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beta-alanine and Lathyrism

beta-alanine has been researched along with Lathyrism in 14 studies

Lathyrism: A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS.

Research Excerpts

ExcerptRelevanceReference
"beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) are chemically related excitant amino acids isolated from the seed of Lathyrus sativus (BOAA) and Cycas circinalis (BMAA), consumption of which has been linked to lathyrism (an upper motor neuron disorder) and Guam amyotrophic lateral sclerosis (ALS), respectively."3.67Discovery and partial characterization of primate motor-system toxins. ( Hugon, J; Ludolph, A; Nunn, PB; Ross, SM; Roy, DN; Schaumburg, HH; Spencer, PS, 1987)
"Neurolathyrism, konzo, and amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS-PDC) have attracted researchers to study the pathology of motor neuron (MN) diseases such as ALS."2.61[Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism]. ( Kusama-Eguchi, K, 2019)
"sativus there is reduction in lathyrism cases where higher consumption of L."1.48Current scenario of consumption of Lathyrus sativus and lathyrism in three districts of Chhattisgarh State, India. ( Arlappa, N; Khandare, AL; Kumar, RH; Laxmaiah, A; Meshram, II; Rao, PA; Toteja, GS; Validandi, V; Venkaiah, K, 2018)
"Neurolathyrism is a motor neuron (MN) disease caused by β-N-oxalyl-L-α,β-diaminopropionic acid (L-β-ODAP), an AMPA receptor agonist."1.40New insights into the mechanism of neurolathyrism: L-β-ODAP triggers [Ca2+]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors. ( Ikegami, F; Ishige, K; Ishii, M; Ito, Y; Kusama, T; Kusama-Eguchi, K; Miyano, T; Ogawa, Y; Suda, A; Watanabe, K; Yamamoto, M, 2014)
"Neurolathyrism (NL) is a motor neuron disease characterized by spastic paraparesis in the hind legs."1.38Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis. ( Kawaguchi, K; Kusama-Eguchi, K; Lambein, F, 2012)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19904 (28.57)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Khandare, AL1
Kumar, RH1
Meshram, II1
Arlappa, N1
Laxmaiah, A1
Venkaiah, K1
Rao, PA1
Validandi, V1
Toteja, GS1
Kusama-Eguchi, K4
Miyano, T1
Yamamoto, M1
Suda, A2
Ito, Y1
Ishige, K1
Ishii, M1
Ogawa, Y2
Watanabe, K2
Ikegami, F2
Kusama, T2
Sacristán, M1
Varela, A1
Pedrosa, MM1
Burbano, C1
Cuadrado, C1
Legaz, ME1
Muzquiz, M1
Barceloux, DG1
Van Moorhem, M1
Decrock, E1
De Vuyst, E1
De Bock, M1
Wang, N1
Lambein, F2
Van Den Bosch, L1
Leybaert, L1
Kawaguchi, K1
RAO, SL1
ADIGA, PR1
SARMA, PS1
Igarashi, K1
Ravindranath, V1
Spencer, PS4
Allen, CN1
Kisby, GE1
Ludolph, AC1
Ross, SM3
Roy, DN4
Ludolph, A2
Hugon, J2
Dwivedi, MP1
Schaumburg, HH2
Nunn, PB2
Seelig, M1

Reviews

4 reviews available for beta-alanine and Lathyrism

ArticleYear
[Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Volume: 139, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta-Alanine; Cell Death; Disease

2019
Grass pea and neurolathyrism (Lathyrus sativus L.).
    Disease-a-month : DM, 2009, Volume: 55, Issue:6

    Topics: Animals; beta-Alanine; Foodborne Diseases; Humans; Lathyrism; Lathyrus

2009
Neurolathyrism: mitochondrial dysfunction in excitotoxicity mediated by L-beta-oxalyl aminoalanine.
    Neurochemistry international, 2002, Volume: 40, Issue:6

    Topics: Amino Acids, Diamino; Animals; beta-Alanine; Brain; Brain Chemistry; Calcium; Excitatory Amino Acids

2002
Lathyrism and western Pacific amyotrophic lateral sclerosis: etiology of short and long latency motor system disorders.
    Advances in neurology, 1991, Volume: 56

    Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; beta-Alanine; Humans; Lathyrism; Nerve Degenera

1991

Other Studies

10 other studies available for beta-alanine and Lathyrism

ArticleYear
Current scenario of consumption of Lathyrus sativus and lathyrism in three districts of Chhattisgarh State, India.
    Toxicon : official journal of the International Society on Toxinology, 2018, Volume: 150

    Topics: Amino Acids; beta-Alanine; Diet Surveys; Humans; India; Lathyrism; Lathyrus; Plant Proteins; Rural P

2018
New insights into the mechanism of neurolathyrism: L-β-ODAP triggers [Ca2+]i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2014, Volume: 67

    Topics: Animals; beta-Alanine; Calcium; Cell Death; Female; Lathyrism; Motor Neurons; Pregnancy; Rats; Rats,

2014
Determination of β-N-oxalyl-L-α,β-diaminopropionic acid and homoarginine in Lathyrus sativus and Lathyrus cicera by capillary zone electrophoresis.
    Journal of the science of food and agriculture, 2015, Volume: 95, Issue:7

    Topics: Animals; beta-Alanine; Diet; Dietary Proteins; Electrophoresis, Capillary; Homoarginine; Humans; Lat

2015
L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons.
    Neuroreport, 2011, Feb-16, Volume: 22, Issue:3

    Topics: Animals; beta-Alanine; Cells, Cultured; Lathyrism; Motor Neuron Disease; Motor Neurons; Nerve Degene

2011
Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis.
    Biochemical and biophysical research communications, 2012, Nov-09, Volume: 428, Issue:1

    Topics: Animals; beta-Alanine; Blood Vessels; Disease Models, Animal; Heme Oxygenase-1; Hemorrhage; Human Um

2012
THE ISOLATION AND CHARACTERIZATION OF BETA-N-OXALYL-L-ALPHA,BETA-DIAMINOPROPIONIC ACID: A NEUROTOXIN FROM THE SEEDS OF LATHYRUS SATIVUS.
    Biochemistry, 1964, Volume: 3

    Topics: Animals; Antitoxins; beta-Alanine; Candida; Chromatography; Escherichia coli; Infrared Rays; Insecta

1964
A rat model of neurolathyrism: repeated injection of L: -beta-ODAP induces the paraparesis of the hind legs.
    Amino acids, 2005, Volume: 28, Issue:2

    Topics: Animals; Animals, Newborn; beta-Alanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Inf

2005
Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.
    Lancet (London, England), 1986, Nov-08, Volume: 2, Issue:8515

    Topics: Adolescent; Adult; Alanine; Amino Acids, Diamino; Animals; beta-Alanine; Central Nervous System; Chi

1986
Discovery and partial characterization of primate motor-system toxins.
    Ciba Foundation symposium, 1987, Volume: 126

    Topics: Alanine; Amino Acids, Diamino; Animals; beta-Alanine; Cyanobacteria Toxins; Humans; Lathyrism; Macac

1987
Detection and characterization of plant-derived amino acid motorsystem toxins in mouse CNS cultures.
    Progress in clinical and biological research, 1987, Volume: 253

    Topics: Alanine; Amino Acids, Diamino; Animals; beta-Alanine; Cell Survival; Cells, Cultured; Central Nervou

1987