beta-alanine has been researched along with Disease Models, Animal in 47 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leukotriene B4 (LTB4) is a highly potent neutrophil chemoattractant and neutrophils induces inflammatory response and oxidative stress when they recruit to and infiltrate in the injuried/inflamed site, such as the brain parenchyma after aneurysmal subarachnoid hemorrhage (SAH)." | 7.88 | Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats. ( Chen, Q; Hang, CH; Li, W; Liu, JP; Lu, Y; Wu, LY; Xia, DY; Ye, ZN; Zhang, XS; Zhang, ZH; Zhou, ML; Zhuang, Z, 2018) |
| "This experimental study of a rat ICH model indicates that dabigatran-related ICH may not increase the risk of delayed hematoma expansion." | 7.81 | Does dabigatran increase the risk of delayed hematoma expansion in a rat model of collagenase-induced intracerebral hemorrhage? ( Hirose, Y; Inamasu, J; Tanoue, S; Toyama, H; Yamada, M, 2015) |
| "Excessive anticoagulation with warfarin can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients, especially in those with chronic kidney disease (CKD)." | 7.80 | Warfarin-related nephropathy is the tip of the iceberg: direct thrombin inhibitor dabigatran induces glomerular hemorrhage with acute kidney injury in rats. ( Brodsky, SV; Hebert, L; Nadasdy, G; Nadasdy, T; Qamri, Z; Rovin, B; Ryan, M; Satoskar, A; Ware, K; Wu, H, 2014) |
| " After single intragastric administrations of HY023016, Dabigatran etexilate or tetramethylpyrazine, the anti-thrombotic activities were evaluated through rabbit jugular vein thrombosis model, rat inferior vena cava thrombosis model, ex vivo rabbit platelet aggregation assay, in vivo rabbit coagulation assay, and direct thrombin binding assay." | 7.79 | Antithrombotic activity of HY023016, a novel Dabigatran prodrug evaluated in animal thrombosis models. ( Gong, GQ; He, GW; Jiang, ML; Li, YZ; Wang, XH; Xu, YG; Yang, WH; Yang, XZ; Zhou, Y, 2013) |
| "Dabigatran treatment did not prevent or ameliorate the no-reflow phenomenon, suggesting that fibrin does not play a major role in the development of microvascular obstruction." | 5.42 | Dabigatran treatment: effects on infarct size and the no-reflow phenomenon in a model of acute myocardial ischemia/reperfusion. ( Hale, SL; Kloner, RA, 2015) |
| "Ischemic stroke was induced by transient middle cerebral artery occlusion (tMCAO) for 1 h or 3 h." | 5.38 | No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke. ( Bohmann, F; Foerch, C; Lindhoff-Last, E; Mirceska, A; Pfeilschifter, J; Pfeilschifter, W; Steinmetz, H, 2012) |
| "Leukotriene B4 (LTB4) is a highly potent neutrophil chemoattractant and neutrophils induces inflammatory response and oxidative stress when they recruit to and infiltrate in the injuried/inflamed site, such as the brain parenchyma after aneurysmal subarachnoid hemorrhage (SAH)." | 3.88 | Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats. ( Chen, Q; Hang, CH; Li, W; Liu, JP; Lu, Y; Wu, LY; Xia, DY; Ye, ZN; Zhang, XS; Zhang, ZH; Zhou, ML; Zhuang, Z, 2018) |
