Page last updated: 2024-10-16

beta-alanine and Glaucoma, Suspect

beta-alanine has been researched along with Glaucoma, Suspect in 33 studies

Research Excerpts

ExcerptRelevanceReference
"To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID)."9.30Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study. ( Bacharach, J; Braswell, P; Heah, T; Khouri, AS; Kopczynski, CC; Lewis, RA; Serle, JB; Usner, DW, 2019)
"Adults with open-angle glaucoma or ocular hypertension (unmedicated intraocular pressure [IOP] >20 and <36 mm Hg at 8:00 AM) were randomized to receive once-daily netarsudil/latanoprost FDC, netarsudil 0."9.30Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial. ( Asrani, S; Heah, T; Kopczynski, CC; Lewis, RA; Robin, AL; Serle, JB; Usner, DW, 2019)
" In this study, we conducted a systematic literature review and meta-analysis to summarize and synthesize the available evidence on the efficacy and safety of fixed-dose combination (FDC) therapy with netarsudil/latanoprost in patients with glaucoma."9.22Comparison of Netarsudil/Latanoprost Therapy with Latanoprost Monotherapy for Lowering Intraocular Pressure: A Systematic Review and Meta-analysis. ( Ahn, HS; Chang, DJ; Chang, J; Kang, HY; Lee, H; Lee, JW; Suh, JK, 2022)
" The objective of this 28-day study was to evaluate the ocular hypotensive efficacy and safety of AR-13324 ophthalmic solution compared with a positive control, latanoprost ophthalmic solution, in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT)."9.20Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure. ( Bacharach, J; Dubiner, HB; Kopczynski, CC; Levy, B; Novack, GD, 2015)
"New open-angle glaucoma (OAG) and ocular hypertension (OHT) therapies that reduce treatment burden and improve outcomes relative to currently available agents are needed."6.94Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2. ( Asrani, S; Bacharach, J; Heah, T; Holland, E; Kopczynski, CC; Lewis, RA; McKee, H; Sheng, H, 2020)
" The most frequent adverse event was conjunctival hyperemia, the incidence of which ranged from 50% (126/251, ROCKET-2) to 53% (108/203, ROCKET-1) for netarsudil q."6.87Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2). ( Heah, T; Katz, LJ; Kopczynski, CC; McLaurin, E; Novack, GD; Ramirez-Davis, N; Serle, JB; Usner, DW, 2018)
"Initial treatment of glaucoma commonly involves using anti-glaucoma medications either as monotherapy or combination therapy."6.66New glaucoma medications: latanoprostene bunod, netarsudil, and fixed combination netarsudil-latanoprost. ( Mehran, NA; Razeghinejad, R; Sinha, S, 2020)
"02% resulted in intraocular pressure (IOP) reduction that was noninferior to twice-daily timolol 0."5.34Pooled Efficacy and Safety Profile of Netarsudil Ophthalmic Solution 0.02% in Patients With Open-angle Glaucoma or Ocular Hypertension. ( Fechtner, RD; Heah, T; Kim, T; Kopczynski, CC; Lewis, RA; McKee, H; Myers, JS; Sheng, H; Singh, IP; Usner, DW, 2020)
"To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil once daily (QD) and timolol twice daily (BID)."5.30Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study. ( Bacharach, J; Braswell, P; Heah, T; Khouri, AS; Kopczynski, CC; Lewis, RA; Serle, JB; Usner, DW, 2019)
