berberine has been researched along with Lung Neoplasms in 51 studies
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the perspective of senescence and inflammation using human non-small cell lung cancer cell line (A549)." | 7.96 | Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. ( Awasthi, M; Kumar, R; Padwad, Y; Sharma, A; Sharma, R, 2020) |
| "We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer." | 7.71 | Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. ( Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T, 2001) |
| "Berberine could suppress the transcription level of Id-1 through inhibiting its promotor activity." | 5.42 | Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. ( Cheung, KC; Cheung, YC; Feng, Y; Lui, VW; Man, K; Tsang, CM; Tsao, SW, 2015) |
| "The present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the perspective of senescence and inflammation using human non-small cell lung cancer cell line (A549)." | 3.96 | Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway. ( Awasthi, M; Kumar, R; Padwad, Y; Sharma, A; Sharma, R, 2020) |
| "We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer." | 3.71 | Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. ( Ikeda, T; Mitani, N; Murakami, K; Saiki, I; Yamaura, T, 2001) |
| "Berberine (BBR) is an active alkaloid extracted from pharmaceutical plants such as Coptis chinensis." | 1.91 | Antitumor effects of erlotinib in combination with berberine in A431 cells. ( Cuan, X; Huang, Y; Luo, R; Sheng, J; Wang, X; Yang, X; Zhao, Y; Zhu, W, 2023) |
| "Berberine is a natural product that has long been used in traditional Chinese medicine due to its antimicrobial, anti-inflammatory and metabolism-regulatory properties." | 1.72 | The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition. ( Chen, H; Chen, Z; Ramalingam, SS; Sun, SY; Vallega, KA; Zhou, J, 2022) |
| "Berberine is an isoquinoline alkaloid which offers a broad range of therapeutical and pharmacological actions against cancer." | 1.72 | Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro. ( Chellappan, DK; Dua, K; Gupta, G; Gupta, PK; Hansbro, PM; Jha, NK; Kumar, P; MacLoughlin, R; Madheswaran, T; Malyla, V; Mehta, M; Oliver, BG; Panneerselvam, J; Patel, VK; Paudel, KR; Singh, SK; Yen, LL; Yin, GHS, 2022) |
| "Lung cancer is one of the most common types of malignant tumors of the respiratory system and has the highest rates of incidence and mortality of malignant tumors." | 1.72 | Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer. ( Abdel-Wahhab, MA; Badawy, AM; Badawy, EA; El-Bana, MA; El-Dosoky, MA; Farrag, AE; Mahmoud, MA; Morsy, SM, 2022) |
| "Berberine (BBR) is a major bioactive compound in CCF and may exert anti-tumor and anti-inflammatory effects like CCF." | 1.72 | Berberine regulates PADI4-related macrophage function to prevent lung cancer. ( Du, G; Gao, F; Gu, W; Guo, Z; Li, W; Niu, Y; Sun, L; Xia, H; Zhang, M; Zhang, Y, 2022) |
