Page last updated: 2024-10-23

berberine and Melanoma

berberine has been researched along with Melanoma in 12 studies

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration."7.83Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016)
"Melanoma is the most lethal form of skin cancer, and its incidence has increased considerably in the last decades."5.72Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells. ( Assmann, CE; Bianchin, NB; das Neves Oliveira, M; de Andrade, CM; de Oliveira, JS; Morsch, VM; Palma, TV; Pillat, MM; Schetinger, MRC; Ulrich, H, 2022)
"Berberine is an isoquinoline alkaloid, which has been reported to show high photosensitizing activity."5.62Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways. ( Fang, J; Gong, Q; Huang, X; Liang, X; Liu, J; Song, C; Wang, X; Yang, Y, 2021)
"Malignant melanoma is a critical and aggressive skin tumor with a steeply rising incidence and a less favorable prognosis due to the lack of efficient treatment."5.62Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells. ( Fang, J; Huang, X; Liang, X; Liu, J; Wang, X; Yang, Y, 2021)
"In this study, we investigated the anti-metastasis mechanisms of berberine in human melanoma cancer A375."5.48Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro. ( Chueh, FS; Chung, JG; Huang, AC; Huang, WW; Huang, YP; Lai, KC; Liu, JF; Maraming, P; Peng, SF, 2018)
"Berberine (BBR) is a naturally occurring alkaloid compound that can be found in Chinese medicinal herbs such as Rhizoma Coptidis and Phellodendri Cortex."5.46Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine. ( Fu, XQ; Guo, H; Li, T; Liu, B; Liu, SM; Su, T; Tse, AK; Yu, ZL; Zhu, PL, 2017)
" Herein, we studied the anticancer effects of berberine, a plant alkaloid, in combination with doxorubicin on murine melanoma B16F10 cells in vitro and in vivo."5.40Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft. ( Mittal, A; Singh, RP; Tabasum, S, 2014)
"Malignant melanoma is the most aggressive form of skin cancer."5.39Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells. ( Cao, Z; Guo, P; Liu, R; Pan, Y; Yang, P; Zhang, G; Zhou, Q, 2013)
"Melanoma is the leading cause of death from skin disease due, in large part, to its propensity to metastasize."5.37Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors. ( Katiyar, N; Katiyar, SK; Sharma, S; Singh, T; Vaid, M, 2011)
"Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration."3.83Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells. ( Du, B; Kou, Y; Li, B; Li, H; Li, L; Tan, Y; Wang, K, 2016)
"Melanoma is the most lethal form of skin cancer, and its incidence has increased considerably in the last decades."1.72Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells. ( Assmann, CE; Bianchin, NB; das Neves Oliveira, M; de Andrade, CM; de Oliveira, JS; Morsch, VM; Palma, TV; Pillat, MM; Schetinger, MRC; Ulrich, H, 2022)
"Berberine is an isoquinoline alkaloid, which has been reported to show high photosensitizing activity."1.62Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways. ( Fang, J; Gong, Q; Huang, X; Liang, X; Liu, J; Song, C; Wang, X; Yang, Y, 2021)
"In this study, we investigated the anti-metastasis mechanisms of berberine in human melanoma cancer A375."1.48Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro. ( Chueh, FS; Chung, JG; Huang, AC; Huang, WW; Huang, YP; Lai, KC; Liu, JF; Maraming, P; Peng, SF, 2018)
"Malignant melanoma has exhibited a rising incidence in recent years worldwide."1.46Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma. ( Hayakawa, Y; Saiki, I; Xu, X; Yokoyama, S, 2017)
"Berberine (BBR) is a naturally occurring alkaloid compound that can be found in Chinese medicinal herbs such as Rhizoma Coptidis and Phellodendri Cortex."1.46Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine. ( Fu, XQ; Guo, H; Li, T; Liu, B; Liu, SM; Su, T; Tse, AK; Yu, ZL; Zhu, PL, 2017)
" Herein, we studied the anticancer effects of berberine, a plant alkaloid, in combination with doxorubicin on murine melanoma B16F10 cells in vitro and in vivo."1.40Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft. ( Mittal, A; Singh, RP; Tabasum, S, 2014)
"Malignant melanoma is the most aggressive form of skin cancer."1.39Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells. ( Cao, Z; Guo, P; Liu, R; Pan, Y; Yang, P; Zhang, G; Zhou, Q, 2013)
"Melanoma is the leading cause of death from skin disease due, in large part, to its propensity to metastasize."1.37Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors. ( Katiyar, N; Katiyar, SK; Sharma, S; Singh, T; Vaid, M, 2011)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (75.00)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Palma, TV1
Bianchin, NB1
de Oliveira, JS1
Assmann, CE1
das Neves Oliveira, M1
Schetinger, MRC1
Morsch, VM1
Ulrich, H1
Pillat, MM1
de Andrade, CM1
Wang, X2
Gong, Q1
Song, C1
Fang, J2
Yang, Y2
Liang, X2
Huang, X2
Liu, J2
Xu, X1
Yokoyama, S1
Hayakawa, Y1
Saiki, I1
Liu, B1
Fu, XQ1
Li, T1
Su, T1
Guo, H1
Zhu, PL1
Tse, AK1
Liu, SM1
Yu, ZL1
Liu, JF1
Lai, KC1
Peng, SF1
Maraming, P1
Huang, YP1
Huang, AC1
Chueh, FS1
Huang, WW1
Chung, JG1
Liu, R1
Cao, Z1
Pan, Y1
Zhang, G1
Yang, P1
Guo, P1
Zhou, Q1
Mittal, A1
Tabasum, S1
Singh, RP1
Luo, Z1
Zeng, W1
Tang, W1
Long, T1
Zhang, J1
Xie, X1
Kuang, Y1
Chen, M1
Su, J1
Chen, X1
Kou, Y1
Li, L1
Li, H1
Tan, Y1
Li, B1
Wang, K1
Du, B1
Singh, T1
Vaid, M1
Katiyar, N1
Sharma, S1
Katiyar, SK1
Burgeiro, A1
Gajate, C1
Dakir, el H1
Villa-Pulgarín, JA1
Oliveira, PJ1
Mollinedo, F1

