Page last updated: 2024-10-23

berberine and Neurodegenerative Diseases

berberine has been researched along with Neurodegenerative Diseases in 17 studies

Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Research Excerpts

ExcerptRelevanceReference
"Neurodegenerative disorders are heterogeneous diseases associated with either acute or progressive neurodegeneration, causing the loss of neurons and axons in the central nervous system (CNS), showing high morbidity and mortality, and there are only a few effective therapies."6.66AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases. ( Fang, Y; Gong, Y; Guo, Y; Huang, J; Li, S; Li, W; Liu, Y; Qin, S; Tang, H; Wang, S; Xu, Z; Yuan, W, 2020)
"Neurodegenerative diseases are among the most serious health problems affecting millions of people worldwide."6.61Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential. ( Cao, M; Fan, D; Liu, L; Wu, Z, 2019)
"Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine."6.52Therapeutic potential of berberine against neurodegenerative diseases. ( Jiang, W; Li, S; Li, X, 2015)
"Demethyleneberberine is a metabolite of berberine that has better blood-brain barrier crossing capacity."2.82Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight. ( Grewal, AK; Gupta, S; Khan, H; Saklani, P; Singh, TG, 2022)
"Berberine is an isoquinoline alkaloid that has shown promise as a pharmacological treatment in PD, given its ability to modulate several molecular pathway associated with the disease."2.82Can Berberine Serve as a New Therapy for Parkinson's Disease? ( Aschner, M; Dadgostar, E; Khandan, M; Mirzaei, H; Moghanlou, M; Mohammadi, S; Parvaresh, M; Tamtaji, OR, 2022)
"Neurodegenerative disorders are heterogeneous diseases associated with either acute or progressive neurodegeneration, causing the loss of neurons and axons in the central nervous system (CNS), showing high morbidity and mortality, and there are only a few effective therapies."2.66AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases. ( Fang, Y; Gong, Y; Guo, Y; Huang, J; Li, S; Li, W; Liu, Y; Qin, S; Tang, H; Wang, S; Xu, Z; Yuan, W, 2020)
"Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity."2.66Biological Activity of Berberine-A Summary Update. ( Nowak, R; Och, A; Podgórski, R, 2020)
"Neurodegenerative diseases are among the most serious health problems affecting millions of people worldwide."2.61Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential. ( Cao, M; Fan, D; Liu, L; Wu, Z, 2019)
"Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine."2.52Therapeutic potential of berberine against neurodegenerative diseases. ( Jiang, W; Li, S; Li, X, 2015)
"Berberine is an isoquinoline alkaloid, widely present in different medicinal herbs, especially in the genus Berberis."2.52Berberine and neurodegeneration: A review of literature. ( Abdollahi, M; Ahmed, T; Daglia, M; Gilani, AU; Nabavi, SF; Nabavi, SM, 2015)
"Berberine (BBR) is a natural alkaloid extracted from the herb Coptis chinensis."1.91Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice. ( Chen, J; Chen, M; Feng, W; Li, X; Li, Y; Liu, Q; Liu, X; Tian, J; Wang, C, 2023)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's6 (35.29)24.3611
2020's10 (58.82)2.80

Authors

AuthorsStudies
Saklani, P1
Khan, H1
Singh, TG1
Gupta, S2
Grewal, AK1
Dadgostar, E1
Moghanlou, M1
Parvaresh, M1
Mohammadi, S1
Khandan, M1
Aschner, M1
Mirzaei, H1
Tamtaji, OR1
Islam, F1
Islam, MM1
Khan Meem, AF1
Nafady, MH1
Islam, MR1
Akter, A1
Mitra, S1
Alhumaydhi, FA1
Emran, TB1
Khusro, A1
Simal-Gandara, J1
Eftekhari, A1
Karimi, F1
Baghayeri, M1
Shen, R3
Chen, Y5
Li, X5
Wang, X3
Yang, A3
Kou, X3
Chen, J2
Feng, W1
Wang, C1
Chen, M1
Li, Y2
Liu, X1
Liu, Q1
Tian, J1
Qin, S1
Tang, H1
Li, W1
Gong, Y1
Li, S2
Huang, J1
Fang, Y1
Yuan, W1
Liu, Y1
Wang, S1
Guo, Y2
Xu, Z1
Och, A1
Podgórski, R1
Nowak, R1
Liang, Y1
Ye, C1
Diao, S1
Huang, M1
Khan, A1
Vishwas, S1
Gulati, M1
Gurjeet Singh, T1
Dua, K1
Kumar Singh, S1
Najda, A1
Sayed, AA1
Almeer, R1
Abdel-Daim, MM1
Mohi-Ud-Din, R1
Mir, RH1
Wani, TU1
Shah, AJ1
Banday, N1
Pottoo, FH1
McCubrey, JA1
Lertpiriyapong, K1
Steelman, LS1
Abrams, SL1
Cocco, L1
Ratti, S1
Martelli, AM1
Candido, S1
Libra, M1
Montalto, G1
Cervello, M1
Gizak, A1
Rakus, D1
Fan, D1
Liu, L1
Wu, Z1
Cao, M1
Soudi, SA1
Nounou, MI1
Sheweita, SA1
Ghareeb, DA1
Younis, LK1
El-Khordagui, LK1
Liu, P1
Qi, X1
Xu, J1
Liu, D1
Ji, X1
Chi, T1
Liu, H1
Zou, L1
Jiang, W1
Ahmed, T1
Gilani, AU1
Abdollahi, M1
Daglia, M1
Nabavi, SF1
Nabavi, SM1
Zhang, J1
Yang, JQ1
He, BC1
Zhou, QX1
Yu, HR1
Tang, Y1
Liu, BZ1