"Adults with open-angle glaucoma or ocular hypertension (unmedicated intraocular pressure [IOP] >20 and <36 mm Hg at 8:00 AM) were randomized to receive once-daily netarsudil/latanoprost FDC, netarsudil 0."5.30Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial. ( Asrani, S; Heah, T; Kopczynski, CC; Lewis, RA; Robin, AL; Serle, JB; Usner, DW, 2019)
" In this study, we conducted a systematic literature review and meta-analysis to summarize and synthesize the available evidence on the efficacy and safety of fixed-dose combination (FDC) therapy with netarsudil/latanoprost in patients with glaucoma."5.22Comparison of Netarsudil/Latanoprost Therapy with Latanoprost Monotherapy for Lowering Intraocular Pressure: A Systematic Review and Meta-analysis. ( Ahn, HS; Chang, DJ; Chang, J; Kang, HY; Lee, H; Lee, JW; Suh, JK, 2022)
" The objective of this 28-day study was to evaluate the ocular hypotensive efficacy and safety of AR-13324 ophthalmic solution compared with a positive control, latanoprost ophthalmic solution, in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT)."5.20Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure. ( Bacharach, J; Dubiner, HB; Kopczynski, CC; Levy, B; Novack, GD, 2015)
"Pharmacotherapies for POAG or ocular hypertension (OHT) commonly lower IOP by increasing uveoscleral outflow or decreasing aqueous humor production."3.01Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study. ( Challa, P; Gupta, D; Heah, T; Kazemi, A; Kopczynski, C; Liu, KC; Lopez, J; McKee, H; Sit, AJ, 2021)
"04% dosed QD (P."3.01Phase 2 Randomized Clinical Study of Netarsudil Ophthalmic Solution in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension. ( Araie, M; Aso, K; Hollander, DA; Kanemoto, K; Kopczynski, C; Kothapalli, K; Senchyna, M; Sugiyama, K, 2021)
"New open-angle glaucoma (OAG) and ocular hypertension (OHT) therapies that reduce treatment burden and improve outcomes relative to currently available agents are needed."2.94Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2. ( Asrani, S; Bacharach, J; Heah, T; Holland, E; Kopczynski, CC; Lewis, RA; McKee, H; Sheng, H, 2020)
" The most frequently reported adverse events (AEs) were ocular, with the most frequent ocular AE being conjunctival hyperemia, with an incidence of 61%, 66%, and 14%, respectively."2.90Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2). ( Heah, T; Kahook, MY; Kim, T; Kopczynski, CC; Mah, FS; Novack, GD; Raizman, MB; Ramirez-Davis, N; Serle, JB; Usner, DW, 2019)
" The most frequent adverse event was conjunctival hyperemia, the incidence of which ranged from 50% (126/251, ROCKET-2) to 53% (108/203, ROCKET-1) for netarsudil q."2.87Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2). ( Heah, T; Katz, LJ; Kopczynski, CC; McLaurin, E; Novack, GD; Ramirez-Davis, N; Serle, JB; Usner, DW, 2018)
"Elevated intraocular pressure is a prime risk factor for blindness in the elderly."2.72Netarsudil: A new ophthalmic drug in the treatment of chronic primary open angle glaucoma and ocular hypertension. ( Batra, M; Dhanawat, M; Gupta, S; Morsy, MA; Nair, AB; Sandal, S, 2021)
"Initial treatment of glaucoma commonly involves using anti-glaucoma medications either as monotherapy or combination therapy."2.66New glaucoma medications: latanoprostene bunod, netarsudil, and fixed combination netarsudil-latanoprost. ( Mehran, NA; Razeghinejad, R; Sinha, S, 2020)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (30.30)24.3611
2020's23 (69.70)2.80

