Page last updated: 2024-10-23

berberine and Lung Neoplasms

berberine has been researched along with Lung Neoplasms in 51 studies

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"The present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the perspective of senescence and inflammation using human non-small cell lung cancer cell line (A549)."7.96Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. ( Awasthi, M; Kumar, R; Padwad, Y; Sharma, A; Sharma, R, 2020)
"We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer."7.71Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. ( Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T, 2001)
"Berberine could suppress the transcription level of Id-1 through inhibiting its promotor activity."5.42Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. ( Cheung, KC; Cheung, YC; Feng, Y; Lui, VW; Man, K; Tsang, CM; Tsao, SW, 2015)
"The present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the perspective of senescence and inflammation using human non-small cell lung cancer cell line (A549)."3.96Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. ( Awasthi, M; Kumar, R; Padwad, Y; Sharma, A; Sharma, R, 2020)
"We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer."3.71Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. ( Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T, 2001)
"Berberine (BBR) is an active alkaloid extracted from pharmaceutical plants such as Coptis chinensis."1.91Antitumor effects of erlotinib in combination with berberine in A431 cells. ( Cuan, X; Huang, Y; Luo, R; Sheng, J; Wang, X; Yang, X; Zhao, Y; Zhu, W, 2023)
"Berberine is a natural product that has long been used in traditional Chinese medicine due to its antimicrobial, anti-inflammatory and metabolism-regulatory properties."1.72The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition. ( Chen, H; Chen, Z; Ramalingam, SS; Sun, SY; Vallega, KA; Zhou, J, 2022)
"Berberine is an isoquinoline alkaloid which offers a broad range of therapeutical and pharmacological actions against cancer."1.72Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro. ( Chellappan, DK; Dua, K; Gupta, G; Gupta, PK; Hansbro, PM; Jha, NK; Kumar, P; MacLoughlin, R; Madheswaran, T; Malyla, V; Mehta, M; Oliver, BG; Panneerselvam, J; Patel, VK; Paudel, KR; Singh, SK; Yen, LL; Yin, GHS, 2022)
"Lung cancer is one of the most common types of malignant tumors of the respiratory system and has the highest rates of incidence and mortality of malignant tumors."1.72Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer. ( Abdel-Wahhab, MA; Badawy, AM; Badawy, EA; El-Bana, MA; El-Dosoky, MA; Farrag, AE; Mahmoud, MA; Morsy, SM, 2022)
"Berberine (BBR) is a major bioactive compound in CCF and may exert anti-tumor and anti-inflammatory effects like CCF."1.72Berberine regulates PADI4-related macrophage function to prevent lung cancer. ( Du, G; Gao, F; Gu, W; Guo, Z; Li, W; Niu, Y; Sun, L; Xia, H; Zhang, M; Zhang, Y, 2022)
"Berberine has been increasingly popular in colorectal cancer treatment, but little is known about its bioactivity against non-small cell lung cancer (NSCLC)."1.72Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis. ( Chen, X; Kong, L; Li, J; Li, Z; Ni, L; Ning, B; Ren, H; Xiong, M; Zhang, X, 2022)
"Berberine has been found to have potent anticancer activities via distinct molecular mechanism."1.62Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis. ( Chen, K; Chen, P; Dai, CH; Li, J; Shi, ZH; Su, JY; Wang, Y; Wu, JN, 2021)
"Demethyleneberberine (DMB) is a natural active component of medicinal plant Cortex phellodendri chinensis with favorable bioactivity."1.62Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway. ( Chen, J; Huang, X; Ji, K; Liu, D; Liu, J; Tao, C; Zhang, R, 2021)
"Berberine has been illustrated to be a therapeutic agent of NSCLC."1.56Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells. ( Chang, JM; Chao, WY; Chen, SH; Chung, HC; Kam, KH; Lee, YR; Li, YZ; Wu, JY; Zhao, PW, 2020)
"Etoposide (ETP), as a potential treatment for lung cancer, has limited application due to its poor solubility, and systemic side effects."1.48Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. ( Abdelfattah, EA; Elgohary, MM; Elzoghby, AO; Fang, JY; Helmy, MW; Mortada, SM; Ragab, DM, 2018)
"Treatment with melatonin effectively increased the berberine-mediated inhibitions of cell proliferation, colony formation and cell migration, thereby enhancing the sensitivities of lung cancer cells to berberine."1.43Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. ( Deng, W; Fu, L; Huang, W; Lu, JJ; Qin, L; Shi, D; Tang, Z; Wang, J; Xiao, X; Xie, F; Yu, Z; Zhang, C, 2016)
"Berberine could suppress the transcription level of Id-1 through inhibiting its promotor activity."1.42Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. ( Cheung, KC; Cheung, YC; Feng, Y; Lui, VW; Man, K; Tsang, CM; Tsao, SW, 2015)
"The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use."1.40Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. ( Doddapaneni, R; Godugu, C; Patel, AR; Singh, M; Somagoni, J, 2014)
"Berberine can inhibit the activity of N-acetyltransferase in human lung cancer cell line A549, and shows negative correlations of dose and time in a certain extent."1.40Effect of berberine on activity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549. ( Chuang, K; Chuang, Y; Chung, J; Fang, K; Lee, Y; Xi, S, 2014)
"Berberine treatment also decreased various biochemical parameters associated with lung metastasis."1.38Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells. ( Hamsa, TP; Kuttan, G, 2012)
" Demonstration of oral bioavailability and anti-tumorigenic efficacy of dietary berberine, as well as further demonstration of signaling pathway modulation and cell-cycle arrest, implicate this relatively safe, natural compound as a potentially important therapeutic and chemopreventive agent for lung cancer."1.37Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. ( Chen, DR; Fu, H; James, MA; Liu, Y; You, M, 2011)
"Berberine could inhibit the expression of cyclin D1 in PG cells."1.35Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. ( Deng, WW; Hao, Y; Li, N; Luo, Y; Shi, TP, 2008)
"Berberine has been shown to have anti-carcinogenic effects."1.35p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. ( Akhtar, S; Katiyar, N; Katiyar, SK; Meeran, SM, 2009)

