berberine has been researched along with TDP-43 Proteinopathies in 1 studies
TDP-43 Proteinopathies: Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we studied the molecular mechanism of berberine in cell culture model with TDP-43 proteinopathies, and found that berberine is able to reverse the processing of insoluble TDP-43 aggregates formation through deregulation of mTOR/p70S6K signal and activation of autophagic degradation pathway." | 3.83 | Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS. ( Chang, CF; Chen, CL; Huang, CC; Lee, KH; Lee, YC; Lin, HC; Shen, CJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CF | 1 |
| Lee, YC | 1 |
| Lee, KH | 1 |
| Lin, HC | 1 |
| Chen, CL | 1 |
| Shen, CJ | 1 |
| Huang, CC | 1 |
1 other study available for berberine and TDP-43 Proteinopathies
| Article | Year |
|---|---|
Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Berberine; Cell Line, Tumor; Frontotemporal Lobar Degenerati | 2016 |