Authors

AuthorsStudies
Shiuey, EJ1
Mehran, NA2
Ustaoglu, M1
Zhang, Q1
Razeghinejad, R3
Shukla, AG1
Kolomeyer, NN2
Myers, JS3
Lee, D2
Chen, YH1
Lin, WY1
Huang, YC1
Ho, WY1
Fu, CW1
Tu, CM1
Hwang, CS1
Hung, CL1
Lin, MC1
Cheng, F1
Wang, YJ1
Chen, CH1
Chou, SH1
She, MP1
Yang, CY1
Cheng, HL1
Liu, CP1
Lu, DW1
Lyons, LJ1
Wu, KY1
Baratz, KH1
Sit, AJ2
Bronner, AW1
Goergen, NS1
Gagrani, M1
Gulati, V1
Ghate, D1
Lee, JW1
Ahn, HS1
Chang, J1
Kang, HY1
Chang, DJ1
Suh, JK1
Lee, H1
Rivera, SS1
Radunzel, N1
Boese, EA1
Bonardi, A1
Supuran, CT1
Radell, JE1
Serle, JB5
Sinha, S2
Wisely, CE1
Sheng, H3
Heah, T9
Kim, T3
Asrani, S2
Bacharach, J3
Holland, E1
McKee, H3
Lewis, RA5
Kopczynski, CC9
Moumneh, K1
Sheybani, A1
Fellman, RL1
Godfrey, DG1
Grover, DS1
Singh, IP1
Fechtner, RD1
Usner, DW6
Price, MO1
Feng, MT1
Price, FW1
Gonzalez, LE1
Boylan, PM1
Gupta, D1
Kazemi, A1
Challa, P2
Liu, KC1
Lopez, J1
Kopczynski, C3
Araie, M1
Sugiyama, K1
Aso, K1
Kanemoto, K1
Kothapalli, K1
Senchyna, M1
Hollander, DA1
Mehta, AA1
Kanu, LN1
Sood-Mendiratta, S1
Quinones, R1
Hawkins, A1
Lehrer, RA1
Malhotra, K1
Papas, R1
Hillman, D1
Wilensky, JT1
Aref, AA1
Vajaranant, TS1
Edward, DP1
Zaman, F1
Gieser, SC1
Schwartz, GF1
Swan, C1
Williams, JM1
Li, G1
Lee, C1
Read, AT1
Wang, K1
Ha, J1
Kuhn, M1
Navarro, I1
Cui, J1
Young, K1
Gorijavolu, R1
Sulchek, T1
Farsiu, S1
Samples, J1
Ethier, CR1
Stamer, WD1
Batra, M1
Gupta, S1
Nair, AB1
Dhanawat, M1
Sandal, S1
Morsy, MA1
Kim, HM1
Tran, AQ1
Yang, C1
Dagi Glass, LR1
Leary, KA1
Steibel, JP1
Harman, CD1
Anderson, AL1
Komáromy, AM1
Katz, LJ1
McLaurin, E1
Ramirez-Davis, N2
Novack, GD4
Tanna, AP1
Johnson, M1
Kahook, MY1
Mah, FS1
Raizman, MB1
Khouri, AS1
Braswell, P1
Robin, AL1
Dubiner, HB1
Levy, B2
Ramirez, N1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Double-masked, Randomized, Multi-center, Active Controlled, Parallel-group, 3-month Study Assessing the Safety and Ocular Hypotensive Efficacy of PG324 Ophthalmic Solution Compared to AR-13324 Ophthalmic Solution 0.02% and Latanoprost Ophth[NCT02674854]Phase 3750 participants (Actual)Interventional2016-02-29Completed
A Prospective, Double-masked, Randomized, Multi-center, Active-controlled, Parallel-group 12-month Study Assessing the Safety and Ocular Hypotensive Efficacy of PG324 Ophthalmic Solution Compared to AR-13324 Ophthalmic Solution, 0.02% and Latanoprost Opht[NCT02558400]Phase 3718 participants (Actual)Interventional2015-09-18Completed
Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Primary Rhegmatogenous Detachments and Retinal Detachment Due to Proliferative Vitreoretinopathy or Open-Globe Injury: A Phase I/II Clinical Trial[NCT06033703]Phase 1/Phase 248 participants (Anticipated)Interventional2023-10-31Not yet recruiting
Randomized, Double-masked, Placebo-controlled Evaluation of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation[NCT03248037]Phase 3120 participants (Actual)Interventional2017-09-05Completed
A Prospective, Double-masked, Randomized, Multicenter, Placebo-controlled, Parallel-group Study Assessing the Safety, Ocular Hypotensive Efficacy and Optimum Dose Concentration to be Used Clinically of Netarsudil Ophthalmic Solution in Subjects With Open-[NCT03844945]Phase 2215 participants (Actual)Interventional2019-03-19Completed
A Multicenter, Open-label Study of Rhopressa® (Netarsudil Ophthalmic Solution) 0.02% for the Reduction of Elevated Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension in a Real-world Setting[NCT03808688]Phase 4261 participants (Actual)Interventional2018-12-27Completed
A Double-masked, Randomized, Controlled Study Assessing the Safety and Ocular Hypotensive Efficacy of PG324 Ophthalmic Solution, 0.01% and PG324 Ophthalmic Solution, 0.02%, Compared to AR-13324 Ophthalmic Solution, 0.02% and Latanoprost Ophthalmic Solutio[NCT02057575]Phase 2298 participants (Actual)Interventional2014-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Intraocular Pressure (IOP)

