beta-acetyldigoxin and Heart-Diseases

Topics: Acetyldigoxins; Adult; Aged; Calcium; Clinical Trials as Topic; Digoxin; Female; Heart Diseases; Humans; Male; Medigoxin; Middle Aged; Potassium

The development of severe heart failure associated with toxicoallergic myocarditis is accompanied by profound structural and conformational changes in the outer domain of actin (major protein in a thin filament of cardiomyocyte sarcomere). These changes were revealed in subdomains 1 (Cys374 and Cys10) and 2 (Lys61 and Tyr69). Structural and conformational changes in the monomer and protomer of the actin thread during heart failure were energetically forbidden. Variations in the distance between amino acid residues exceeded 0.26 nm. They were partly or completely reversible in vivo under the influence of cardiotropic drug refracterin with high antihypoxic activity, as well as in vitro after treatment with digitalis preparations optimizing the concentration of ATP.

Topics: Acetyldigoxins; Animals; Cardiac Glycosides; Heart Diseases; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscles; Myocardial Contraction; Myocardial Ischemia; Myocarditis; Myofibrils; Rabbits

As part of a blood-pressure survey in Munich, some of its inhabitants aged 30-69 years were asked by questionnaire about any digitalis medication. Chemically defined glycosides were taken by 127 of 1827 persons (7%), two-thirds of them older than 60 years, for clinically compensated chronic heart failure. Using the equation of Cockcroft and Gault to calculate creatinine clearance, it was below 80 ml/min and thus indicative of early impairment of renal function in more than 50%. In 44% the prescribed daily dose of glycoside corresponded to the calculated maintenance dose, 29% had less and 27% had taken more. None had clinical signs of digitalis intoxication. ECG changes possibly due to digitalis were much less common than had been expected. Sinus rhythm was present in 93%. More than 50% did not know why they were taking digitalis and 80% were taking two or more drugs at the same time. Since more than half had signs of early renal function impairment, creatinine clearance should be taken into account when determining the dosage of a digoxin preparation especially in elderly patients; alternatively, digitoxin should be prescribed. The survey also showed that a large number of persons on glycoside medication did not take the drug regularly.

Topics: Acetyldigoxins; Adult; Age Factors; Aged; Creatinine; Digitalis Glycosides; Digitoxin; Digoxin; Electrocardiography; Female; Germany, West; Heart; Heart Diseases; Humans; Hypertension; Kidney; Male; Middle Aged; Prospective Studies; Sex Factors

Investigations were performed in order to study whether or not quinidine would exert similar effects on the serum digoxin concentration in patients with renal failure as in normal subjects. Fourteen out of fifteen patients showed a significant increase of the serum digoxin level after four days of quinidine application. This indicates, that the quinidine effect is not solely caused by a decrease of the renal digoxin clearance, although nine patients, not being hemodialysed, revealed a correlation between their creatinine clearance and the rise of the serum digoxin concentration after quinidine. As however, the patients on hemodialysis did not show higher digoxin levels than those treated conservatively, it is suggested that the degree of the uremic intoxication might be responsible for the observed correlation.

Topics: Acetyldigoxins; Adult; Aged; Creatinine; Digoxin; Drug Interactions; Electrocardiography; Female; Heart Diseases; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Quinidine; Renal Dialysis

Topics: Absorption; Acetyldigoxins; Aged; Digoxin; Female; Heart Diseases; Humans; Male; Medigoxin; Middle Aged

Topics: Acetyldigoxins; Administration, Oral; Adult; Aged; Biological Availability; Deslanoside; Digoxin; Female; Heart Diseases; Humans; Lanatosides; Male; Middle Aged

Topics: Acetyldigoxins; Biomedical Research; Digitalis Glycosides; Diuretics; Drug Therapy; Electrocardiography; Heart Diseases; Toxicology

Topics: Acetyldigitoxins; Acetyldigoxins; Cardiotonic Agents; Heart Diseases; Humans; Oligosaccharides; Rubiaceae