| "This experimental study of a rat ICH model indicates that dabigatran-related ICH may not increase the risk of delayed hematoma expansion." | 3.81 | Does dabigatran increase the risk of delayed hematoma expansion in a rat model of collagenase-induced intracerebral hemorrhage? ( Hirose, Y; Inamasu, J; Tanoue, S; Toyama, H; Yamada, M, 2015) |
| "Lack of specific antidotes is a major concern in intracerebral hemorrhage (ICH) related to direct anticoagulants including dabigatran (OAC-ICH)." | 3.81 | Idarucizumab Improves Outcome in Murine Brain Hemorrhage Related to Dabigatran. ( Mracsko, E; Na, SY; van Ryn, J; Veltkamp, R, 2015) |
| "Excessive anticoagulation with warfarin can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients, especially in those with chronic kidney disease (CKD)." | 3.80 | Warfarin-related nephropathy is the tip of the iceberg: direct thrombin inhibitor dabigatran induces glomerular hemorrhage with acute kidney injury in rats. ( Brodsky, SV; Hebert, L; Nadasdy, G; Nadasdy, T; Qamri, Z; Rovin, B; Ryan, M; Satoskar, A; Ware, K; Wu, H, 2014) |
| " After single intragastric administrations of HY023016, Dabigatran etexilate or tetramethylpyrazine, the anti-thrombotic activities were evaluated through rabbit jugular vein thrombosis model, rat inferior vena cava thrombosis model, ex vivo rabbit platelet aggregation assay, in vivo rabbit coagulation assay, and direct thrombin binding assay." | 3.79 | Antithrombotic activity of HY023016, a novel Dabigatran prodrug evaluated in animal thrombosis models. ( Gong, GQ; He, GW; Jiang, ML; Li, YZ; Wang, XH; Xu, YG; Yang, WH; Yang, XZ; Zhou, Y, 2013) |
| "Dabigatran etexilate (DE) has recently been introduced for stroke prevention in atrial fibrillation, but management of acute ischaemic stroke during therapy with DE is a challenge." | 3.79 | Anticoagulation with dabigatran does not increase secondary intracerebral haemorrhage after thrombolysis in experimental cerebral ischaemia. ( Ploen, R; Sun, L; Veltkamp, R; Zhou, W; Zorn, M, 2013) |
| "Both early treatment and late treatment with dabigatran etexilate attenuated the development of bleomycin-induced pulmonary fibrosis." | 3.77 | Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. ( Akter, T; Bogatkevich, GS; Ludwicka-Bradley, A; Nietert, PJ; Silver, RM; van Ryn, J, 2011) |
| "Neurolathyrism, konzo, and amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS-PDC) have attracted researchers to study the pathology of motor neuron (MN) diseases such as ALS." | 2.61 | [Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism]. ( Kusama-Eguchi, K, 2019) |