| "Berberine has been increasingly popular in colorectal cancer treatment, but little is known about its bioactivity against non-small cell lung cancer (NSCLC)." | 1.72 | Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis. ( Chen, X; Kong, L; Li, J; Li, Z; Ni, L; Ning, B; Ren, H; Xiong, M; Zhang, X, 2022) |
| "Berberine has been found to have potent anticancer activities via distinct molecular mechanism." | 1.62 | Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis. ( Chen, K; Chen, P; Dai, CH; Li, J; Shi, ZH; Su, JY; Wang, Y; Wu, JN, 2021) |
| "Demethyleneberberine (DMB) is a natural active component of medicinal plant Cortex phellodendri chinensis with favorable bioactivity." | 1.62 | Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway. ( Chen, J; Huang, X; Ji, K; Liu, D; Liu, J; Tao, C; Zhang, R, 2021) |
| "Berberine has been illustrated to be a therapeutic agent of NSCLC." | 1.56 | Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells. ( Chang, JM; Chao, WY; Chen, SH; Chung, HC; Kam, KH; Lee, YR; Li, YZ; Wu, JY; Zhao, PW, 2020) |
| "Etoposide (ETP), as a potential treatment for lung cancer, has limited application due to its poor solubility, and systemic side effects." | 1.48 | Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy. ( Abdelfattah, EA; Elgohary, MM; Elzoghby, AO; Fang, JY; Helmy, MW; Mortada, SM; Ragab, DM, 2018) |
| "Treatment with melatonin effectively increased the berberine-mediated inhibitions of cell proliferation, colony formation and cell migration, thereby enhancing the sensitivities of lung cancer cells to berberine." | 1.43 | Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. ( Deng, W; Fu, L; Huang, W; Lu, JJ; Qin, L; Shi, D; Tang, Z; Wang, J; Xiao, X; Xie, F; Yu, Z; Zhang, C, 2016) |
| "Berberine could suppress the transcription level of Id-1 through inhibiting its promotor activity." | 1.42 | Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma. ( Cheung, KC; Cheung, YC; Feng, Y; Lui, VW; Man, K; Tsang, CM; Tsao, SW, 2015) |
| "The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use." | 1.40 | Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid. ( Doddapaneni, R; Godugu, C; Patel, AR; Singh, M; Somagoni, J, 2014) |
| "Berberine can inhibit the activity of N-acetyltransferase in human lung cancer cell line A549, and shows negative correlations of dose and time in a certain extent." | 1.40 | Effect of berberine on activity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549. ( Chuang, K; Chuang, Y; Chung, J; Fang, K; Lee, Y; Xi, S, 2014) |
| "Berberine treatment also decreased various biochemical parameters associated with lung metastasis." | 1.38 | Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells. ( Hamsa, TP; Kuttan, G, 2012) |
| " Demonstration of oral bioavailability and anti-tumorigenic efficacy of dietary berberine, as well as further demonstration of signaling pathway modulation and cell-cycle arrest, implicate this relatively safe, natural compound as a potentially important therapeutic and chemopreventive agent for lung cancer." | 1.37 | Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. ( Chen, DR; Fu, H; James, MA; Liu, Y; You, M, 2011) |
