Page last updated: 2024-10-23

berberine and Pulmonary Hypertension

berberine has been researched along with Pulmonary Hypertension in 5 studies

Research Excerpts

ExcerptRelevanceReference
"Remodeling of the pulmonary artery is a major feature of pulmonary artery hypertension, and CPU86017, a derivative of berberine, is known to effectively alleviate hypoxic pulmonary hypertension (HPH)."3.74CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. ( Dai, DZ; Dai, Y; Li, N, 2008)
" The present study was conducted to examine the effects of a novel compound p-chlorobenzyltetrahydroberberine (CPU 86017) on endothelin-1 system of hypoxia-induced pulmonary hypertension in rats."3.73Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway. ( Cui, B; Dai, DZ; Tang, XY; Zhang, TT, 2005)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Wande, Y1
Jie, L1
Aikai, Z1
Yaguo, Z1
Linlin, Z1
Yue, G1
Hang, Z1
Luo, J1
Gu, Y1
Liu, P1
Jiang, X1
Yu, W1
Ye, P1
Chao, Y1
Yang, H1
Zhu, L1
Zhou, L1
Chen, S1
Li, N1
Dai, DZ3
Dai, Y1
Zhang, TT2
Cui, B2
Su, W1
Tang, XY1

Other Studies

5 other studies available for berberine and Pulmonary Hypertension

ArticleYear
Berberine alleviates pulmonary hypertension through Trx1 and β-catenin signaling pathways in pulmonary artery smooth muscle cells.
    Experimental cell research, 2020, 05-01, Volume: 390, Issue:1

    Topics: Animals; Berberine; beta Catenin; Cell Proliferation; Cells, Cultured; Humans; Hypertension, Pulmona

2020
Berberine attenuates pulmonary arterial hypertension via protein phosphatase 2A signaling pathway both in vivo and in vitro.
    Journal of cellular physiology, 2018, Volume: 233, Issue:12

    Topics: Animals; Apoptosis; Berberine; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expre

2018
CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:5

    Topics: Animals; Berberine; Extracellular Matrix; Gene Expression Regulation; Hypertension, Pulmonary; Hypox

2008
CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:11

    Topics: Animals; Berberine; Blood Pressure; Calcium Channel Blockers; Endothelin-1; Hypertension, Pulmonary;

2005
Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway.
    Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:6

    Topics: Animals; Antioxidants; Berberine; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelin-1;

2005