| "Acute mesenteric ischemia arises through sudden interruption of mesenteric blood flow, mostly due to an occlusion of the superior mesenteric artery and is associated with a high mortality of approximately 50% to 90%." | 1.62 | Synergistic Effect of β-alanine and Aprotinin on Mesenteric Ischemia. ( Dominowski, L; Kirsch, M, 2021) |
| "Future treatments of multiple sclerosis (MS), a chronic autoimmune neurodegenerative disease of the central nervous system (CNS), aim for simultaneous early targeting of peripheral immune function and neuroinflammation." | 1.56 | Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis. ( Balletta, S; Bruno, A; Bullitta, S; Buttari, F; Caioli, S; Centonze, D; De Vito, F; Dolcetti, E; Fresegna, D; Gentile, A; Guadalupi, L; Mandolesi, G; Musella, A; Nencini, M; Rizzo, FR; Sanna, K; Stampanoni Bassi, M; Vanni, V; Vitiello, L, 2020) |
| " Ester 60 improved bioavailability of its parent ROCK inhibitor, 29 (Ki=0." | 1.43 | Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma. ( deLong, MA; Heintzelman, GR; Kopczynski, CC; Laethem, CL; Lin, CW; Moore, LA; Royalty, SM; Sherman, B; Sturdivant, JM; Yingling, JD, 2016) |
| "Dabigatran treatment did not prevent or ameliorate the no-reflow phenomenon, suggesting that fibrin does not play a major role in the development of microvascular obstruction." | 1.42 | Dabigatran treatment: effects on infarct size and the no-reflow phenomenon in a model of acute myocardial ischemia/reperfusion. ( Hale, SL; Kloner, RA, 2015) |
| "Xanthomas were mainly located in fibrillin-1-rich regions, such as the choroid plexus and the neocortex." | 1.42 | Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice. ( Bauters, D; Bink, DI; Blockx, I; Daemen, MJ; De Meyer, GR; Martinet, W; Pintelon, I; Ritz, K; Roth, L; Timmermans, JP; Van der Donckt, C; Vanhoutte, G; Verhoye, M, 2015) |
| "Ischemic stroke was induced by transient middle cerebral artery occlusion (tMCAO) for 1 h or 3 h." | 1.38 | No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke. ( Bohmann, F; Foerch, C; Lindhoff-Last, E; Mirceska, A; Pfeilschifter, J; Pfeilschifter, W; Steinmetz, H, 2012) |
| "Neurolathyrism (NL) is a motor neuron disease characterized by spastic paraparesis in the hind legs." | 1.38 | Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis. ( Kawaguchi, K; Kusama-Eguchi, K; Lambein, F, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.13) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (21.28) | 29.6817 |
| 2010's | 29 (61.70) | 24.3611 |
| 2020's | 7 (14.89) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 3 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Chen, YH | 1 |
| Lin, WY | 1 |
| Huang, YC | 1 |
| Ho, WY | 1 |
| Fu, CW | 1 |
| Tu, CM | 1 |
| Hwang, CS | 1 |
| Hung, CL | 1 |
| Lin, MC | 1 |
| Cheng, F | 1 |
| Wang, YJ | 1 |
| Chen, CH | 1 |
| Chou, SH | 1 |
| She, MP | 1 |
| Yang, CY | 1 |
| Cheng, HL | 1 |
| Liu, CP | 1 |
| Lu, DW | 1 |
| Jing, Y | 1 |