| "Berberine could inhibit the expression of cyclin D1 in PG cells." | 1.35 | Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif. ( Deng, WW; Hao, Y; Li, N; Luo, Y; Shi, TP, 2008) |
| "Berberine has been shown to have anti-carcinogenic effects." | 1.35 | p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. ( Akhtar, S; Katiyar, N; Katiyar, SK; Meeran, SM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (15.69) | 29.6817 |
| 2010's | 23 (45.10) | 24.3611 |
| 2020's | 20 (39.22) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, P | 1 |
| Dai, CH | 1 |
| Shi, ZH | 1 |
| Wang, Y | 1 |
| Wu, JN | 1 |
| Chen, K | 1 |
| Su, JY | 1 |
| Li, J | 4 |
| Chen, Z | 2 |
| Vallega, KA | 1 |
| Chen, H | 1 |
| Zhou, J | 1 |
| Ramalingam, SS | 1 |
| Sun, SY | 1 |
| Paudel, KR | 2 |
| Mehta, M | 1 |
| Yin, GHS | 1 |
| Yen, LL | 1 |
| Malyla, V | 2 |
| Patel, VK | 1 |
| Panneerselvam, J | 1 |
| Madheswaran, T | 1 |
| MacLoughlin, R | 1 |
| Jha, NK | 1 |
| Gupta, PK | 1 |
| Singh, SK | 1 |
| Gupta, G | 1 |
| Kumar, P | 1 |
| Oliver, BG | 1 |
| Hansbro, PM | 2 |
| Chellappan, DK | 2 |
| Dua, K | 2 |
| Mahmoud, MA | 1 |
| El-Bana, MA | 1 |
| Morsy, SM | 1 |
| Badawy, EA | 1 |
| Farrag, AE | 1 |
| Badawy, AM | 1 |
| Abdel-Wahhab, MA | 1 |
| El-Dosoky, MA | 1 |
| Gu, W | 1 |
| Zhang, M | 2 |
| Gao, F | 1 |
| Niu, Y | 1 |
| Sun, L | 1 |
| Xia, H | 1 |
| Li, W | 1 |
| Zhang, Y | 3 |
| Guo, Z | 1 |
| Du, G | 1 |
| Tang, Q | 3 |
| Liang, B | 1 |
| Zhang, L | 1 |
| Li, X | 3 |
| Li, H | 2 |
| Jing, W | 1 |
| Jiang, Y | 1 |
| Zhou, F | 1 |
| Zhang, J | 1 |
| Meng, Y | 1 |
| Yang, X | 3 |
| Yang, H | 1 |
| Huang, G | 1 |
| Zhao, J | 1 |
| Achi, IT | 1 |
| Sarbadhikary, P | 1 |
| George, BP | 1 |
| Abrahamse, H | 1 |
| Wang, Q | 1 |
| Wu, H | 1 |
| Wu, Q | 1 |
| Zhong, S | 1 |
| Cuan, X | 1 |
| Zhu, W | 2 |
| Zhao, Y | 3 |
| Luo, R | 1 |
| Huang, Y | 1 |
| Wang, X | 1 |
| Sheng, J | 1 |
| De Rubis, G | 1 |
| Hansbro, NG | 1 |
| Uma Maheswari, RT | 1 |
| Ajithkumar, V | 1 |
| Varalakshmi, P | 1 |
| Rajan, M | 1 |
| Xu, L | 1 |
| Kumar, R | 1 |
| Awasthi, M | 1 |
| Sharma, A | 1 |
| Padwad, Y | 1 |
| Sharma, R | 1 |
| Zheng, F | 2 |
| Ma, C | 1 |
| Tang, X | 1 |
| Wu, J | 3 |
| Chai, X | 1 |
| Xie, J | 1 |
| Yang, XB | 1 |
| Hann, SS | 1 |
| Chang, JM | 1 |
| Kam, KH | 1 |
| Chao, WY | 1 |
| Zhao, PW | 1 |
| Chen, SH | 1 |
| Chung, HC | 1 |
| Li, YZ | 1 |
| Wu, JY | 1 |
| Lee, YR | 1 |
| Chen, J | 2 |
| Huang, X | 2 |
| Tao, C | 2 |
| Wang, L | 1 |
| Zeng, Q | 1 |
| Ma, M | 1 |
| Zhang, R | 2 |
| Wu, Z | 1 |
| Liu, X | 1 |
| Zhou, GJ | 1 |
| Hou, Y | 1 |
| Kong, Q | 1 |
| Lu, JJ | 2 |
| Zhang, Q | 1 |
| Chen, X | 2 |
| Zheng, X | 1 |
| Jia, Y | 1 |
| Shao, D | 1 |
| Zhang, F | 1 |
| Sun, M | 1 |
| Dawulieti, J | 1 |
| Hu, H | 2 |
| Cui, L | 1 |
| Pan, Y | 1 |
