastic; beta Carotene; Bone Marrow Transplantation; Carotenoids; Cholesterol; Combined Modality Therapy; Erythrocyte Membrane; Female; Humans; Leukemia; Male; Myelodysplastic Syndromes; Neuroblastoma; Vitamin E	1990
Effect of etoposide (VP16-213) on lipid peroxidation and antioxidant status in a high-dose radiochemotherapy regimen. Cancer chemotherapy and pharmacology, 1989, Volume: 25, Issue:3 A total of 13 patients receiving bone marrow transplants (BMT) for treatment of different haematological diseases were investigated. Conditioning therapy preceding BMT consisted of fractionated total-body irradiation (12 Gy) and high-dose chemotherapy with cyclophosphamide (2 +/- 60 mg/kg). Patients stratified to be at high risk for relapse (6/13) were additionally treated with etoposide (30 mg/kg). Plasma concentrations of absolute and lipid-standardized antioxidants (alpha-tocopherol and beta-carotene) decreased following conditioning therapy, presumably as the result of an enhanced breakdown of these antioxidants. Etoposide treatment did not amplify the loss of essential anti-oxidants but significantly increased lipid hydroperoxide concentrations in serum. We suggest that the abnormal generation of lipid hydroperoxides is the result of free radical formation. Topics: Anemia, Aplastic; Antioxidants; beta Carotene; Bone Marrow Transplantation; Carotenoids; Combined Modality Therapy; Etoposide; Humans; Leukemia; Lipid Peroxidation; Lipid Peroxides; Myelodysplastic Syndromes; Parenteral Nutrition; Radiotherapy Dosage; Time Factors; Vitamin E	1989

Article

Year

Plasma vitamin E and beta-carotene concentrations during radiochemotherapy preceding bone marrow transplantation.

The American journal of clinical nutrition, 1990, Volume: 51, Issue:2

Blood from 19 patients was examined for the essential antioxidants alpha-tocopherol and beta-carotene before, during, and after bone marrow transplantation (BMT). Marrow ablation and immunosuppression for BMT conditioning was achieved by treatment with high-dose chemotherapy, mostly combined with total body irradiation. All patients required total parenteral nutrition beginning 1 wk before BMT. After conditioning therapy the concentration of absolute and lipid-standardized alpha-tocopherol and beta-carotene in plasma decreased significantly, presumably as a result of an enhanced breakdown of these antioxidants. The loss of these lipid-soluble antioxidants has to be considered as a possible cause for early posttransplant organ toxicity.

Topics: Adolescent; Adult; Anemia, Aplastic; beta Carotene; Bone Marrow Transplantation; Carotenoids; Cholesterol; Combined Modality Therapy; Erythrocyte Membrane; Female; Humans; Leukemia; Male; Myelodysplastic Syndromes; Neuroblastoma; Vitamin E

1990

Effect of etoposide (VP16-213) on lipid peroxidation and antioxidant status in a high-dose radiochemotherapy regimen.

Cancer chemotherapy and pharmacology, 1989, Volume: 25, Issue:3

A total of 13 patients receiving bone marrow transplants (BMT) for treatment of different haematological diseases were investigated. Conditioning therapy preceding BMT consisted of fractionated total-body irradiation (12 Gy) and high-dose chemotherapy with cyclophosphamide (2 +/- 60 mg/kg). Patients stratified to be at high risk for relapse (6/13) were additionally treated with etoposide (30 mg/kg). Plasma concentrations of absolute and lipid-standardized antioxidants (alpha-tocopherol and beta-carotene) decreased following conditioning therapy, presumably as the result of an enhanced breakdown of these antioxidants. Etoposide treatment did not amplify the loss of essential anti-oxidants but significantly increased lipid hydroperoxide concentrations in serum. We suggest that the abnormal generation of lipid hydroperoxides is the result of free radical formation.

Topics: Anemia, Aplastic; Antioxidants; beta Carotene; Bone Marrow Transplantation; Carotenoids; Combined Modality Therapy; Etoposide; Humans; Leukemia; Lipid Peroxidation; Lipid Peroxides; Myelodysplastic Syndromes; Parenteral Nutrition; Radiotherapy Dosage; Time Factors; Vitamin E

1989