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (15.69)29.6817
2010's23 (45.10)24.3611
2020's20 (39.22)2.80

Authors

AuthorsStudies
Chen, P1
Dai, CH1
Shi, ZH1
Wang, Y1
Wu, JN1
Chen, K1
Su, JY1
Li, J4
Chen, Z2
Vallega, KA1
Chen, H1
Zhou, J1
Ramalingam, SS1
Sun, SY1
Paudel, KR2
Mehta, M1
Yin, GHS1
Yen, LL1
Malyla, V2
Patel, VK1
Panneerselvam, J1
Madheswaran, T1
MacLoughlin, R1
Jha, NK1
Gupta, PK1
Singh, SK1
Gupta, G1
Kumar, P1
Oliver, BG1
Hansbro, PM2
Chellappan, DK2
Dua, K2
Mahmoud, MA1
El-Bana, MA1
Morsy, SM1
Badawy, EA1
Farrag, AE1
Badawy, AM1
Abdel-Wahhab, MA1
El-Dosoky, MA1
Gu, W1
Zhang, M2
Gao, F1
Niu, Y1
Sun, L1
Xia, H1
Li, W1
Zhang, Y3
Guo, Z1
Du, G1
Tang, Q3
Liang, B1
Zhang, L1
Li, X3
Li, H2
Jing, W1
Jiang, Y1
Zhou, F1
Zhang, J1
Meng, Y1
Yang, X3
Yang, H1
Huang, G1
Zhao, J1
Achi, IT1
Sarbadhikary, P1
George, BP1
Abrahamse, H1
Wang, Q1
Wu, H1
Wu, Q1
Zhong, S1
Cuan, X1
Zhu, W2
Zhao, Y3
Luo, R1
Huang, Y1
Wang, X1
Sheng, J1
De Rubis, G1
Hansbro, NG1
Uma Maheswari, RT1
Ajithkumar, V1
Varalakshmi, P1
Rajan, M1
Xu, L1
Kumar, R1
Awasthi, M1
Sharma, A1
Padwad, Y1
Sharma, R1
Zheng, F2
Ma, C1
Tang, X1
Wu, J3
Chai, X1
Xie, J1
Yang, XB1
Hann, SS1
Chang, JM1
Kam, KH1
Chao, WY1
Zhao, PW1
Chen, SH1
Chung, HC1
Li, YZ1
Wu, JY1
Lee, YR1
Chen, J2
Huang, X2
Tao, C2
Wang, L1
Zeng, Q1
Ma, M1
Zhang, R2
Wu, Z1
Liu, X1
Zhou, GJ1
Hou, Y1
Kong, Q1
Lu, JJ2
Zhang, Q1
Chen, X2
Zheng, X1
Jia, Y1
Shao, D1
Zhang, F1
Sun, M1
Dawulieti, J1
Hu, H2
Cui, L1
Pan, Y1
Yang, C1
Sun, W1
Zhang, S1
He, K1
Du, J1
Chen, L2
Liu, J1
Liu, D1
Ji, K1
Ni, L1
Li, Z2
Ren, H1
Kong, L1
Xiong, M1
Zhang, X2
Ning, B1
Dai, B1
Ma, Y1
Wang, W1
Zhan, Y1
Zhang, D1
Liu, R1
Wang, YX1
Pang, WQ1
Zeng, QX1
Deng, ZS1
Fan, TY1
Jiang, JD1
Deng, HB1
Song, DQ1
Xiao, Y1
Tian, C1
Huang, T2
Han, B1
Wang, M1
Ma, H1
Ye, X1
Kim, S1
Lee, J1
You, D1
Jeong, Y1
Jeon, M1
Yu, J1
Kim, SW1
Nam, SJ1
Lee, JE1
Kabary, DM2
Helmy, MW4
Elkhodairy, KA2
Fang, JY3
Elzoghby, AO4
Abdelfattah, EA2
Elgohary, MM2
Ragab, DM1
Mortada, SM2