| Yang, C | 1 |
| Sun, W | 1 |
| Zhang, S | 1 |
| He, K | 1 |
| Du, J | 1 |
| Chen, L | 2 |
| Liu, J | 1 |
| Liu, D | 1 |
| Ji, K | 1 |
| Ni, L | 1 |
| Li, Z | 2 |
| Ren, H | 1 |
| Kong, L | 1 |
| Xiong, M | 1 |
| Zhang, X | 2 |
| Ning, B | 1 |
| Dai, B | 1 |
| Ma, Y | 1 |
| Wang, W | 1 |
| Zhan, Y | 1 |
| Zhang, D | 1 |
| Liu, R | 1 |
| Wang, YX | 1 |
| Pang, WQ | 1 |
| Zeng, QX | 1 |
| Deng, ZS | 1 |
| Fan, TY | 1 |
| Jiang, JD | 1 |
| Deng, HB | 1 |
| Song, DQ | 1 |
| Xiao, Y | 1 |
| Tian, C | 1 |
| Huang, T | 2 |
| Han, B | 1 |
| Wang, M | 1 |
| Ma, H | 1 |
| Ye, X | 1 |
| Kim, S | 1 |
| Lee, J | 1 |
| You, D | 1 |
| Jeong, Y | 1 |
| Jeon, M | 1 |
| Yu, J | 1 |
| Kim, SW | 1 |
| Nam, SJ | 1 |
| Lee, JE | 1 |
| Kabary, DM | 2 |
| Helmy, MW | 4 |
| Elkhodairy, KA | 2 |
| Fang, JY | 3 |
| Elzoghby, AO | 4 |
| Abdelfattah, EA | 2 |
| Elgohary, MM | 2 |
| Ragab, DM | 1 |
| Mortada, SM | 2 |
| Yao, Z | 1 |
| Wan, Y | 1 |
| Li, B | 1 |
| Zhai, C | 1 |
| Yao, F | 1 |
| Kang, Y | 1 |
| Liu, Q | 1 |
| Lin, D | 1 |
| Song, J | 1 |
| Lin, C | 1 |
| Xie, Y | 2 |
| Hu, P | 1 |
| Fu, L | 2 |
| Chen, W | 1 |
| Guo, W | 1 |
| Wang, J | 2 |
| Tian, Y | 1 |
| Shi, D | 2 |
| Qiu, H | 1 |
| Xiao, X | 2 |
| Kang, T | 1 |
| Huang, W | 2 |
| Wang, S | 1 |
| Deng, W | 2 |
| Qi, HW | 1 |
| Xin, LY | 1 |
| Xu, X | 1 |
| Ji, XX | 1 |
| Fan, LH | 1 |
| Godugu, C | 1 |
| Patel, AR | 1 |
| Doddapaneni, R | 1 |
| Somagoni, J | 1 |
| Singh, M | 1 |
| Zhao, S | 1 |
| Liang, Z | 1 |
| Li, L | 2 |
| Wu, W | 1 |
| Hann, S | 1 |
| Xi, S | 1 |
| Chuang, K | 1 |
| Fang, K | 1 |
| Lee, Y | 1 |
| Chung, J | 1 |
| Chuang, Y | 1 |
| Tsang, CM | 1 |
| Cheung, KC | 1 |
| Cheung, YC | 1 |
| Man, K | 1 |
| Lui, VW | 1 |
| Tsao, SW | 1 |
| Feng, Y | 1 |
| Yang, J | 1 |
| Zheng, M | 1 |
| Kong, X | 1 |
| Cai, YD | 1 |
| Jiang, G | 1 |
| Wu, X | 1 |
| Dong, S | 1 |
| Tong, X | 1 |
| Yuan, ZW | 1 |
| Leung, EL | 1 |
| Fan, XX | 1 |
| Zhou, H | 1 |
| Ma, WZ | 1 |
| Liu, L | 1 |
| Zhu, T | 1 |
| Li, LL | 1 |
| Xiao, GF | 1 |
| Luo, QZ | 1 |
| Liu, QZ | 1 |
| Yao, KT | 1 |
| Xiao, GH | 1 |
| Tang, Z | 1 |
| Zhang, C | 2 |
| Qin, L | 1 |
| Yu, Z | 1 |
| Xie, F | 1 |
| Liu, Y | 2 |
| Yu, H | 1 |
| Cheng, Y | 1 |
| Hu, L | 1 |
| Meng, X | 1 |
| James, MA | 1 |
| Fu, H | 1 |
| Chen, DR | 1 |
| You, M | 1 |
| Hamsa, TP | 1 |
| Kuttan, G | 1 |
| Peng, PL | 2 |
| Hsieh, YS | 1 |
| Wang, CJ | 1 |
| Hsu, JL | 1 |
| Chou, FP | 2 |
| Kuo, WH | 1 |
| Tseng, HC | 1 |
| Hao, Y | 2 |
| Wang, P | 1 |
| Qiu, QY | 1 |
| Luo, Y | 1 |
| Shi, TP | 1 |
| Deng, WW | 1 |
| Li, N | 1 |
| Katiyar, SK | 1 |
| Meeran, SM | 1 |
| Katiyar, N | 1 |
| Akhtar, S | 1 |
| Mitani, N | 1 |
| Murakami, K | 1 |
| Yamaura, T | 1 |
| Ikeda, T | 1 |
| Saiki, I | 1 |
| Iwasa, K | 1 |
| Moriyasu, M | 1 |
| Yamori, T | 1 |
| Turuo, T | 1 |
| Lee, DU | 1 |
| Wiegrebe, W | 1 |
1 review available for berberine and Lung Neoplasms
| Article | Year |
|---|---|
Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment.