| Bai, F | 1 |
| Wang, L | 1 |
| Yang, D | 2 |
| Yan, Y | 1 |
| Wang, Q | 1 |
| Zhu, Y | 1 |
| Yu, Y | 1 |
| Chen, Z | 1 |
| Musella, A | 1 |
| Gentile, A | 1 |
| Guadalupi, L | 1 |
| Rizzo, FR | 1 |
| De Vito, F | 1 |
| Fresegna, D | 1 |
| Bruno, A | 1 |
| Dolcetti, E | 1 |
| Vanni, V | 1 |
| Vitiello, L | 1 |
| Bullitta, S | 1 |
| Sanna, K | 1 |
| Caioli, S | 1 |
| Balletta, S | 1 |
| Nencini, M | 1 |
| Buttari, F | 1 |
| Stampanoni Bassi, M | 1 |
| Centonze, D | 1 |
| Mandolesi, G | 1 |
| Dominowski, L | 1 |
| Kirsch, M | 1 |
| Zhang, S | 1 |
| Edwards, TN | 1 |
| Chaudhri, VK | 1 |
| Wu, J | 1 |
| Cohen, JA | 1 |
| Hirai, T | 1 |
| Rittenhouse, N | 1 |
| Schmitz, EG | 1 |
| Zhou, PY | 1 |
| McNeil, BD | 1 |
| Yang, Y | 2 |
| Koerber, HR | 1 |
| Sumpter, TL | 1 |
| Poholek, AC | 1 |
| Davis, BM | 1 |
| Albers, KM | 1 |
| Singh, H | 1 |
| Kaplan, DH | 1 |
| Stefani, GP | 1 |
| Capalonga, L | 1 |
| da Silva, LR | 1 |
| Heck, TG | 1 |
| Frizzo, MN | 1 |
| Sulzbacher, LM | 1 |
| Sulzbacher, MM | 1 |
| de Batista, D | 1 |
| Vedovatto, S | 1 |
| Bertoni, APS | 1 |
| Wink, MR | 1 |
| Dal Lago, P | 1 |
| Ye, ZN | 1 |
| Wu, LY | 1 |
| Liu, JP | 1 |
| Chen, Q | 1 |
| Zhang, XS | 1 |
| Lu, Y | 1 |
| Zhou, ML | 1 |
| Zhang, ZH | 1 |
| Xia, DY | 1 |
| Zhuang, Z | 1 |
| Hang, CH | 1 |
| García-Ayuso, D | 1 |
| Di Pierdomenico, J | 1 |
| Hadj-Said, W | 1 |
| Marie, M | 1 |
| Agudo-Barriuso, M | 1 |
| Vidal-Sanz, M | 1 |
| Picaud, S | 1 |
| Villegas-Pérez, MP | 1 |
| Kusama-Eguchi, K | 3 |
| Vanassche, T | 1 |
| Peetermans, M | 1 |
| Van Aelst, LN | 1 |
| Peetermans, WE | 1 |
| Verhaegen, J | 1 |
| Missiakas, DM | 1 |
| Schneewind, O | 1 |
| Hoylaerts, MF | 1 |
| Verhamme, P | 1 |
| Li, YZ | 1 |
| Gong, GQ | 1 |
| Yang, WH | 1 |
| Wang, XH | 1 |
| Jiang, ML | 1 |
| Zhou, Y | 1 |
| Yang, XZ | 1 |
| Xu, YG | 1 |
| He, GW | 1 |
| Sun, L | 1 |
| Zhou, W | 1 |
| Ploen, R | 1 |
| Zorn, M | 1 |
| Veltkamp, R | 2 |
| Ryan, M | 1 |
| Ware, K | 1 |
| Qamri, Z | 1 |
| Satoskar, A | 1 |
| Wu, H | 1 |
| Nadasdy, G | 2 |
| Rovin, B | 1 |
| Hebert, L | 1 |
| Nadasdy, T | 2 |
| Brodsky, SV | 2 |
| Kono, S | 1 |
| Deguchi, K | 1 |
| Omote, Y | 1 |
| Yunoki, T | 1 |
| Yamashita, T | 1 |
| Kurata, T | 1 |
| Ikeda, Y | 1 |
| Abe, K | 1 |
| Sparkenbaugh, EM | 1 |
| Chantrathammachart, P | 1 |
| Mickelson, J | 1 |
| van Ryn, J | 4 |
| Hebbel, RP | 1 |
| Monroe, DM | 1 |
| Mackman, N | 1 |
| Key, NS | 1 |
| Pawlinski, R | 1 |
| Grottke, O | 1 |
| Spronk, HM | 1 |
| Rossaint, R | 1 |
| Chen, G | 1 |
| Li, J | 1 |
| Cheng, K | 1 |
| Tang, G | 1 |
| Zhang, R | 1 |
| Zhou, J | 1 |
| Liu, Z | 1 |
| Fan, S | 1 |
| Xie, P | 1 |
| Hale, SL | 1 |
| Kloner, RA | 1 |
| Ware, KM | 1 |
| Vance, JC | 1 |
| Muni, N | 1 |
| Hebert, LA | 1 |
| Satoskar, AA | 1 |
| Ivanov, I | 1 |
| Rovin, BH | 1 |
| Liu, P | 1 |
| Wu, C | 1 |
| Song, W | 1 |
| Yu, L | 1 |
| Yang, X | 2 |
