Page last updated: 2024-10-16

beta-alanine and Gastrointestinal Hemorrhage

beta-alanine has been researched along with Gastrointestinal Hemorrhage in 33 studies

Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

Research Excerpts

ExcerptRelevanceReference
"The comparative safety of dabigatran versus warfarin for treatment of nonvalvular atrial fibrillation in general practice settings has not been established."7.81Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation. ( Goulding, MR; Graham, DJ; Houstoun, M; Kelman, JA; Levenson, M; MaCurdy, TE; Mott, K; Reichman, ME; Sheu, TC; Southworth, MR; Wernecke, M; Worrall, C; Zhang, R, 2015)
"Clinical trial data suggest that dabigatran and warfarin have similar rates of major bleeding but higher rates of gastrointestinal bleeding."7.80Bleeding rates in Veterans Affairs patients with atrial fibrillation who switch from warfarin to dabigatran. ( Chrischilles, E; Cram, P; Jones, M; Mazur, A; Vaughan Sarrazin, MS, 2014)
"In an 89-year-old female with atrial fibrillation dabigatran had been started 11 days before admission, following a transitory ischemic attack."7.79Ischemic stroke and intestinal bleeding under dabigatran in metabolic myopathy. ( Bastovansky, A; Finsterer, J; Paul, G; Stöllberger, C, 2013)
"This case demonstrates the potential of a single dose of dabigatran 150 mg to result in a fatal gastrointestinal hemorrhage."7.78Fatal gastrointestinal hemorrhage after a single dose of dabigatran. ( Boesen, K; Ito, S; Kernan, L; Shirazi, F, 2012)
"The comparative safety of dabigatran versus warfarin for treatment of nonvalvular atrial fibrillation in general practice settings has not been established."3.81Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation. ( Goulding, MR; Graham, DJ; Houstoun, M; Kelman, JA; Levenson, M; MaCurdy, TE; Mott, K; Reichman, ME; Sheu, TC; Southworth, MR; Wernecke, M; Worrall, C; Zhang, R, 2015)
"Incidence rates (events/100 patient years) and propensity score matched Cox proportional hazards models were used to estimate rates of total gastrointestinal bleeds, upper gastrointestinal bleeds, and lower gastrointestinal bleeds for the novel oral anticoagulants compared with warfarin in patients with and without atrial fibrillation."3.81Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population based cohort study. ( Abraham, NS; Alexander, GC; Crown, W; Haas, LR; Heien, H; Shah, ND; Singh, S, 2015)
"Clinical trial data suggest that dabigatran and warfarin have similar rates of major bleeding but higher rates of gastrointestinal bleeding."3.80Bleeding rates in Veterans Affairs patients with atrial fibrillation who switch from warfarin to dabigatran. ( Chrischilles, E; Cram, P; Jones, M; Mazur, A; Vaughan Sarrazin, MS, 2014)
"Dabigatran is an oral direct thrombin inhibitor that is Food and Drug Administration-approved for prevention of stroke in patients with atrial fibrillation."3.79Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. ( Hallows, KR; Henry, BL; Maw, TT; Nolin, TD; Pastor-Soler, NM; Singh, T; Unruh, ML, 2013)
"In an 89-year-old female with atrial fibrillation dabigatran had been started 11 days before admission, following a transitory ischemic attack."3.79Ischemic stroke and intestinal bleeding under dabigatran in metabolic myopathy. ( Bastovansky, A; Finsterer, J; Paul, G; Stöllberger, C, 2013)
"A 66-year-old woman treated with dabigatran for atrial fibrillation developed acute renal failure and upper gastrointestinal bleeding."3.78Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. ( Kouides, PA; Wychowski, MK, 2012)
"This case demonstrates the potential of a single dose of dabigatran 150 mg to result in a fatal gastrointestinal hemorrhage."3.78Fatal gastrointestinal hemorrhage after a single dose of dabigatran. ( Boesen, K; Ito, S; Kernan, L; Shirazi, F, 2012)