Mean intraocular pressure(IOP) at 08:00, 10:00 and 16:00 hours, at Day 15, Day 43 and Day 90, as measured by Goldmann applanation tonometry. (NCT02674854)
Timeframe: 3 months

,,
InterventionmmHg (Mean)
Day 1, 0800 hoursDay 1, 1000 hoursDay 1, 1600 hoursDay 15, 0800 hoursDay 15, 1000 hoursDay 15, 1600 hoursDay 43, 0800 hoursDay 43, 1000 hoursDay 43, 1600 hoursDay 90, 0800 hoursDay 90, 1000 hoursDay 90, 1600 hours
Latanoprost Ophthalmic Solution 0.005%24.7523.2322.5918.1017.6117.0817.9317.3517.0917.9817.4817.14
Netarsudil (AR-13324) Ophthalmic Solution 0.02%24.6623.4022.7619.3517.9917.5319.5218.4017.9519.7218.3017.94
PG324 Ophthalmic Solution24.6923.3322.3716.0615.3115.1616.4315.5415.4516.4515.5815.52

Extent of Exposure

Exposure to study medication in days for all treatment groups (NCT02558400)
Timeframe: 12 months

Interventiondays (Mean)
PG324 Ophthalmic Solution 0.02%/0.005%275.7
AR-13324 Ophthalmic Solution 0.02%266.2
Latanoprost Ophthalmic Solution 0.005%330.4

Intraocular Pressure (IOP)

The primary efficacy variable was mean IOP at 08:00, 10:00 and 16:00 hours at Day 15, Day 43 and Day 90, as measured by Goldmann applanation tonometry. Secondary analysis were conducted as a part of safety measurements to month 12 on treatment. (NCT02558400)
Timeframe: Primary efficacy endpoint measured for 3 months (data collected at 08:00, 10:00 and 16:00 hours at Day 15, Day 43 and Day 90)

,,
InterventionmmHg (Mean)
Day 1, 0800 hoursDay 1, 1000 hoursDay 1, 1600 hoursDay 15, 0800 hoursDay 15, 1000 hoursDay 15, 1600 hoursDay 43, 0800 hoursDay 43, 1000 hoursDay 43, 1600 hoursDay 90, 0800 hoursDay 90, 1000 hoursDay 90, 1600 hours
AR-13324 Ophthalmic Solution 0.02%24.8123.4522.6318.6617.7817.2519.0617.9217.5419.0417.9617.30
Latanoprost Ophthalmic Solution 0.005%24.5923.4323.4317.7417.3617.1117.5817.0616.9717.5316.8816.67
PG324 Ophthalmic Solution24.8423.7222.5915.6814.9314.8316.0415.3915.4316.3715.4115.49

Intraocular Pressure

Intraocular pressure measurement exceeding 24 mm Hg or more than 10 mm Hg greater than the pre-randomization reading. (NCT03248037)
Timeframe: from date of randomization until the date of first documented intraocular pressure elevation exceeding defined threshold up to 9 months