| Xiang, R | 1 |
| Wang, F | 1 |
| Yang, J | 1 |
| Tanoue, S | 1 |
| Inamasu, J | 1 |
| Yamada, M | 1 |
| Toyama, H | 1 |
| Hirose, Y | 1 |
| Valtcheva, MV | 1 |
| Davidson, S | 1 |
| Zhao, C | 1 |
| Leitges, M | 1 |
| Gereau, RW | 1 |
| Hoffman, JR | 1 |
| Ostfeld, I | 1 |
| Stout, JR | 1 |
| Harris, RC | 1 |
| Kaplan, Z | 1 |
| Cohen, H | 1 |
| Van der Donckt, C | 1 |
| Roth, L | 1 |
| Vanhoutte, G | 1 |
| Blockx, I | 1 |
| Bink, DI | 1 |
| Ritz, K | 1 |
| Pintelon, I | 1 |
| Timmermans, JP | 1 |
| Bauters, D | 1 |
| Martinet, W | 1 |
| Daemen, MJ | 1 |
| Verhoye, M | 1 |
| De Meyer, GR | 1 |
| Na, SY | 1 |
| Mracsko, E | 1 |
| Stegen, S | 1 |
| Stegen, B | 1 |
| Aldini, G | 1 |
| Altomare, A | 1 |
| Cannizzaro, L | 1 |
| Orioli, M | 1 |
| Gerlo, S | 1 |
| Deldicque, L | 1 |
| Ramaekers, M | 1 |
| Hespel, P | 1 |
| Derave, W | 1 |
| Russ, DW | 1 |
| Acksel, C | 1 |
| Boyd, IM | 1 |
| Maynard, J | 1 |
| McCorkle, KW | 1 |
| Edens, NK | 1 |
| Garvey, SM | 1 |
| Sturdivant, JM | 1 |
| Royalty, SM | 1 |
| Lin, CW | 1 |
| Moore, LA | 1 |
| Yingling, JD | 1 |
| Laethem, CL | 1 |
| Sherman, B | 1 |
| Heintzelman, GR | 1 |
| Kopczynski, CC | 1 |
| deLong, MA | 1 |
| Shaw, PX | 1 |
| Sang, A | 1 |
| Wang, Y | 1 |
| Ho, D | 1 |
| Douglas, C | 1 |
| Dia, L | 1 |
| Goldberg, JL | 1 |
| Zhang, ZY | 1 |
| Zhang, Z | 1 |
| Zug, C | 1 |
| Nuesslein-Hildesheim, B | 1 |
| Leppert, D | 1 |
| Schluesener, HJ | 1 |
| Zahn, G | 1 |
| Vossmeyer, D | 1 |
| Stragies, R | 1 |
| Wills, M | 1 |
| Wong, CG | 1 |
| Löffler, KU | 1 |
| Adamis, AP | 1 |
| Knolle, J | 1 |
| Mendez, MP | 1 |
| Monroy, YK | 1 |
| Du, M | 1 |
| Preston, AM | 1 |
| Tolle, L | 1 |
| Lin, Y | 1 |
| VanDussen, KL | 1 |
| Samuelson, LC | 1 |
| Standiford, TJ | 1 |
| Curtis, JL | 1 |
| Beck, JM | 1 |
| Christensen, PJ | 1 |
| Paine, R | 1 |
| Bogatkevich, GS | 1 |
| Ludwicka-Bradley, A | 1 |
| Nietert, PJ | 1 |
| Akter, T | 1 |
| Silver, RM | 1 |
| Pfeilschifter, W | 2 |
| Bohmann, F | 2 |
| Baumgarten, P | 1 |
| Mittelbronn, M | 1 |
| Pfeilschifter, J | 2 |
| Lindhoff-Last, E | 2 |
| Steinmetz, H | 2 |
| Foerch, C | 2 |
| Xiong, Y | 1 |
| Guo, J | 1 |
| Candelore, MR | 1 |
| Liang, R | 1 |
| Miller, C | 1 |
| Dallas-Yang, Q | 1 |
| Jiang, G | 1 |
| McCann, PE | 1 |
| Qureshi, SA | 1 |
| Tong, X | 1 |
| Xu, SS | 1 |
| Shang, J | 1 |
| Vincent, SH | 1 |
| Tota, LM | 1 |
| Wright, MJ | 1 |
| Zhang, BB | 1 |
| Tata, JR | 1 |
| Parmee, ER | 1 |
| Mirceska, A | 1 |
| Kawaguchi, K | 1 |
| Lambein, F | 1 |
| Ishiwari, K | 1 |
| Mingote, S | 1 |
| Correa, M | 1 |
| Trevitt, JT | 1 |
| Carlson, BB | 1 |
| Salamone, JD | 1 |
| Ikegami, F | 1 |
| Kusama, T | 1 |
| Suda, A | 1 |
| Ogawa, Y | 1 |
| Igarashi, K | 1 |
| Watanabe, K | 1 |
| Mozaffari, MS | 1 |
| Patel, C | 1 |
| Abdelsayed, R | 1 |
| Schaffer, SW | 1 |
| Tani, H | 1 |
| Bandrowski, AE | 1 |
| Parada, I | 1 |
| Wynn, M | 1 |