"Treatment with a PCC and FFP was administered to an 85-year-old man diagnosed with hemorrhagic shock secondary to bleeding in his upper gastrointestinal tract in an effort to reverse the anticoagulant effects of dabigatran."3.78Reversal of dabigatran-induced bleeding with a prothrombin complex concentrate and fresh frozen plasma. ( Dumkow, LE; Jennings, DL; Peters, M; Voss, JR, 2012)
" She was on dabigatran for atrial fibrillation and aspirin, with intermittent intake of ibuprofen."3.78Direct thrombin inhibitors: a case indicating benefit from 'plasmapheresis' in toxicity: a call for establishing "guidelines" in overdose and to find an "antidote"! ( Cirra, VR; Kamboj, J; Kamboj, R; Kottalgi, M; Shah, N, 2012)
"Seven were admitted for an intracranial hemorrhage (ICH) and four for a gastrointestinal hemorrhage (GIH)."1.40Clinical experience of life-threatening dabigatran-related bleeding at a large, tertiary care, academic medical center: a case series. ( Ditch, K; Miller, MA; Ross, B; Tran, M, 2014)
"227 dabigatran) were identified."1.40Risk of gastrointestinal bleeding with dabigatran: a head-to-head comparative study with rivaroxaban. ( Husein, H; Samo, S; Sherid, M; Sifuentes, H; Spurr, C; Sridhar, S; Sulaiman, S; Thiruvaiyaru, D; Tupper, R, 2014)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's33 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Holm, J1
Taskiran, M1
Southworth, MR2
Reichman, ME2
Unger, EF1
Desai, J1
Kolb, JM1
Weitz, JI1
Aisenberg, J1
Singh, T1
Maw, TT1
Henry, BL1
Pastor-Soler, NM1
Unruh, ML1
Hallows, KR1
Nolin, TD1
Diallo, I1
Mallaret, C1
Jourdan, S1
Brardjanian, S1
Guisset, M1
Coton, T1
Baron, TH1
Kamath, PS1
McBane, RD1
Thachil, J1
Pike, G1
Keighley-Jones, L1
Nash, MJ1
Bell, S1
Nand, J1
Dawes, M1
Braun, G1
Messmann, H1
Gunes, F1
Asik, M1
Temiz, A1
Binnetoglu, E1
Sen, H1
Bilen, Oİ1
Akbal, E1
Adam, G1
Ukinc, K1
Ribés-Cruz, JJ1
Torregrosa-Maicas, I1
Ramos-Tomás, C1
Solís-Salguero, MA1
Puchades-Montesa, MJ1
González-Rico, MA1
Juan-García, I1
Tomás-Simó, P1
Tejedor-Alonso, S1
Zambrano-Esteves, P1
Miguel-Carrasco, A1
Sipahi, I1
Celik, S1
Tozun, N1
Katz, MH1
Finsterer, J1
Stöllberger, C1
Paul, G1
Bastovansky, A1
Ross, B1
Miller, MA1
Ditch, K1
Tran, M1
Konturek, P1
Hess, T1
Vaughan Sarrazin, MS2
Jones, M1
Mazur, A1
Chrischilles, E1
Cram, P1
Clemens, A1
Strack, A1
Noack, H1
Konstantinides, S1
Brueckmann, M1
Lip, GY1
Sherid, M1
Sifuentes, H1
Sulaiman, S1
Samo, S1
Husein, H1
Tupper, R1
Thiruvaiyaru, D1
Spurr, C1
Sridhar, S1
Graham, DJ1
Wernecke, M1
Zhang, R1
Levenson, M1
Sheu, TC1
Mott, K1
Goulding, MR1
Houstoun, M1
MaCurdy, TE1
Worrall, C1
Kelman, JA1
Sengupta, N1
Feuerstein, JD1
Patwardhan, VR1
Tapper, EB1
Ketwaroo, GA1
Thaker, AM1
Leffler, DA1
Abraham, NS1
Singh, S2
Alexander, GC2
Heien, H1
Haas, LR1
Crown, W1
Shah, ND1
Rose, A1
Chang, HY1
Zhou, M1
Tang, W1
Chan, EW1
Lau, WC1
Leung, WK1
Mok, MT1
He, Y1
Tong, TS1
Wong, IC1
Phillips, R1
Lythgoe, M1
Lewis, LS1
Koretz, RL1
Wychowski, MK1
Kouides, PA1
Kernan, L1
Ito, S1
Shirazi, F1
Boesen, K1
Dumkow, LE1
Voss, JR1
Peters, M1
Jennings, DL1
Kamboj, J1
Kottalgi, M1
Cirra, VR1
Shah, N1
Kamboj, R1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Safety of Apixaban in Patients With Active Malignancy and Acute Deep Venous Thrombosis.[NCT04462003]Phase 3100 participants (Anticipated)Interventional2019-07-03Recruiting
Blood Flow Monitoring to Prevent Post-Polypectomy Induced Ulcer Bleeding.[NCT02875353]235 participants (Anticipated)Interventional2017-02-15Recruiting
A Monitor System for the Safety of Dabigatran Anticoagulation Treatment in Nonvalvular Atrial Fibrillation[NCT02414035]1,496 participants (Actual)Observational2015-03-22Completed
Randomized Evaluation of Decision Support Interventions for Atrial Fibrillation[NCT04357288]1,200 participants (Anticipated)Interventional2020-12-16Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for beta-alanine and Gastrointestinal Hemorrhage