Yao, Z1
Wan, Y1
Li, B1
Zhai, C1
Yao, F1
Kang, Y1
Liu, Q1
Lin, D1
Song, J1
Lin, C1
Xie, Y2
Hu, P1
Fu, L2
Chen, W1
Guo, W1
Wang, J2
Tian, Y1
Shi, D2
Qiu, H1
Xiao, X2
Kang, T1
Huang, W2
Wang, S1
Deng, W2
Qi, HW1
Xin, LY1
Xu, X1
Ji, XX1
Fan, LH1
Godugu, C1
Patel, AR1
Doddapaneni, R1
Somagoni, J1
Singh, M1
Zhao, S1
Liang, Z1
Li, L2
Wu, W1
Hann, S1
Xi, S1
Chuang, K1
Fang, K1
Lee, Y1
Chung, J1
Chuang, Y1
Tsang, CM1
Cheung, KC1
Cheung, YC1
Man, K1
Lui, VW1
Tsao, SW1
Feng, Y1
Yang, J1
Zheng, M1
Kong, X1
Cai, YD1
Jiang, G1
Wu, X1
Dong, S1
Tong, X1
Yuan, ZW1
Leung, EL1
Fan, XX1
Zhou, H1
Ma, WZ1
Liu, L1
Zhu, T1
Li, LL1
Xiao, GF1
Luo, QZ1
Liu, QZ1
Yao, KT1
Xiao, GH1
Tang, Z1
Zhang, C2
Qin, L1
Yu, Z1
Xie, F1
Liu, Y2
Yu, H1
Cheng, Y1
Hu, L1
Meng, X1
James, MA1
Fu, H1
Chen, DR1
You, M1
Hamsa, TP1
Kuttan, G1
Peng, PL2
Hsieh, YS1
Wang, CJ1
Hsu, JL1
Chou, FP2
Kuo, WH1
Tseng, HC1
Hao, Y2
Wang, P1
Qiu, QY1
Luo, Y1
Shi, TP1
Deng, WW1
Li, N1
Katiyar, SK1
Meeran, SM1
Katiyar, N1
Akhtar, S1
Mitani, N1
Murakami, K1
Yamaura, T1
Ikeda, T1
Saiki, I1
Iwasa, K1
Moriyasu, M1
Yamori, T1
Turuo, T1
Lee, DU1
Wiegrebe, W1

Reviews

1 review available for berberine and Lung Neoplasms

ArticleYear
Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment.
    Cells, 2022, 10-31, Volume: 11, Issue:21

    Topics: Antineoplastic Agents; Apoptosis; Berberine; Cell Proliferation; Humans; Lung Neoplasms; Tumor Micro

2022

Trials

1 trial available for berberine and Lung Neoplasms

ArticleYear
Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer.
    European journal of cancer (Oxford, England : 1990), 2008, Volume: 44, Issue:16

    Topics: Aged; Berberine; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Double-Blind Method; Fem

2008

Other Studies

49 other studies available for berberine and Lung Neoplasms

ArticleYear
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis.
    Apoptosis : an international journal on programmed cell death, 2021, Volume: 26, Issue:11-12