| Huguenard, JR | 1 |
| Prince, DA | 1 |
| Reimer, RJ | 1 |
| Amartey, JK | 1 |
| Shi, Y | 1 |
| Al-Jammaz, I | 1 |
| Esguerra, C | 1 |
| Al-Otaibi, B | 1 |
| Al-Mohanna, F | 1 |
| Ogawa, T | 1 |
| Sugidachi, A | 1 |
| Naganuma, H | 1 |
| Asai, F | 1 |
| Fukuoka, T | 1 |
| Inoue, H | 1 |
| Abe, T | 1 |
| Ohya, S | 1 |
| Gibson, KM | 1 |
| Schor, DS | 1 |
| Gupta, M | 1 |
| Guerand, WS | 1 |
| Senephansiri, H | 1 |
| Burlingame, TG | 1 |
| Bartels, H | 1 |
| Hogema, BM | 1 |
| Bottiglieri, T | 1 |
| Froestl, W | 1 |
| Snead, OC | 1 |
| Grompe, M | 1 |
| Jakobs, C | 1 |
| Spencer, PS | 1 |
| Roy, DN | 1 |
| Ludolph, A | 1 |
| Hugon, J | 1 |
| Dwivedi, MP | 1 |
| Schaumburg, HH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Ozanimod on Immune-mediated Mechanisms of Neurodegeneration in Multiple Sclerosis - a Preclinical Study[NCT05245344] | 154 participants (Anticipated) | Observational | 2022-04-01 | Not yet recruiting | |||
| Can Rivaroxaban Lead to Anticoagulation-Related Nephropathy?[NCT02900170] | 8 participants (Actual) | Observational | 2016-07-31 | Completed | |||
| Clinical and Imaging Biomarker Trial of Uridine for Veterans With Suicidal Ideation[NCT03265964] | Phase 4 | 90 participants (Anticipated) | Interventional | 2018-04-02 | Recruiting | ||
| Optimal Delay Time to Initiate Anticoagulation After Ischemic Stroke in Atrial Fibrillation[NCT03021928] | Phase 3 | 200 participants (Actual) | Interventional | 2017-06-14 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Primary endpoint - Incidence of ARN is the primary outcome of this study and this is based on a documentation of AKI (defined as an increase in baseline serum creatinine ≥ 0.3 mg/dL), in the absence of any other obvious etiology for the AKI identified after a standard clinical evaluation and work up by the patient's primary care physician, cardiologist or nephrologist. This incidence will be expressed as a percentage. (NCT02900170)
Timeframe: 6 months
| Intervention | Percentage of participants (Number) |
|---|---|
| Participants | 0 |
1 review available for beta-alanine and Disease Models, Animal
| Article | Year |
|---|---|
[Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta-Alanine; Cell Death; Disease | 2019 |
46 other studies available for beta-alanine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models.
Topics: Animals; Benzoates; beta-Alanine; Calcium-Binding Proteins; Disease Models, Animal; Humans; Intraocu | 2021 |
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site.
Topics: Animals; beta-Alanine; Disease Models, Animal; Fecal Microbiota Transplantation; Inflammation; Mice; | 2022 |
Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis.
Topics: Animals; Anti-Inflammatory Agents; beta-Alanine; Cell Line; Central Nervous System; Disease Models, | 2020 |
Synergistic Effect of β-alanine and Aprotinin on Mesenteric Ischemia.