ArticleYear
Gastrointestinal bleeding with the new oral anticoagulants--defining the issues and the management strategies.
    Thrombosis and haemostasis, 2013, Volume: 110, Issue:2

    Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran;

2013
New anticoagulant and antiplatelet agents: a primer for the gastroenterologist.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014, Volume: 12, Issue:2

    Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Blood Coagulation Factors; Cholangiopancreatography, E

2014
[Gastrointestinal bleeding in cardiological patients].
    Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2013, Volume: 108, Issue:8

    Topics: Algorithms; Anticoagulants; Benzimidazoles; beta-Alanine; Blood Coagulation Factors; Dabigatran; Dru

2013
A comparison of results of the US food and drug administration's mini-sentinel program with randomized clinical trials: the case of gastrointestinal tract bleeding with dabigatran.
    JAMA internal medicine, 2014, Volume: 174, Issue:1

    Topics: Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Databases, Pharmaceutical;

2014
[Gastrointestinal bleeding under treatment with new oral anticoagulants].
    MMW Fortschritte der Medizin, 2014, Feb-06, Volume: 156, Issue:2

    Topics: Administration, Oral; Aged; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacemen

2014

Other Studies

28 other studies available for beta-alanine and Gastrointestinal Hemorrhage

ArticleYear
[Dabigatran as cause of severe gastrointestinal bleeding in a Jehovah's Witness patient].
    Ugeskrift for laeger, 2013, Feb-04, Volume: 175, Issue:6

    Topics: Aged; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Blood Transfusion; Critical

2013
Dabigatran and postmarketing reports of bleeding.
    The New England journal of medicine, 2013, Apr-04, Volume: 368, Issue:14

    Topics: Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Gastrointestinal Hemorrhage

2013
Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience.
    Clinical journal of the American Society of Nephrology : CJASN, 2013, Volume: 8, Issue:9

    Topics: Accidental Falls; Acute Disease; Aged; Aged, 80 and over; Antithrombins; Atrial Fibrillation; Benzim

2013
[New oral anticoagulants and digestive hemorrhages].
    Presse medicale (Paris, France : 1983), 2014, Volume: 43, Issue:1

    Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Fe

2014
Plasma dabigatran activity one week after discontinuation despite normal renal function.
    The American journal of medicine, 2013, Volume: 126, Issue:8

    Topics: Aged; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Female; Gastroin

2013
Anticoagulation-associated upper gastrointestinal haemorrhage.
    Internal medicine journal, 2013, Volume: 43, Issue:8

    Topics: Aged; Aged, 80 and over; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Female; Gastroint

2013
Gastrointestinal bleeding associated with dabigatran in a patient with panhypopituitarism.
    Wiener klinische Wochenschrift, 2014, Volume: 126, Issue:1-2

    Topics: Aged; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Diagnosis, Differential; Embolism; Fe

2014
Dabigatran-induced upper intestinal bleeding in a patient with chronic kidney disease.
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2013, Nov-13, Volume: 33, Issue:6

    Topics: Aged, 80 and over; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Diabetes Mellitus,

2013
Multiple data sources, the best way to gather safety information about medications.
    JAMA internal medicine, 2014, Volume: 174, Issue:1

    Topics: Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Gastrointestinal Hemorrhage; Humans; Produc

2014
Ischemic stroke and intestinal bleeding under dabigatran in metabolic myopathy.
    Cardiovascular therapeutics, 2013, Volume: 31, Issue:6

    Topics: Aged; Aged, 80 and over; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Brain Isc

2013
Clinical experience of life-threatening dabigatran-related bleeding at a large, tertiary care, academic medical center: a case series.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2014, Volume: 10, Issue:2