Topics: Antineoplastic Agents; Apoptosis; Berberine; Cell Proliferation; Humans; Lung Neoplasms; Tumor Micro | 2022 |
1 trial available for berberine and Lung Neoplasms
| Article | Year |
|---|---|
Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer.
Topics: Aged; Berberine; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Double-Blind Method; Fem | 2008 |
49 other studies available for berberine and Lung Neoplasms
| Article | Year |
|---|---|
Synergistic inhibitory effect of berberine and icotinib on non-small cell lung cancer cells via inducing autophagic cell death and apoptosis.
Topics: Animals; Apoptosis; Autophagic Cell Death; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2021 |
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition.
Topics: Acrylamides; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Berberine; Biological Pro | 2022 |
Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro.
Topics: Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neopla | 2022 |
Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer.
Topics: Animals; bcl-2-Associated X Protein; Berberine; Caspase 9; Chitosan; Lung Neoplasms; Male; Mice; Nan | 2022 |
Berberine regulates PADI4-related macrophage function to prevent lung cancer.
Topics: Animals; Apoptosis; Berberine; Epithelial-Mesenchymal Transition; Interferon Regulatory Factors; Lun | 2022 |
Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation.
Topics: Animals; Berberine; Breast Neoplasms; Caveolin 1; Cholesterol; Extracellular Traps; Female; Histones | 2022 |
Berberine targets KIF20A and CCNE2 to inhibit the progression of nonsmall cell lung cancer via the PI3K/AKT pathway.
Topics: Animals; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell | 2023 |
Antitumor effects of erlotinib in combination with berberine in A431 cells.
Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Erb | 2023 |
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Berberine; beta Catenin; Catenins; Cell Line, Tumor; Cell Movement; Cell Pro | 2023 |
CD44 tagged hyaluronic acid - chitosan liposome carrier for the delivery of berberine and doxorubicin into lung cancer cells.
Topics: Animals; Berberine; Caenorhabditis elegans; Chitosan; Doxorubicin; Drug Delivery Systems; Humans; Hy | 2023 |
Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining Network Pharmacology, Molecular Docking, and Experimental Verification.
Topics: Autophagy; Berberine; Carcinoma, Non-Small-Cell Lung; Humans; I-kappa B Kinase; Lung Neoplasms; Mole | 2023 |
Berberine induces dose-dependent quiescence and apoptosis in A549 cancer cells by modulating cell cyclins and inflammation independent of mTOR pathway.
Topics: A549 Cells; Apoptosis; Berberine; Cell Proliferation; Cellular Senescence; Cyclins; Gene Expression | 2020 |
Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer.
Topics: Animals; Apoptosis; Berberine; Cell Line, Tumor; Cell Movement; Cell Survival; Epithelial-Mesenchyma | 2020 |
Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells.
Topics: A549 Cells; Antineoplastic Agents; Berberine; Bromides; Carcinoma, Non-Small-Cell Lung; Cell Cycle; | 2020 |
Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Carcinoma, Non-Small-C | 2020 |
Natural alkaloid 8-oxo-epiberberine inhibited TGF-β1-triggred epithelial-mesenchymal transition by interfering Smad3.
Topics: Animals; Antineoplastic Agents; Berberine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Epithelia | 2020 |
Biomimetic co-assembled nanodrug of doxorubicin and berberine suppresses chemotherapy-exacerbated breast cancer metastasis.
Topics: Animals; Berberine; Biomimetics; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Humans; Lung Neopl | 2021 |
Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway.
Topics: Animals; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cellul | 2021 |
Berberine inhibits non-small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2022 |
Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators.
Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Berberin | 2017 |
Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1.
Topics: Berberine; Cell Survival; Dose-Response Relationship, Drug; Humans; Immunotherapy; Indoleamine-Pyrro | 2018 |
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Berberine; Biomarkers, Tumor; Bod | 2018 |
Berberine Suppresses Cell Motility Through Downregulation of TGF-β1 in Triple Negative Breast Cancer Cells.