    Topics: Animals; Apoptosis; Autophagic Cell Death; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum

2021
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition.
    Pharmacological research, 2022, Volume: 175

    Topics: Acrylamides; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Berberine; Biological Pro

2022
Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:31

    Topics: Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neopla

2022
Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer.
    International journal of pharmaceutics, 2022, Apr-25, Volume: 618

    Topics: Animals; bcl-2-Associated X Protein; Berberine; Caspase 9; Chitosan; Lung Neoplasms; Male; Mice; Nan

2022
Berberine regulates PADI4-related macrophage function to prevent lung cancer.
    International immunopharmacology, 2022, Volume: 110

    Topics: Animals; Apoptosis; Berberine; Epithelial-Mesenchymal Transition; Interferon Regulatory Factors; Lun

2022
Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
    Scientific reports, 2022, 10-17, Volume: 12, Issue:1

    Topics: Animals; Berberine; Breast Neoplasms; Caveolin 1; Cholesterol; Extracellular Traps; Female; Histones

2022
Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway.
    Drug development research, 2023, Volume: 84, Issue:5

    Topics: Animals; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell

2023
Antitumor effects of erlotinib in combination with berberine in A431 cells.
    BMC pharmacology & toxicology, 2023, 05-11, Volume: 24, Issue:1

    Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Erb

2023
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:12

    Topics: Adenocarcinoma of Lung; Berberine; beta Catenin; Catenins; Cell Line, Tumor; Cell Movement; Cell Pro

2023
CD44 tagged hyaluronic acid - chitosan liposome carrier for the delivery of berberine and doxorubicin into lung cancer cells.
    International journal of biological macromolecules, 2023, Dec-31, Volume: 253, Issue:Pt 2

    Topics: Animals; Berberine; Caenorhabditis elegans; Chitosan; Doxorubicin; Drug Delivery Systems; Humans; Hy

2023
Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining Network Pharmacology, Molecular Docking, and Experimental Verification.
    Critical reviews in immunology, 2023, Volume: 43, Issue:2

    Topics: Autophagy; Berberine; Carcinoma, Non-Small-Cell Lung; Humans; I-kappa B Kinase; Lung Neoplasms; Mole

2023
Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway.
    Life sciences, 2020, Mar-01, Volume: 244

    Topics: A549 Cells; Apoptosis; Berberine; Cell Proliferation; Cellular Senescence; Cyclins; Gene Expression

2020
Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib  leading to inhibition of EMT in human lung cancer.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:10

    Topics: Animals; Apoptosis; Berberine; Cell Line, Tumor; Cell Movement; Cell Survival; Epithelial-Mesenchyma

2020
Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells.
    International journal of molecular sciences, 2020, Jun-13, Volume: 21, Issue:12

    Topics: A549 Cells; Antineoplastic Agents; Berberine; Bromides; Carcinoma, Non-Small-Cell Lung; Cell Cycle;

2020
Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo.
    Cancer chemotherapy and pharmacology, 2020, Volume: 86, Issue:1

    Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Carcinoma, Non-Small-C

2020
Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad3.
    Toxicology and applied pharmacology, 2020, 10-01, Volume: 404

    Topics: Animals; Antineoplastic Agents; Berberine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Epithelia

2020
Biomimetic co-assembled nanodrug of doxorubicin and berberine suppresses chemotherapy-exacerbated breast cancer metastasis.
    Biomaterials, 2021, Volume: 271

    Topics: Animals; Berberine; Biomimetics; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Humans; Lung Neopl

2021
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 91

    Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cellul

2021
Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis.
    Clinical and experimental pharmacology & physiology, 2022, Volume: 49, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum

2022
Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators.
    Journal of cellular and molecular medicine, 2017, Volume: 21, Issue:10

    Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Berberin

2017
Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Berberine; Cell Survival; Dose-Response Relationship, Drug; Humans; Immunotherapy; Indoleamine-Pyrro

2018
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
    Life sciences, 2018, Jan-01, Volume: 192

    Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Biomarkers, Tumor; Bod

2018
Berberine Suppresses Cell Motility Through Downregulation of TGF-β1 in Triple Negative Breast Cancer Cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:2

    Topics: Animals; Benzamides; Berberine; Cell Line, Tumor; Cell Movement; Databases, Factual; Dioxoles; Down-