    Topics: Academic Medical Centers; Aged; Aged, 80 and over; Antithrombins; Benzimidazoles; beta-Alanine; Comb

2014
Bleeding rates in Veterans Affairs patients with atrial fibrillation who switch from warfarin to dabigatran.
    The American journal of medicine, 2014, Volume: 127, Issue:12

    Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Al

2014
Anticoagulant-related gastrointestinal bleeding--could this facilitate early detection of benign or malignant gastrointestinal lesions?
    Annals of medicine, 2014, Volume: 46, Issue:8

    Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Top

2014
Risk of gastrointestinal bleeding with dabigatran: a head-to-head comparative study with rivaroxaban.
    Digestion, 2014, Volume: 90, Issue:2

    Topics: Aged; Aged, 80 and over; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Factor Xa Inhibito

2014
Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
    Circulation, 2015, Jan-13, Volume: 131, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Benzimidazoles

2015
Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
    Circulation, 2015, Jan-13, Volume: 131, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Benzimidazoles

2015
Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
    Circulation, 2015, Jan-13, Volume: 131, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Benzimidazoles

2015
Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
    Circulation, 2015, Jan-13, Volume: 131, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Benzimidazoles

2015
The risks of thromboembolism vs. recurrent gastrointestinal bleeding after interruption of systemic anticoagulation in hospitalized inpatients with gastrointestinal bleeding: a prospective study.
    The American journal of gastroenterology, 2015, Volume: 110, Issue:2

    Topics: Aged; Aged, 80 and over; Anticoagulants; Benzimidazoles; beta-Alanine; Cohort Studies; Dabigatran; E

2015
Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population based cohort study.
    BMJ (Clinical research ed.), 2015, Apr-24, Volume: 350

    Topics: Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Cohort S

2015
Safety of new oral anticoagulants.
    BMJ (Clinical research ed.), 2015, Apr-24, Volume: 350

    Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Female; Gastrointestinal Hemorrha

2015
Risk of gastrointestinal bleeding associated with oral anticoagulants: population based retrospective cohort study.
    BMJ (Clinical research ed.), 2015, Apr-24, Volume: 350

    Topics: Administration, Oral; Adult; Age Factors; Aged; Anticoagulants; Atrial Fibrillation; Benzimidazoles;

2015
Prevention of Dabigatran-Related Gastrointestinal Bleeding With Gastroprotective Agents: A Population-Based Study.
    Gastroenterology, 2015, Volume: 149, Issue:3

    Topics: Aged; Aged, 80 and over; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Female; Gastrointe

2015
Anticoagulation therapy: Bleeding no worse with novel agents.
    Nature reviews. Cardiology, 2015, Volume: 12, Issue:7

    Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Female; Gastrointestinal Hemorrha

2015
Effective antidotes for new anticoagulants.
    BMJ (Clinical research ed.), 2015, May-26, Volume: 350

    Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Female; Gastrointestinal Hemorrha

2015
Meta-analysis should not be subject to selectivity and imbalance.
    BMJ (Clinical research ed.), 2015, Jun-24, Volume: 350

    Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Female; Gastrointestinal Hemorrha

2015
Neither dabigatran nor rivaroxaban were linked to increased GI bleeding compared with warfarin.
    Annals of internal medicine, 2015, Sep-15, Volume: 163, Issue:6

    Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Female; Gastrointestinal Hemorrha

2015
Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment.
    The Annals of pharmacotherapy, 2012, Volume: 46, Issue:4

    Topics: Acute Kidney Injury; Aged; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Creati

2012
Fatal gastrointestinal hemorrhage after a single dose of dabigatran.
    Clinical toxicology (Philadelphia, Pa.), 2012, Volume: 50, Issue:7

    Topics: Aged; Aged, 80 and over; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Fatal Outcome; Ga

2012
Reversal of dabigatran-induced bleeding with a prothrombin complex concentrate and fresh frozen plasma.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2012, Oct-01, Volume: 69, Issue:19

    Topics: Aged, 80 and over; Antithrombins; Benzimidazoles; beta-Alanine; Blood Coagulation Factors; Dabigatra

2012
Direct thrombin inhibitors: a case indicating benefit from 'plasmapheresis' in toxicity: a call for establishing "guidelines" in overdose and to find an "antidote"!
    American journal of therapeutics, 2012, Volume: 19, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Antithrombins; Aspirin; Atrial Fibrillation; Ben

2012