Topics: Animals; Benzamides; Berberine; Cell Line, Tumor; Cell Movement; Databases, Factual; Dioxoles; Down- | 2018 |
Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma.
Topics: A549 Cells; Animals; Antineoplastic Agents; Berberine; Cell Proliferation; Drug Carriers; Drug Deliv | 2018 |
Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor/herbal combined therapy of lung carcinoma.
Topics: A549 Cells; Adenocarcinoma; Administration, Inhalation; Animals; Antineoplastic Combined Chemotherap | 2018 |
Targeting sialic acid residues on lung cancer cells by inhalable boronic acid-decorated albumin nanocomposites for combined chemo/herbal therapy.
Topics: A549 Cells; Administration, Inhalation; Animals; Antineoplastic Agents, Phytogenic; Berberine; Boron | 2018 |
Dual-targeted nano-in-nano albumin carriers enhance the efficacy of combined chemo/herbal therapy of lung cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Berberine; Cell Survival; Drug Carriers; Drug | 2018 |
Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells.
Topics: Antineoplastic Agents; Autophagy; Berberine; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell S | 2018 |
Mitochondrial targeting nanodrugs self-assembled from 9-O-octadecyl substituted berberine derivative for cancer treatment by inducing mitochondrial apoptosis pathways.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Berberine; Cytochromes c; Drug Delivery Syste | 2019 |
Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth.
Topics: Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tu | 2013 |
Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis.
Topics: Animals; Apoptosis; Berberine; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2014 |
Approaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Berberine; Betulinic Acid; Biological Availabi | 2014 |
p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Berberine; Cell Line, Tumo | 2014 |
Effect of berberine on activity and mRNA expression of N-acetyltransferase in human lung cancer cell line A549.
Topics: Berberine; Cell Line, Tumor; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Humans; | 2014 |
Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma.
Topics: Animals; Berberine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression | 2015 |
The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
Topics: Animals; Antineoplastic Agents; Arsenicals; Berberine; Carcinogenesis; Carcinoma, Non-Small-Cell Lun | 2015 |
[Influence of Berberine on Cisplatin Antineoplastic Effect in A549 Cells].
Topics: Antineoplastic Agents; Apoptosis; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2015 |
Quantitative evaluation of berberine subcellular distribution and cellular accumulation in non-small cell lung cancer cells by UPLC-MS/MS.
Topics: Antineoplastic Agents; Berberine; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Line, T | 2015 |
Berberine Increases Doxorubicin Sensitivity by Suppressing STAT3 in Lung Cancer.
Topics: Apoptosis; Berberine; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Coptis | 2015 |
Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells.
Topics: Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 2016 |
Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis.
Topics: Animals; Berberine; Blotting, Western; Cell Cycle; Cell Proliferation; Diet; Disease Progression; Hu | 2011 |
Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells.
Topics: Activating Transcription Factor 2; Animals; Antineoplastic Agents, Phytogenic; Berberine; Cell Line, | 2012 |
Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2006 |
Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death.
Topics: Acridine Orange; Animals; Autophagy; Berberine; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lun | 2008 |
[Effects of ginsenoside and berberine on secretion of immunosuppressive cytokines in lung carcinoma cell line PG].
Topics: Apoptosis; Berberine; Coculture Techniques; Dinoprostone; Ginsenosides; Humans; Jurkat Cells; Lung N | 2008 |
Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif.
Topics: Amino Acid Motifs; Antineoplastic Agents; Berberine; Carcinoma, Giant Cell; Cell Line, Tumor; Cell P | 2008 |
p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo.
Topics: Animals; Apoptosis; Berberine; Blotting, Western; Bronchi; Carcinoma, Non-Small-Cell Lung; Caspase 3 | 2009 |
Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Berberine; Camptothecin; Carcinoma, Lewis L | 2001 |
In vitro cytotoxicity of the protoberberine-type alkaloids.
Topics: Animals; Antineoplastic Agents, Phytogenic; Berberine; Berberine Alkaloids; Brain Neoplasms; Breast | 2001 |