berberine has been researched along with Liver Cirrhosis in 11 studies
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These may include liver fibrosis, liver cirrhosis, and drug-induced liver toxicity." | 2.72 | Molecular updates on berberine in liver diseases: Bench to bedside. ( Bansod, S; Godugu, C; Saifi, MA, 2021) |
| "Berberine (BBR) is an effective drug against liver fibrosis (LF)." | 1.91 | Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis. ( Deng, F; Li, C; Liu, Y; Tan, Y; Zhou, J, 2023) |
| "Berberine (BBR) is an isoquinoline alkaloid extracted from the roots, rhizomes and stems of coptis." | 1.48 | Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats. ( Eissa, LA; El-Karef, A; El-Mihi, KA; Elsherbiny, NM; Kenawy, HI, 2018) |
| "The histological spectrum of nonalcoholic fatty liver diseases (NAFLD) ranges from hepatic steatosis to steatohepatitis and fibrosis." | 1.43 | Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress. ( Cai, D; Jin, L; Li, B; Meng, X; Ning, G; Wang, J; Yang, J; Yao, S; Zhang, H; Zhang, Y; Zhang, Z, 2016) |
| "Demethyleneberberine (DMB) is an essential metabolite of Berberine (BBR) in vivo." | 1.43 | Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-κB Signaling. ( Chen, H; Li, R; Qiang, X; Wang, Y; Yan, Y; Zhang, Y; Zhao, Z; Zhou, C, 2016) |
| "CCl4-induced chronic liver fibrosis model in mice was established and activated rat hepatic stellate cell was treated with BBR." | 1.40 | Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase. ( Chen, L; Guan, F; Kan, M; Li, J; Pan, Y; Wang, Y; Xiao, X; Zhang, X, 2014) |
| "Liver fibrosis is the result of chronic liver injury, and it represents a widespread medical problem." | 1.39 | Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression. ( Blažeković, B; Domitrović, R; Jakovac, H; Marchesi, VV, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| He, H | 1 |
| Chai, X | 1 |
| Li, J | 2 |
| Li, C | 2 |
| Wu, X | 1 |
| Ye, X | 1 |
| Ma, H | 1 |
| Li, X | 1 |
| Tan, Y | 1 |
| Zhou, J | 1 |
| Deng, F | 1 |
| Liu, Y | 1 |
| Bansod, S | 1 |
| Saifi, MA | 1 |
| Godugu, C | 1 |
| Eissa, LA | 1 |
| Kenawy, HI | 1 |
| El-Karef, A | 1 |
| Elsherbiny, NM | 1 |
| El-Mihi, KA | 1 |
| Domitrović, R | 1 |
| Jakovac, H | 1 |
| Marchesi, VV | 1 |
| Blažeković, B | 1 |
| Pan, Y | 1 |
| Kan, M | 1 |
| Xiao, X | 1 |
| Wang, Y | 2 |
| Guan, F | 1 |
| Zhang, X | 1 |
| Chen, L | 1 |
| Zhang, Z | 2 |
| Li, B | 1 |
| Meng, X | 1 |
| Yao, S | 1 |
| Jin, L | 1 |
| Yang, J | 1 |
| Wang, J | 1 |
| Zhang, H | 1 |
| Cai, D | 1 |
| Zhang, Y | 2 |
| Ning, G | 1 |
| Zhao, Z | 1 |
| Yan, Y | 1 |
| Qiang, X | 1 |
| Zhou, C | 1 |
| Li, R | 1 |
| Chen, H | 1 |
| Zhang, BJ | 1 |
| Xu, D | 1 |
| Guo, Y | 1 |
| Ping, J | 1 |
| Chen, LB | 1 |
| Wang, H | 1 |
| Zhao, W | 1 |
| Xue, R | 1 |
| Zhou, ZX | 1 |
| Kong, WJ | 1 |
| Jiang, JD | 1 |
| Watanabe, A | 1 |
| Obata, T | 1 |
| Nagashima, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled Trial[NCT03198572] | Phase 4 | 120 participants (Anticipated) | Interventional | 2017-08-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for berberine and Liver Cirrhosis
| Article | Year |
|---|---|
Molecular updates on berberine in liver diseases: Bench to bedside.
Topics: Berberine; Humans; Insulin; Liver Cirrhosis; PPAR gamma; Signal Transduction | 2021 |
10 other studies available for berberine and Liver Cirrhosis
| Article | Year |
|---|---|
LCN2 contributes to the improvement of nonalcoholic steatohepatitis by 8-Cetylberberine.
Topics: Animals; Berberine; Diet, High-Fat; Disease Models, Animal; Inflammation; Lipids; Lipocalin-2; Liver | 2023 |
Berberine attenuates liver fibrosis by autophagy inhibition triggering apoptosis via the miR-30a-5p/ATG5 axis.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Berberine; Collagen; Hepatic Stellate Cells; Liver | 2023 |
Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats.
Topics: Actins; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Berberine; Collagen; Cytokines; | 2018 |
Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression.
Topics: Animals; Berberine; Carbon Tetrachloride; Hepatic Stellate Cells; Humans; Isoquinolines; Liver Cirrh | 2013 |
Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Blotting, Western; Body Weight; Cell Proliferatio | 2014 |
Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.
Topics: Activating Transcription Factor 6; Animals; Berberine; Cell Line; Endoplasmic Reticulum Stress; Hepa | 2016 |
Demethyleneberberine Protects against Hepatic Fibrosis in Mice by Modulating NF-κB Signaling.
Topics: Actins; Animals; Apoptosis; Berberine; Cell Line; Collagen; Disease Models, Animal; Hepatic Stellate | 2016 |
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Berberine; Carbon Tetrachloride; | 2008 |
Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis.
Topics: Adult; Berberine; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Hyperlipidemias; Hypol | 2008 |
Berberine therapy of hypertyraminemia in patients with liver cirrhosis.
Topics: Berberine; Berberine Alkaloids; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle Aged; | 1982 |