Compounds > beta-aminoethyl isothiourea
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beta-aminoethyl isothiourea and Marchiafava-Micheli Syndrome

beta-aminoethyl isothiourea has been researched along with Marchiafava-Micheli Syndrome in 21 studies

beta-Aminoethyl Isothiourea: A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.

Research Excerpts

ExcerptRelevanceReference
"The affected erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH II and PNH III cells) are abnormally sensitive to complement-mediated lysis."1.27Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes. ( Parker, CJ; Rosse, WF; Sims, PJ; Wiedmer, T, 1985)
"Both normal and HANE serum lysed paroxysmal nocturnal hemoglobinuria (PNH) cells when complement was activated by acidification, CoF and inulin, indicating that the terminal steps of complement were activated in the absence of C4, presumably by the alternate or properdin pathway."1.25Mechanisms of immune lysis of red blood cells in vitro. I. Paroxysmal nocturnal hemoglobinuria cells. ( Adams, JP; Logue, GL; Rosse, WF, 1973)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199020 (95.24)18.7374
1990's1 (4.76)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SIRCHIA, G10
FERRONE, S9
MERCURIALI, F4
Dacie, JV2
Falezza, GC1
Corrocher, R3
Olivieri, O1
Capra, F1
Trevisoi, E1
Pennacchioni, A1
De Sandre, G3
Advani, H1
Zamor, J1
Judd, WJ1
Johnson, CL1
Marsh, WL1
Burapakulsolsri, N1
Yuthavong, Y1
Wilairat, P1
Ezzell, JL1
Wilcox, LA1
Bernshaw, NJ1
Parker, CJ2
Wiedmer, T1
Sims, PJ1
Rosse, WF3
Guarini, L1
Bassetto, MA1
Rabusin, P1
Tedesco, F1
Jirillo, E1
Dierich, MP1
Pellegrino, MA1
Reisfeld, RA1
Lewis, SM2
Kabakçi, T1
Logue, GL2
Adams, JP1
Marubini, E2
Lambertenghi, G1
Canellos, GP1
Brain, MC1
Zanella, A1
D'Amico, G1
Romagnoni, M1

Reviews

2 reviews available for beta-aminoethyl isothiourea and Marchiafava-Micheli Syndrome

ArticleYear
The laboratory substitutes of the red cell of paroxysmal nocturnal haemoglobinuria (PNH): PNH-like red cells.
    Series haematologica (1968), 1972, Volume: 5, Issue:3

    Topics: beta-Aminoethyl Isothiourea; Cell Survival; Circadian Rhythm; Complement System Proteins; Cysteine;

1972
PNH: disease or defect?
    British journal of haematology, 1972, Volume: 23

    Topics: Adult; Anemia, Aplastic; Autoantibodies; beta-Aminoethyl Isothiourea; Blood Transfusion; Bone Marrow

1972

Other Studies

19 other studies available for beta-aminoethyl isothiourea and Marchiafava-Micheli Syndrome

ArticleYear
THE ACTION OF TWO SULFHYDRYL COMPOUNDS ON NORMAL HUMAN RED CELLS. RELATIONSHIP TO RED CELLS OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA.
    Blood, 1965, Volume: 25

    Topics: beta-Aminoethyl Isothiourea; Calcium; Cell Death; Complement System Proteins; Cysteine; Dextrans; Er

1965
Immune lysis of AET-treated normal red cells (PNH-like cells).
    Nature, 1967, Aug-12, Volume: 215, Issue:5102

    Topics: beta-Aminoethyl Isothiourea; Cell Membrane; Complement System Proteins; Cysteine; Erythrocytes; Hemo

1967
In vitro production of PNH-like red blood cells by 2-mercaptopropionylglycine.
    Acta haematologica, 1980, Volume: 64, Issue:6

    Topics: Acetylcholine; Acetylcholinesterase; Amino Acids, Sulfur; beta-Aminoethyl Isothiourea; Choline; Eryt

1980
Inactivation of Kell blood group antigens by 2-aminoethylisothiouronium bromide.
    British journal of haematology, 1982, Volume: 51, Issue:1

    Topics: beta-Aminoethyl Isothiourea; Blood Group Antigens; Erythrocytes; Hemoglobinuria, Paroxysmal; Humans;

1982
An examination of complement proteins on membranes of paroxysmal nocturnal haemoglobinuria (PNH) and PNH-like red cells.
    British journal of haematology, 1979, Volume: 41, Issue:3

    Topics: beta-Aminoethyl Isothiourea; Blood Protein Electrophoresis; Complement System Proteins; Erythrocyte