Topics: Animals; Aprotinin; beta-Alanine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; | 2021 |
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.
Topics: Animals; beta-Alanine; Cells, Cultured; Dermatitis; Diphtheria Toxin; Disease Models, Animal; Female | 2021 |
Effects of aerobic and resistance exercise training associated with carnosine precursor supplementation on maximal strength and V̇O
Topics: Animals; beta-Alanine; Carnosine; Disease Models, Animal; Heart Failure; Histidine; Male; Oxygen; Ph | 2021 |
Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats.
Topics: Animals; beta-Alanine; Blood-Brain Barrier; Brain Edema; Brain Injuries; Disease Models, Animal; Inf | 2018 |
Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration.
Topics: Animals; beta-Alanine; Cell Survival; Disease Models, Animal; Light; Photoreceptor Cells, Vertebrate | 2018 |
The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.
Topics: Animals; Bacterial Adhesion; Bacterial Load; Benzimidazoles; beta-Alanine; Catheter-Related Infectio | 2013 |
Antithrombotic activity of HY023016, a novel Dabigatran prodrug evaluated in animal thrombosis models.
Topics: Animals; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Disease Models, Animal; Mice; Prod | 2013 |
Anticoagulation with dabigatran does not increase secondary intracerebral haemorrhage after thrombolysis in experimental cerebral ischaemia.
Topics: Animals; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Blood-Brain Barrier; Cerebral | 2013 |
Warfarin-related nephropathy is the tip of the iceberg: direct thrombin inhibitor dabigatran induces glomerular hemorrhage with acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatra | 2014 |
Reducing hemorrhagic complication by dabigatran via neurovascular protection after recanalization with tissue plasminogen activator in ischemic stroke of rat.
Topics: Animals; Antithrombins; Benzimidazoles; beta-Alanine; Brain Ischemia; Dabigatran; Disease Models, An | 2014 |
Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Bone Marr | 2014 |
Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model.
Topics: Animals; Antidotes; Benzimidazoles; beta-Alanine; Blood Coagulation; Blood Coagulation Factors; Bloo | 2014 |
Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; beta-Alanine; Depressive Disorder, Major; Dis | 2015 |
Dabigatran treatment: effects on infarct size and the no-reflow phenomenon in a model of acute myocardial ischemia/reperfusion.
Topics: Animals; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Disease Models, Animal; Male; Myoc | 2015 |
Oral warfarin and the thrombin inhibitor dabigatran increase blood pressure in rats: hidden danger of anticoagulants?
Topics: Acetylcysteine; Animals; Anticoagulants; Antifibrinolytic Agents; Antithrombins; Benzimidazoles; bet | 2015 |
Uridine decreases morphine-induced behavioral sensitization by decreasing dorsal striatal dopamine release possibly via agonistic effects at GABAA receptors.
Topics: Analgesics, Opioid; Animals; Animals, Inbred Strains; beta-Alanine; Bicuculline; Corpus Striatum; Di | 2014 |
Does dabigatran increase the risk of delayed hematoma expansion in a rat model of collagenase-induced intracerebral hemorrhage?
Topics: Animals; Antithrombins; Benzimidazoles; beta-Alanine; Cerebral Hemorrhage; Collagenases; Dabigatran; | 2015 |
Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors.
Topics: Animals; beta-Alanine; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Chloroq | 2015 |
β-Alanine supplemented diets enhance behavioral resilience to stress exposure in an animal model of PTSD.
Topics: Animals; Behavior, Animal; beta-Alanine; Dietary Supplements; Disease Models, Animal; Male; Rats; Ra | 2015 |
Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice.
Topics: Acrylamides; Animals; Apolipoproteins E; beta-Alanine; Blood-Brain Barrier; Brain; Brain Diseases; C | 2015 |
Idarucizumab Improves Outcome in Murine Brain Hemorrhage Related to Dabigatran.