InterventionParticipants (Count of Participants)
Netarsudil11
Placebo18

Intraocular Pressure (IOP)

Mean diurnal IOP within a treatment by Goldman Applanation Tonometry (NCT03844945)
Timeframe: 29 Days

,,,
InterventionmmHg (Mean)
Day 1Day 8Day 15Day 29
Netarsudil Ophthalmic Solution 0.01%20.516.215.916.3
Netarsudil Ophthalmic Solution 0.02%20.315.915.615.4
Netarsudil Ophthalmic Solution 0.04%20.815.715.716.2
Netarsudil Ophthalmic Solution Placebo21.119.819.319.3

Intraocular Pressure (IOP)

"Percent Change from Baseline IOP at Week 12, as measured by Goldmann applanation tonometry.~Prostaglandin analog (PGA). Fixed dose combination (FDC)." (NCT03808688)
Timeframe: 12 weeks

Interventionpercent change (Mean)
Netarsudil Ophth Sol 0.02% Monotherapy - Tx Naïve At Baseline-16.9
Netarsudil Ophth Sol 0.02% Monotherapy - Replaced 1 Agent-2.3
Netarsudil Ophth Sol 0.02% Monotherapy - Replaced 2 Agents0.2
Netarsudil Ophth Sol 0.02% Concomitant Therapy-17.0

Intraocular Pressure (IOP)

The primary efficacy endpoint was the mean diurnal IOP across subjects within treatment group at Day 29. (NCT02057575)
Timeframe: Study treatment was administered for 28 days, and outcome measures collected on Day 29

,,,
InterventionmmHg (Mean)
Day 1, Diurnal MeanDay 29, Diurnal Mean
Latanoprost Ophthalmic Solution25.9918.44
Netarsudil (AR-13324) Ophthalmic Solution25.3519.13
PG324 Ophthalmic Solution 0.01%25.1117.33
PG324 Ophthalmic Solution 0.02%25.1216.52

Reviews

8 reviews available for beta-alanine and Glaucoma, Suspect

ArticleYear
Honeycomb Epithelial Edema Associated With Rho Kinase Inhibition: A Case Series and Review of the Literature.
    Cornea, 2022, Feb-01, Volume: 41, Issue:2

    Topics: Benzoates; beta-Alanine; Corneal Edema; Epithelium, Corneal; Humans; Intraocular Pressure; Ocular Hy

2022
Comparison of Netarsudil/Latanoprost Therapy with Latanoprost Monotherapy for Lowering Intraocular Pressure: A Systematic Review and Meta-analysis.
    Korean journal of ophthalmology : KJO, 2022, Volume: 36, Issue:5

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocula

2022
Fixed combination netarsudil-latanoprost for the treatment of glaucoma and ocular hypertension.
    Expert opinion on pharmacotherapy, 2020, Volume: 21, Issue:1

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Drug Combinations; Female; Glaucoma; Humans; Intra

2020
New glaucoma medications: latanoprostene bunod, netarsudil, and fixed combination netarsudil-latanoprost.
    Eye (London, England), 2020, Volume: 34, Issue:1

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocula

2020
Netarsudil for the Treatment of Open-Angle Glaucoma and Ocular Hypertension: A Literature Review.
    The Annals of pharmacotherapy, 2021, Volume: 55, Issue:8

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Glaucoma, Open-Angle; Humans; Intraocular Pressure

2021
Netarsudil: A new ophthalmic drug in the treatment of chronic primary open angle glaucoma and ocular hypertension.
    European journal of ophthalmology, 2021, Volume: 31, Issue:5

    Topics: Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Glaucoma, Open-Angle; Humans; Intraocular Pr

2021
Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension.
    Ophthalmology, 2018, Volume: 125, Issue:11

    Topics: Antihypertensive Agents; Aqueous Humor; Benzoates; beta-Alanine; Glaucoma, Open-Angle; Humans; Intra