Reviews

10 reviews available for berberine and Neurodegenerative Diseases

ArticleYear
Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight.
    Molecular biology reports, 2022, Volume: 49, Issue:10

    Topics: Alkaloids; AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Antioxidants; Berberine; Humans;

2022
Can Berberine Serve as a New Therapy for Parkinson's Disease?
    Neurotoxicity research, 2022, Volume: 40, Issue:4

    Topics: alpha-Synuclein; Autophagy; Berberine; Dopaminergic Neurons; Humans; Neurodegenerative Diseases; Oxi

2022
Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases.
    Chemosphere, 2022, Volume: 307, Issue:Pt 3

    Topics: Berberine; Curcumin; Genistein; Humans; Luteolin; Neurodegenerative Diseases; Nitrogen; Oxygen; Poly

2022
AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases.
    Current pharmaceutical design, 2020, Volume: 26, Issue:39

    Topics: AMP-Activated Protein Kinases; Autophagy; Berberine; Humans; Neurodegenerative Diseases; Phosphatidy

2020
Biological Activity of Berberine-A Summary Update.
    Toxins, 2020, 11-12, Volume: 12, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Berberine; Cardiovascular Diseases; Drug R

2020
Berberine in the Treatment of Neurodegenerative Diseases and Nanotechnology Enabled Targeted Delivery.
    Combinatorial chemistry & high throughput screening, 2022, Volume: 25, Issue:4

    Topics: Animals; Apoptosis; Berberine; Mice; Nanotechnology; Neurodegenerative Diseases; Reactive Oxygen Spe

2022
Regulation of GSK-3 activity by curcumin, berberine and resveratrol: Potential effects on multiple diseases.
    Advances in biological regulation, 2017, Volume: 65

    Topics: Berberine; Cardiovascular Diseases; Curcumin; Gene Expression Regulation; Glycogen Synthase Kinase 3

2017
Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential.
    Current neuropharmacology, 2019, Volume: 17, Issue:6

    Topics: Animals; Apoptosis; Autophagy; Berberine; Humans; Neurodegenerative Diseases; Neurons; Oxidative Str

2019
Therapeutic potential of berberine against neurodegenerative diseases.
    Science China. Life sciences, 2015, Volume: 58, Issue:6

    Topics: Alzheimer Disease; Animals; Berberine; Blood-Brain Barrier; Disease Models, Animal; Humans; Medicine

2015
Berberine and neurodegeneration: A review of literature.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:5

    Topics: Animals; Antioxidants; Berberine; Berberis; Humans; Neurodegenerative Diseases; Oxidative Stress

2015

Other Studies

7 other studies available for berberine and Neurodegenerative Diseases

ArticleYear
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
    International journal of pharmaceutics, 2023, Jan-05, Volume: 630

    Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod

2023
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
    International journal of pharmaceutics, 2023, Jan-05, Volume: 630

    Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod

2023
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
    International journal of pharmaceutics, 2023, Jan-05, Volume: 630

    Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod

2023
Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.
    International journal of pharmaceutics, 2023, Jan-05, Volume: 630

    Topics: Alzheimer Disease; Animals; Berberine; Caenorhabditis elegans; Drugs, Chinese Herbal; Humans; Neurod

2023
Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 118

    Topics: Alzheimer Disease; Animals; Berberine; Brain; Ferroptosis; Iron; Kelch-Like ECH-Associated Protein 1

2023
Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of β-Amyloid Production and Endoplasmic Reticulum Stress.
    ACS chemical neuroscience, 2021, 06-02, Volume: 12, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Ac

2021
Demethyleneberberine: A possible treatment for Huntington's disease.
    Medical hypotheses, 2021, Volume: 153

    Topics: Berberine; Humans; Huntington Disease; Neurodegenerative Diseases; Oxidative Stress

2021
Protective effect of surface-modified berberine nanoparticles against LPS-induced neurodegenerative changes: a preclinical study.
    Drug delivery and translational research, 2019, Volume: 9, Issue:5

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Berberine; Brain; Chitosan; Glucose; Glutathio

2019
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:9

    Topics: Animals; Berberine; Cognitive Dysfunction; Disease Models, Animal; Glutamic Acid; Glycogen Synthase

2019
Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease.
    Saudi medical journal, 2009, Volume: 30, Issue:6

    Topics: Aluminum; Animals; Berberine; Brain Injuries; Disease Models, Animal; Drugs, Chinese Herbal; Male; N

2009