1979
Induction of the paroxysmal nocturnal hemoglobinuria phenotype in normal human erythrocytes: effects of 2-aminoethylisothiouronium bromide on membrane proteins that regulate complement.
    Blood, 1991, Jun-15, Volume: 77, Issue:12

    Topics: Antibodies; Antigens, Differentiation; beta-Aminoethyl Isothiourea; CD55 Antigens; CD59 Antigens; Co

1991
Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes.
    The Journal of clinical investigation, 1985, Volume: 75, Issue:6

    Topics: beta-Aminoethyl Isothiourea; Cobra Cardiotoxin Proteins; Complement Activation; Complement C3; Compl

1985
[Modifications of membrane antigen reactivity in PNH-like erythrocytes (author's transl)].
    Haematologica, 1974, Volume: 59, Issue:1

    Topics: ABO Blood-Group System; beta-Aminoethyl Isothiourea; Blood Group Antigens; Cell Membrane; Coombs Tes

1974
Reactive haemolysis test in paroxysmal nocturnal haemoglobinuria.
    Haematologica, 1974, Volume: 59, Issue:3

    Topics: Acids; beta-Aminoethyl Isothiourea; Complement System Proteins; Erythrocytes; Hemoglobinuria, Paroxy

1974
Chemical modulation of cell surfaces by sulfhydryl compounds: effect on C3b receptors.
    Journal of immunology (Baltimore, Md. : 1950), 1974, Volume: 113, Issue:3

    Topics: ABO Blood-Group System; Acetamides; Animals; beta-Aminoethyl Isothiourea; Binding Sites, Antibody; C

1974
The lysis of paroxysmal nocturnal haemoglobinuria red cells by serum and cobra factor.
    British journal of haematology, 1972, Volume: 23, Issue:6

    Topics: Animals; beta-Aminoethyl Isothiourea; Complement System Proteins; Edetic Acid; Erythrocytes; Glutath

1972
Mechanisms of immune lysis of red blood cells in vitro. I. Paroxysmal nocturnal hemoglobinuria cells.
    The Journal of clinical investigation, 1973, Volume: 52, Issue:5

    Topics: Angioedema; beta-Aminoethyl Isothiourea; Binding Sites; Cell Membrane; Cells, Cultured; Complement F

1973
Study of two in vitro diagnostic tests for paroxysmal nocturnal haemoglobinuria.
    British journal of haematology, 1973, Volume: 24, Issue:6

    Topics: Analysis of Variance; beta-Aminoethyl Isothiourea; Circadian Rhythm; Erythrocytes; Hemoglobinuria, P

1973
In-vitro lysis of AET-treated normal red cells (PNH-like cells) by normal and cirrhotic sera.
    British journal of haematology, 1969, Volume: 17, Issue:3

    Topics: beta-Aminoethyl Isothiourea; Complement System Proteins; Erythrocytes; Hemoglobinuria, Paroxysmal; H

1969
Study of in vitro lysis of paroxysmal nocturnal haemoglobinuria (PNH) and PNH-like red cells.
    British journal of haematology, 1972, Volume: 23, Issue:1

    Topics: beta-Aminoethyl Isothiourea; Complement System Proteins; Erythrocytes; Erythrocytes, Abnormal; Hemog

1972
Electron microscope study of PNH red cells and AET-treated normal red cells (PNH-like cells).
    Journal of clinical pathology, 1971, Volume: 24, Issue:8

    Topics: beta-Aminoethyl Isothiourea; Cell Membrane; Erythrocytes; Erythrocytes, Abnormal; Hemoglobinuria, Pa

1971
Effects of sulphydryl inhibition on the erythrocyte in paroxysmal nocturnal haemoglobinuria.
    British journal of haematology, 1970, Volume: 18, Issue:3

    Topics: Adult; Aged; beta-Aminoethyl Isothiourea; Cell Membrane; Chloromercuribenzoates; Erythrocytes; Femal

1970
Study of the acetylcholinesterase activity of AET-treated (2-aminoethylisothiouronium bromide) normal red cells (PNH-like cells).
    Acta vitaminologica et enzymologica, 1970, Volume: 24, Issue:6

    Topics: Acetylcholinesterase; beta-Aminoethyl Isothiourea; Complement System Proteins; Enzyme Repression; Er

1970
Cation transport in normal human red cells treated with sulfhydryl compounds.
    Experientia, 1966, Jan-15, Volume: 22, Issue:1

    Topics: beta-Aminoethyl Isothiourea; Biological Transport, Active; Cysteine; Erythrocytes; Hemoglobinuria, P

1966