beta-acetyldigoxin and Myocarditis

beta-acetyldigoxin has been researched along with Myocarditis* in 2 studies

Other Studies

2 other study(ies) available for beta-acetyldigoxin and Myocarditis

Article	Year
Submolecular mechanisms underlying in vitro and in vivo effect of cardiac glycosides on contractile activity of myocardial myofibrils during heart failure. Bulletin of experimental biology and medicine, 2006, Volume: 141, Issue:4 The development of severe heart failure associated with toxicoallergic myocarditis is accompanied by profound structural and conformational changes in the outer domain of actin (major protein in a thin filament of cardiomyocyte sarcomere). These changes were revealed in subdomains 1 (Cys374 and Cys10) and 2 (Lys61 and Tyr69). Structural and conformational changes in the monomer and protomer of the actin thread during heart failure were energetically forbidden. Variations in the distance between amino acid residues exceeded 0.26 nm. They were partly or completely reversible in vivo under the influence of cardiotropic drug refracterin with high antihypoxic activity, as well as in vitro after treatment with digitalis preparations optimizing the concentration of ATP. Topics: Acetyldigoxins; Animals; Cardiac Glycosides; Heart Diseases; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscles; Myocardial Contraction; Myocardial Ischemia; Myocarditis; Myofibrils; Rabbits	2006
[Effects of strophanthin K and beta-acetyldigoxin in vitro on energy transformation of myocardial contractile protein system in toxic-allergic lesions of the cardiac muscle]. Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:5 Strophanthin K and beta-acetyldigoxin in vitro in concentration of 10(-6) M in TAM sharply increased the force generated by isolated myocardial contractile protein system (MCPS), and normalized the work performed by the system. This was accompanied by increase of ATP internal energy release (enthalpy) intensity, while a portion of energy, dissipating into heat did not increase proportionally. The mechanical efficiency of contractile process was normalized due to beta-acetyldigoxin, and exceeded the normal level due to strophanthin K effect. Strophanthin K proved a positive effect on quantitative and qualitative economy of MCPS energy utilization, while beta-acetyldigoxin effected, on the whole, extensively. Topics: Acetyldigoxins; Animals; Contractile Proteins; Heart; Hypersensitivity; In Vitro Techniques; Myocardial Contraction; Myocarditis; Myocardium; Rabbits; Strophanthins	1991

Article

Year

Submolecular mechanisms underlying in vitro and in vivo effect of cardiac glycosides on contractile activity of myocardial myofibrils during heart failure.

Bulletin of experimental biology and medicine, 2006, Volume: 141, Issue:4

The development of severe heart failure associated with toxicoallergic myocarditis is accompanied by profound structural and conformational changes in the outer domain of actin (major protein in a thin filament of cardiomyocyte sarcomere). These changes were revealed in subdomains 1 (Cys374 and Cys10) and 2 (Lys61 and Tyr69). Structural and conformational changes in the monomer and protomer of the actin thread during heart failure were energetically forbidden. Variations in the distance between amino acid residues exceeded 0.26 nm. They were partly or completely reversible in vivo under the influence of cardiotropic drug refracterin with high antihypoxic activity, as well as in vitro after treatment with digitalis preparations optimizing the concentration of ATP.

Topics: Acetyldigoxins; Animals; Cardiac Glycosides; Heart Diseases; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscles; Myocardial Contraction; Myocardial Ischemia; Myocarditis; Myofibrils; Rabbits

2006

[Effects of strophanthin K and beta-acetyldigoxin in vitro on energy transformation of myocardial contractile protein system in toxic-allergic lesions of the cardiac muscle].

Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 111, Issue:5

Strophanthin K and beta-acetyldigoxin in vitro in concentration of 10(-6) M in TAM sharply increased the force generated by isolated myocardial contractile protein system (MCPS), and normalized the work performed by the system. This was accompanied by increase of ATP internal energy release (enthalpy) intensity, while a portion of energy, dissipating into heat did not increase proportionally. The mechanical efficiency of contractile process was normalized due to beta-acetyldigoxin, and exceeded the normal level due to strophanthin K effect. Strophanthin K proved a positive effect on quantitative and qualitative economy of MCPS energy utilization, while beta-acetyldigoxin effected, on the whole, extensively.

Topics: Acetyldigoxins; Animals; Contractile Proteins; Heart; Hypersensitivity; In Vitro Techniques; Myocardial Contraction; Myocarditis; Myocardium; Rabbits; Strophanthins

1991