Topics: Animals; Antibodies, Monoclonal, Humanized; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alan | 2015 |
Plasma carnosine, but not muscle carnosine, attenuates high-fat diet-induced metabolic stress.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; beta-Alanine; Blood Glucose; Carnosine; Die | 2015 |
Dietary HMB and β-alanine co-supplementation does not improve in situ muscle function in sedentary, aged male rats.
Topics: Age Factors; Aging; Animals; Autophagy; beta-Alanine; Biomarkers; Dietary Supplements; Disease Model | 2015 |
Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma.
Topics: Animals; Benzoates; beta-Alanine; Disease Models, Animal; Drug Evaluation, Preclinical; Glaucoma, Op | 2016 |
Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury.
Topics: Administration, Topical; Animals; Axons; Benzoates; beta-Alanine; Blotting, Western; Cell Survival; | 2017 |
AUY954, a selective S1P(1) modulator, prevents experimental autoimmune neuritis.
Topics: Animals; B-Lymphocytes; beta-Alanine; Chemotaxis, Leukocyte; Disease Models, Animal; Guillain-Barre | 2009 |
Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.
Topics: Aminopyridines; Angiogenesis Inhibitors; Animals; beta-Alanine; Choroidal Neovascularization; Diseas | 2009 |
Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia.
Topics: Acrylamides; Animals; beta-Alanine; Cells, Cultured; Chemokine CXCL2; Chemotaxis; Disease Models, An | 2011 |
Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease.
Topics: Administration, Oral; Animals; Antithrombins; Benzimidazoles; beta-Alanine; Bleomycin; Dabigatran; D | 2011 |
Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke.
Topics: Animals; Anticoagulants; Benzimidazoles; beta-Alanine; Cerebral Hemorrhage; Dabigatran; Disease Mode | 2012 |
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.
Topics: Animals; Area Under Curve; beta-Alanine; Blood Glucose; CHO Cells; Cricetinae; Cricetulus; Diabetes | 2012 |
No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke.
Topics: Administration, Oral; Animals; Antithrombins; Benzimidazoles; beta-Alanine; Blood Coagulation; Cereb | 2012 |
Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis.
Topics: Animals; beta-Alanine; Blood Vessels; Disease Models, Animal; Heme Oxygenase-1; Hemorrhage; Human Um | 2012 |
The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis.
Topics: Animals; beta-Alanine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response R | 2004 |
A rat model of neurolathyrism: repeated injection of L: -beta-ODAP induces the paraparesis of the hind legs.
Topics: Animals; Animals, Newborn; beta-Alanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Inf | 2005 |
Accelerated NaCl-induced hypertension in taurine-deficient rat: role of renal function.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Baroreflex; beta-Alanine; Blood Pr | 2006 |
Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy.
Topics: Action Potentials; Amino Acid Transport System A; Amino Acid Transport Systems; Animals; beta-Alanin | 2007 |
Radioiodinated naphthylalanine derivatives targeting pancreatic beta cells in normal and nonobese diabetic mice.
Topics: Animals; Autoradiography; beta-Alanine; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dia | 2008 |
Antiplatelet and antithrombotic effects of orbofiban, a new orally active GPIIb/IIIa antagonist, in guinea pigs.
Topics: Adenosine Diphosphate; Administration, Oral; Alanine; Animals; Arteriovenous Shunt, Surgical; Aspiri | 2000 |
[In vitro and in vivo activities of panipenem against penicillin-resistant Streptococcus pneumoniae].
Topics: Ampicillin; Animals; beta-Alanine; Cefozopran; Ceftriaxone; Cephalosporins; Cilastatin; Cilastatin, | 2001 |
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.
Topics: Aldehyde Oxidoreductases; Animals; beta-Alanine; Blotting, Western; Brain; Carboxylic Acids; Disease | 2002 |
Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.
Topics: Adolescent; Adult; Alanine; Amino Acids, Diamino; Animals; beta-Alanine; Central Nervous System; Chi | 1986 |