2018
Netarsudil ophthalmic solution 0.02% for the treatment of patients with open-angle glaucoma or ocular hypertension.
    Drugs of today (Barcelona, Spain : 1998), 2018, Volume: 54, Issue:8

    Topics: Administration, Ophthalmic; Animals; Benzoates; beta-Alanine; Drug Interactions; Eye; Glaucoma, Open

2018

Trials

13 trials available for beta-alanine and Glaucoma, Suspect

ArticleYear
Effects of Netarsudil and Latanoprost Alone and in Fixed Combination on Corneal Endothelium and Corneal Thickness: Post-Hoc Analysis of MERCURY-2.
    Advances in therapy, 2020, Volume: 37, Issue:3

    Topics: Aged; Benzoates; beta-Alanine; Double-Blind Method; Drug Combinations; Endothelium, Corneal; Female;

2020
Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2.
    Advances in therapy, 2020, Volume: 37, Issue:4

    Topics: Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Female; Glaucoma, Open-Angle; Humans; Intrao

2020
Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2.
    Advances in therapy, 2020, Volume: 37, Issue:4

    Topics: Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Female; Glaucoma, Open-Angle; Humans; Intrao

2020
Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2.
    Advances in therapy, 2020, Volume: 37, Issue:4

    Topics: Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Female; Glaucoma, Open-Angle; Humans; Intrao

2020
Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2.
    Advances in therapy, 2020, Volume: 37, Issue:4

    Topics: Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Female; Glaucoma, Open-Angle; Humans; Intrao

2020
Pooled Efficacy and Safety Profile of Netarsudil Ophthalmic Solution 0.02% in Patients With Open-angle Glaucoma or Ocular Hypertension.
    Journal of glaucoma, 2020, Volume: 29, Issue:10

    Topics: Administration, Ophthalmic; Adult; Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Double-Bl

2020
Randomized, Double-Masked Trial of Netarsudil 0.02% Ophthalmic Solution for Prevention of Corticosteroid-Induced Ocular Hypertension.
    American journal of ophthalmology, 2021, Volume: 222

    Topics: Adult; Aged; Aged, 80 and over; Benzoates; beta-Alanine; Double-Blind Method; Female; Follow-Up Stud

2021
Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.
    American journal of ophthalmology, 2021, Volume: 226

    Topics: Administration, Ophthalmic; Adult; Aged; Aqueous Humor; Benzoates; beta-Alanine; Double-Blind Method

2021
Phase 2 Randomized Clinical Study of Netarsudil Ophthalmic Solution in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension.
    Advances in therapy, 2021, Volume: 38, Issue:4

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Double-Blind Method; Glaucoma, Open-Angle; Humans;

2021
A multicenter, open-label study of netarsudil for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension in a real-world setting.
    Current medical research and opinion, 2021, Volume: 37, Issue:6

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Glaucoma, Open-Angle; Humans; Intraocular Pressure

2021
Two Phase 3 Clinical Trials Comparing the Safety and Efficacy of Netarsudil to Timolol in Patients With Elevated Intraocular Pressure: Rho Kinase Elevated IOP Treatment Trial 1 and 2 (ROCKET-1 and ROCKET-2).
    American journal of ophthalmology, 2018, Volume: 186

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Benzoates; beta-Alanine; Child;

2018
Long-term Safety and Ocular Hypotensive Efficacy Evaluation of Netarsudil Ophthalmic Solution: Rho Kinase Elevated IOP Treatment Trial (ROCKET-2).
    American journal of ophthalmology, 2019, Volume: 200

    Topics: Administration, Ophthalmic; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Benzo

2019
Once-Daily Netarsudil Versus Twice-Daily Timolol in Patients With Elevated Intraocular Pressure: The Randomized Phase 3 ROCKET-4 Study.
    American journal of ophthalmology, 2019, Volume: 204

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Benzoates; beta-Alanine; Dose-Response Rela

2019
Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial.
    American journal of ophthalmology, 2019, Volume: 207