2018
Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma.
    Colloids and surfaces. B, Biointerfaces, 2018, 09-01, Volume: 169

    Topics: A549 Cells; Animals; Antineoplastic Agents; Berberine; Cell Proliferation; Drug Carriers; Drug Deliv

2018
Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor/herbal combined therapy of lung carcinoma.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 130

    Topics: A549 Cells; Adenocarcinoma; Administration, Inhalation; Animals; Antineoplastic Combined Chemotherap

2018
Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2018, 09-10, Volume: 285

    Topics: A549 Cells; Administration, Inhalation; Animals; Antineoplastic Agents, Phytogenic; Berberine; Boron

2018
Dual-targeted nano-in-nano albumin carriers enhance the efficacy of combined chemo/herbal therapy of lung cancer.
    Nanomedicine (London, England), 2018, Volume: 13, Issue:17

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Berberine; Cell Survival; Drug Carriers; Drug

2018
Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells.
    Oncology reports, 2018, Volume: 40, Issue:6

    Topics: Antineoplastic Agents; Autophagy; Berberine; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell S

2018
Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways.
    Journal of controlled release : official journal of the Controlled Release Society, 2019, 01-28, Volume: 294

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Berberine; Cytochromes c; Drug Delivery Syste

2019
Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tu

2013
Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis.
    Journal of translational medicine, 2014, Jan-24, Volume: 12

    Topics: Animals; Apoptosis; Berberine; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Proliferatio

2014
Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Berberine; Betulinic Acid; Biological Availabi

2014
p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.
    Journal of experimental & clinical cancer research : CR, 2014, Apr-26, Volume: 33

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Berberine; Cell Line, Tumo

2014
Effect of berberine on activity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2014, Volume: 34, Issue:3

    Topics: Berberine; Cell Line, Tumor; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Humans;

2014
Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma.
    Biochimica et biophysica acta, 2015, Volume: 1852, Issue:3

    Topics: Animals; Berberine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression

2015
The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Antineoplastic Agents; Arsenicals; Berberine; Carcinogenesis; Carcinoma, Non-Small-Cell Lun

2015
[Influence of Berberine on Cisplatin Antineoplastic Effect in A549 Cells].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015, Volume: 18, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell

2015
Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS.
    Talanta, 2015, Nov-01, Volume: 144

    Topics: Antineoplastic Agents; Berberine; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Line, T

2015
Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer.
    The American journal of Chinese medicine, 2015, Volume: 43, Issue:7

    Topics: Apoptosis; Berberine; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Coptis

2015
Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells.
    Oncotarget, 2016, Jan-19, Volume: 7, Issue:3

    Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy

2016
Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis.
    Molecular carcinogenesis, 2011, Volume: 50, Issue:1

    Topics: Animals; Berberine; Blotting, Western; Cell Cycle; Cell Proliferation; Diet; Disease Progression; Hu

2011
Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:4

    Topics: Activating Transcription Factor 2; Animals; Antineoplastic Agents, Phytogenic; Berberine; Cell Line,

2012
Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
    Toxicology and applied pharmacology, 2006, Jul-01, Volume: 214, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell

2006
Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death.
    International journal of radiation oncology, biology, physics, 2008, Feb-01, Volume: 70, Issue:2

    Topics: Acridine Orange; Animals; Autophagy; Berberine; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lun

2008
[Effects of ginsenoside and berberine on secretion of immunosuppressive cytokines in lung carcinoma cell line PG].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2008, Volume: 6, Issue:3

    Topics: Apoptosis; Berberine; Coculture Techniques; Dinoprostone; Ginsenosides; Humans; Jurkat Cells; Lung N

2008
Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:5

    Topics: Amino Acid Motifs; Antineoplastic Agents; Berberine; Carcinoma, Giant Cell; Cell Line, Tumor; Cell P

2008
p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo.
    Molecular carcinogenesis, 2009, Volume: 48, Issue:1

    Topics: Animals; Apoptosis; Berberine; Blotting, Western; Bronchi; Carcinoma, Non-Small-Cell Lung; Caspase 3

2009
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
    Cancer letters, 2001, Apr-10, Volume: 165, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Camptothecin; Carcinoma, Lewis L

2001
In vitro cytotoxicity of the protoberberine-type alkaloids.
    Journal of natural products, 2001, Volume: 64, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Berberine; Berberine Alkaloids; Brain Neoplasms; Breast

2001