beta-acetyldigoxin and Coronary-Disease

Composite preparation refracterin administered in a dose of 300 mg/day for 3 days in addition to routine therapy significantly improved the results of treatment of severe cardiac insufficiency of ischemic genesis compared to placebo. Improvement of clinical status of patients is determined by positive dynamics of systolic and diastolic functions of the left ventricle.

Topics: Acetyldigoxins; Aged; Cardiac Output, Low; Cardiotonic Agents; Chronic Disease; Coronary Disease; Cytochromes c; Drug Combinations; Echocardiography; Female; Humans; Inosine; Male; Middle Aged; NAD; Oxyfedrine; Systole; Treatment Outcome; Ventricular Function, Left

Intravenous digoxin induces constriction of normal and stenotic coronary arteries in patients with coronary artery disease, which may lead to ischemic complications. We found that pretreatment with oral nisoldipine and intracoronary nitroglycerin neutralizes this digoxin-induced effect.

Topics: Acetyldigoxins; Calcium Channel Blockers; Cardiotonic Agents; Coronary Angiography; Coronary Disease; Coronary Vasospasm; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nisoldipine; Nitroglycerin; Treatment Outcome; Vasoconstriction; Vasodilator Agents

Topics: Acetyldigoxins; Adult; Aged; Coronary Disease; Digoxin; Female; Heart Failure; Humans; Male; Middle Aged

The activity of the beta-receptor blocker pindolol (0.4 mg i.v.) was investigated alone and in combination with digitalis (moderately fast loading) in 12 patients with coronary heart disease and without manifest signs of cardiac insufficiency. These patients showed pathological increase of left ventricular filling pressure during exercise testing. The exercise-induced rise of the mean pulmonary arterial and capillary pressures were increased by pindolol. Concurrently the increase of cardiac frequency was clearly diminished during ergometry (from 107/min without pindolol to 96/min, P less than 0.005). Digoxin given orally for an average of 5 days prevented the pressure increase in the pulmonary circulation induced by pindolol during exercise testing and at rest. The frequency reducing effect of pindolol was potentiated by digitalis. Use of digitalis alone did not influence mean exercise-induced pressure increase of the pulmonary circulation. In fact in some cases deterioration of these parameters was observed.

Topics: Acetyldigoxins; Aged; Blood Pressure; Capillaries; Coronary Disease; Digoxin; Drug Interactions; Female; Humans; Lung; Male; Middle Aged; Pindolol; Pulmonary Artery

Topics: Acetyldigoxins; Adult; Aged; Blood Pressure; Coronary Disease; Digoxin; Drug Combinations; Female; Heart Rate; Humans; Male; Middle Aged; Oxyfedrine; Propiophenones; Time Factors