    Topics: Administration, Ophthalmic; Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Double-Blind Met

2019
Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure.
    Ophthalmology, 2015, Volume: 122, Issue:2

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Benzoates; beta-Al

2015
Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension.
    The British journal of ophthalmology, 2016, Volume: 100, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Benzoates; beta-Alanine; Corneal Pachymetry

2016

Other Studies

12 other studies available for beta-alanine and Glaucoma, Suspect

ArticleYear
The effectiveness and safety profile of netarsudil 0.02% in glaucoma treatment: real-world 6-month outcomes.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022, Volume: 260, Issue:3

    Topics: Aged; Aged, 80 and over; Benzoates; beta-Alanine; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocula

2022
The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models.
    Investigative ophthalmology & visual science, 2021, 10-04, Volume: 62, Issue:13

    Topics: Animals; Benzoates; beta-Alanine; Calcium-Binding Proteins; Disease Models, Animal; Humans; Intraocu

2021
Case Report: Topical Netarsudil in the Treatment of a Neurotrophic Corneal Ulcer.
    Optometry and vision science : official publication of the American Academy of Optometry, 2022, 07-01, Volume: 99, Issue:7

    Topics: Benzoates; beta-Alanine; Corneal Ulcer; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular H

2022
Pragmatic adjunctive usage of netarsudil: A retrospective chart review from a tertiary care center.
    Indian journal of ophthalmology, 2022, Volume: 70, Issue:8

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Benzoates; beta-Alanine; Female; Glaucoma; Glaucom

2022
Symptomatic Netarsudil-Induced Verticillata.
    JAMA ophthalmology, 2023, Nov-01, Volume: 141, Issue:11

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Glaucoma, Open-Angle; Humans; Intraocular Pressure

2023
Treatment of glaucoma and ocular hypertension using rho kinase inhibitors: patent evaluation of US2018244666 and US2018256595.
    Expert opinion on therapeutic patents, 2019, Volume: 29, Issue:10

    Topics: Benzoates; beta-Alanine; Glaucoma; Humans; Intraocular Pressure; Isoquinolines; Ocular Hypertension;

2019
Netarsudil/latanoprost fixed-dose combination for the treatment of open-angle glaucoma or ocular hypertension.
    Drugs of today (Barcelona, Spain : 1998), 2019, Volume: 55, Issue:9

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Drug Approval; Drug Therapy, Combination; Glaucoma

2019
Reticular Corneal Edema or Corneal Honeycombing in Eyes Treated With Netarsudil: A Case Series.
    Journal of glaucoma, 2020, Volume: 29, Issue:7

    Topics: Aged; Antihypertensive Agents; Benzoates; beta-Alanine; Corneal Edema; Female; Glaucoma, Open-Angle;

2020
Experience with netarsudil 0.02% and latanoprostene bunod 0.024% as adjunctive therapy for glaucoma.
    European journal of ophthalmology, 2022, Volume: 32, Issue:1

    Topics: Antihypertensive Agents; Benzoates; beta-Alanine; Cohort Studies; Glaucoma; Glaucoma, Open-Angle; Hu

2022
Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.
    eLife, 2021, 03-30, Volume: 10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antihypertensive Agents; Benzoates; beta-Alanin

2021
Netarsudil-related Eyelid Wound Dehiscence.
    Journal of glaucoma, 2021, Volume: 30, Issue:2

    Topics: Aged, 80 and over; Antihypertensive Agents; Benzoates; beta-Alanine; Eyelids; Glaucoma, Open-Angle;

2021
Safety and efficacy of topically administered netarsudil-latanoprost fixed dose combination (FDC; Rocklatan™) in normal and glaucomatous dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG).
    Veterinary ophthalmology, 2021, Volume: 24, Issue:6

    Topics: Animals; Antihypertensive Agents; Benzoates; beta-Alanine; Dog Diseases; Dogs; Double-Blind Method;

2021