Other Studies

12 other studies available for berberine and Melanoma

ArticleYear
Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells.
    Molecular biology reports, 2022, Volume: 49, Issue:3

    Topics: Apoptosis; Berberine; Cell Line, Tumor; Cytokines; Humans; Melanoma

2022
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways.
    Toxicology and applied pharmacology, 2021, 05-01, Volume: 418

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Berberine; Cell Line, Tumor; Cell P

2021
Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells.
    Biochemical and biophysical research communications, 2021, 05-07, Volume: 552

    Topics: Apoptosis; Autophagy; Berberine; Blotting, Western; Cell Line, Tumor; Endoplasmic Reticulum Stress;

2021
Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.
    Oncology reports, 2017, Volume: 38, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonis

2017
Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine.
    Journal of ethnopharmacology, 2017, Aug-17, Volume: 208

    Topics: Antineoplastic Agents; Berberine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydroorotat

2017
Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro.
    Molecules (Basel, Switzerland), 2018, Aug-13, Volume: 23, Issue:8

    Topics: Berberine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Drug Resistance, Neop

2018
Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells.
    Anti-cancer drugs, 2013, Volume: 24, Issue:7

    Topics: Animals; Berberine; Cell Line, Tumor; Growth Inhibitors; Humans; Melanoma; Mice; Mice, Inbred BALB C

2013
Berberine in combination with doxorubicin suppresses growth of murine melanoma B16F10 cells in culture and xenograft.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, Feb-15, Volume: 21, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Caspase 3; Cell Cycle; Cell Line,

2014
CD147 interacts with NDUFS6 in regulating mitochondrial complex I activity and the mitochondrial apoptotic pathway in human malignant melanoma cells.
    Current molecular medicine, 2014, Volume: 14, Issue:10

    Topics: Apoptosis; Basigin; Berberine; Cell Line, Tumor; Cell Nucleus; Electron Transport Complex I; Gene Ex

2014
Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells.
    Biochemical and biophysical research communications, 2016, Oct-14, Volume: 479, Issue:2

    Topics: Animals; Antineoplastic Agents; Berberine; Chromones; Epithelial-Mesenchymal Transition; Gene Expres

2016
Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors.
    Carcinogenesis, 2011, Volume: 32, Issue:1

    Topics: Antineoplastic Agents; Berberine; Blotting, Western; Cell Line, Tumor; Cell Movement; Cyclooxygenase

2011
Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.
    Anti-cancer drugs, 2011, Volume: 22, Issue:6

    Topics: Adenine Nucleotides; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Blotting, Western; Cas

2011